Molecular mediators of breast cancer metastasis

Breast cancer has the highest incidence rate of malignancy in women worldwide. A major clinical challenge faced by patients with breast cancer treated by conventional therapies is frequent relapse. This relapse has been attributed to the cancer stem cell (CSC) population that resides within the tumo...

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Autores principales:	Ragini Yeeravalli, Amitava Das
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Breast cancer stem cells Epithelial-mesenchymal transition Metastasis Molecular mediators Relapse Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/9a9ab181f68241d79f6050be0addf87e
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spelling	oai:doaj.org-article:9a9ab181f68241d79f6050be0addf87e2021-12-02T05:00:03ZMolecular mediators of breast cancer metastasis1658-387610.1016/j.hemonc.2021.02.002https://doaj.org/article/9a9ab181f68241d79f6050be0addf87e2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1658387621000273https://doaj.org/toc/1658-3876Breast cancer has the highest incidence rate of malignancy in women worldwide. A major clinical challenge faced by patients with breast cancer treated by conventional therapies is frequent relapse. This relapse has been attributed to the cancer stem cell (CSC) population that resides within the tumor and possess stemness properties. Breast CSCs are generated when breast cancer cells undergo epithelial-mesenchymal transition resulting in aggressive, highly metastatic, and invasive phenotypes that exhibit resistance towards chemotherapeutics. Metastasis, a phenomenon that aids in the migration of breast CSCs, occurs through any of three different routes: hematogenous, lymphatic, and transcoelomic. Hematogenous dissemination of breast CSCs leads to metastasis towards distant unrelated organs like lungs, liver, bone, and brain causing secondary tumor generation. Activation of metastasis genes or silencing of metastasis suppressor genes often leads to the advancement of metastasis. This review focuses on various genes and molecular factors that have been implicated to regulate organ-specific breast cancer metastasis by defying the available therapeutic interventions.Ragini YeeravalliAmitava DasElsevierarticleBreast cancer stem cellsEpithelial-mesenchymal transitionMetastasisMolecular mediatorsRelapseDiseases of the blood and blood-forming organsRC633-647.5Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENHematology/Oncology and Stem Cell Therapy, Vol 14, Iss 4, Pp 275-289 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Breast cancer stem cells Epithelial-mesenchymal transition Metastasis Molecular mediators Relapse Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Breast cancer stem cells Epithelial-mesenchymal transition Metastasis Molecular mediators Relapse Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ragini Yeeravalli Amitava Das Molecular mediators of breast cancer metastasis
description	Breast cancer has the highest incidence rate of malignancy in women worldwide. A major clinical challenge faced by patients with breast cancer treated by conventional therapies is frequent relapse. This relapse has been attributed to the cancer stem cell (CSC) population that resides within the tumor and possess stemness properties. Breast CSCs are generated when breast cancer cells undergo epithelial-mesenchymal transition resulting in aggressive, highly metastatic, and invasive phenotypes that exhibit resistance towards chemotherapeutics. Metastasis, a phenomenon that aids in the migration of breast CSCs, occurs through any of three different routes: hematogenous, lymphatic, and transcoelomic. Hematogenous dissemination of breast CSCs leads to metastasis towards distant unrelated organs like lungs, liver, bone, and brain causing secondary tumor generation. Activation of metastasis genes or silencing of metastasis suppressor genes often leads to the advancement of metastasis. This review focuses on various genes and molecular factors that have been implicated to regulate organ-specific breast cancer metastasis by defying the available therapeutic interventions.
format	article
author	Ragini Yeeravalli Amitava Das
author_facet	Ragini Yeeravalli Amitava Das
author_sort	Ragini Yeeravalli
title	Molecular mediators of breast cancer metastasis
title_short	Molecular mediators of breast cancer metastasis
title_full	Molecular mediators of breast cancer metastasis
title_fullStr	Molecular mediators of breast cancer metastasis
title_full_unstemmed	Molecular mediators of breast cancer metastasis
title_sort	molecular mediators of breast cancer metastasis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/9a9ab181f68241d79f6050be0addf87e
work_keys_str_mv	AT raginiyeeravalli molecularmediatorsofbreastcancermetastasis AT amitavadas molecularmediatorsofbreastcancermetastasis
_version_	1718400905231990784

Molecular mediators of breast cancer metastasis

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