RPA shields inherited DNA lesions for post-mitotic DNA synthesis

Single-stranded DNA during DNA replication and repair in S/G2 needs protection by replication protein A (RPA). Here the authors reveal that RPA also shields inherited single-stranded DNA in G1, representing replication remnants from the previous cell cycle, to allow for post-mitotic DNA synthesis.

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Autores principales:	Aleksandra Lezaja, Andreas Panagopoulos, Yanlin Wen, Edison Carvalho, Ralph Imhof, Matthias Altmeyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9a9e8cf86c824c509c51e25d4696fdaf
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spelling	oai:doaj.org-article:9a9e8cf86c824c509c51e25d4696fdaf2021-12-02T17:12:20ZRPA shields inherited DNA lesions for post-mitotic DNA synthesis10.1038/s41467-021-23806-52041-1723https://doaj.org/article/9a9e8cf86c824c509c51e25d4696fdaf2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23806-5https://doaj.org/toc/2041-1723Single-stranded DNA during DNA replication and repair in S/G2 needs protection by replication protein A (RPA). Here the authors reveal that RPA also shields inherited single-stranded DNA in G1, representing replication remnants from the previous cell cycle, to allow for post-mitotic DNA synthesis.Aleksandra LezajaAndreas PanagopoulosYanlin WenEdison CarvalhoRalph ImhofMatthias AltmeyerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aleksandra Lezaja Andreas Panagopoulos Yanlin Wen Edison Carvalho Ralph Imhof Matthias Altmeyer RPA shields inherited DNA lesions for post-mitotic DNA synthesis
description	Single-stranded DNA during DNA replication and repair in S/G2 needs protection by replication protein A (RPA). Here the authors reveal that RPA also shields inherited single-stranded DNA in G1, representing replication remnants from the previous cell cycle, to allow for post-mitotic DNA synthesis.
format	article
author	Aleksandra Lezaja Andreas Panagopoulos Yanlin Wen Edison Carvalho Ralph Imhof Matthias Altmeyer
author_facet	Aleksandra Lezaja Andreas Panagopoulos Yanlin Wen Edison Carvalho Ralph Imhof Matthias Altmeyer
author_sort	Aleksandra Lezaja
title	RPA shields inherited DNA lesions for post-mitotic DNA synthesis
title_short	RPA shields inherited DNA lesions for post-mitotic DNA synthesis
title_full	RPA shields inherited DNA lesions for post-mitotic DNA synthesis
title_fullStr	RPA shields inherited DNA lesions for post-mitotic DNA synthesis
title_full_unstemmed	RPA shields inherited DNA lesions for post-mitotic DNA synthesis
title_sort	rpa shields inherited dna lesions for post-mitotic dna synthesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9a9e8cf86c824c509c51e25d4696fdaf
work_keys_str_mv	AT aleksandralezaja rpashieldsinheriteddnalesionsforpostmitoticdnasynthesis AT andreaspanagopoulos rpashieldsinheriteddnalesionsforpostmitoticdnasynthesis AT yanlinwen rpashieldsinheriteddnalesionsforpostmitoticdnasynthesis AT edisoncarvalho rpashieldsinheriteddnalesionsforpostmitoticdnasynthesis AT ralphimhof rpashieldsinheriteddnalesionsforpostmitoticdnasynthesis AT matthiasaltmeyer rpashieldsinheriteddnalesionsforpostmitoticdnasynthesis
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RPA shields inherited DNA lesions for post-mitotic DNA synthesis

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