TRPV4 Mechanotransduction in Fibrosis

Fibrosis is an irreversible, debilitating condition marked by the excessive production of extracellular matrix and tissue scarring that eventually results in organ failure and disease. Differentiation of fibroblasts to hypersecretory myofibroblasts is the key event in fibrosis. Although both soluble...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ravi K. Adapala, Venkatesh Katari, Lakshminarayan Reddy Teegala, Sathwika Thodeti, Sailaja Paruchuri, Charles K. Thodeti
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	calcium extracellular matrix fibroblast fibrosis mechanotransduction myofibroblast Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9a9e435468a54c488590fc3d94a0e42b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9a9e435468a54c488590fc3d94a0e42b
record_format	dspace
spelling	oai:doaj.org-article:9a9e435468a54c488590fc3d94a0e42b2021-11-25T17:10:57ZTRPV4 Mechanotransduction in Fibrosis10.3390/cells101130532073-4409https://doaj.org/article/9a9e435468a54c488590fc3d94a0e42b2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3053https://doaj.org/toc/2073-4409Fibrosis is an irreversible, debilitating condition marked by the excessive production of extracellular matrix and tissue scarring that eventually results in organ failure and disease. Differentiation of fibroblasts to hypersecretory myofibroblasts is the key event in fibrosis. Although both soluble and mechanical factors are implicated in fibroblast differentiation, much of the focus is on TGF-β signaling, but to date, there are no specific drugs available for the treatment of fibrosis. In this review, we describe the role for TRPV4 mechanotransduction in cardiac and lung fibrosis, and we propose TRPV4 as an alternative therapeutic target for fibrosis.Ravi K. AdapalaVenkatesh KatariLakshminarayan Reddy TeegalaSathwika ThodetiSailaja ParuchuriCharles K. ThodetiMDPI AGarticlecalciumextracellular matrixfibroblastfibrosismechanotransductionmyofibroblastBiology (General)QH301-705.5ENCells, Vol 10, Iss 3053, p 3053 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	calcium extracellular matrix fibroblast fibrosis mechanotransduction myofibroblast Biology (General) QH301-705.5
spellingShingle	calcium extracellular matrix fibroblast fibrosis mechanotransduction myofibroblast Biology (General) QH301-705.5 Ravi K. Adapala Venkatesh Katari Lakshminarayan Reddy Teegala Sathwika Thodeti Sailaja Paruchuri Charles K. Thodeti TRPV4 Mechanotransduction in Fibrosis
description	Fibrosis is an irreversible, debilitating condition marked by the excessive production of extracellular matrix and tissue scarring that eventually results in organ failure and disease. Differentiation of fibroblasts to hypersecretory myofibroblasts is the key event in fibrosis. Although both soluble and mechanical factors are implicated in fibroblast differentiation, much of the focus is on TGF-β signaling, but to date, there are no specific drugs available for the treatment of fibrosis. In this review, we describe the role for TRPV4 mechanotransduction in cardiac and lung fibrosis, and we propose TRPV4 as an alternative therapeutic target for fibrosis.
format	article
author	Ravi K. Adapala Venkatesh Katari Lakshminarayan Reddy Teegala Sathwika Thodeti Sailaja Paruchuri Charles K. Thodeti
author_facet	Ravi K. Adapala Venkatesh Katari Lakshminarayan Reddy Teegala Sathwika Thodeti Sailaja Paruchuri Charles K. Thodeti
author_sort	Ravi K. Adapala
title	TRPV4 Mechanotransduction in Fibrosis
title_short	TRPV4 Mechanotransduction in Fibrosis
title_full	TRPV4 Mechanotransduction in Fibrosis
title_fullStr	TRPV4 Mechanotransduction in Fibrosis
title_full_unstemmed	TRPV4 Mechanotransduction in Fibrosis
title_sort	trpv4 mechanotransduction in fibrosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9a9e435468a54c488590fc3d94a0e42b
work_keys_str_mv	AT ravikadapala trpv4mechanotransductioninfibrosis AT venkateshkatari trpv4mechanotransductioninfibrosis AT lakshminarayanreddyteegala trpv4mechanotransductioninfibrosis AT sathwikathodeti trpv4mechanotransductioninfibrosis AT sailajaparuchuri trpv4mechanotransductioninfibrosis AT charleskthodeti trpv4mechanotransductioninfibrosis
_version_	1718412668032778240

TRPV4 Mechanotransduction in Fibrosis

Ejemplares similares