The Mammalian Locus Coeruleus Complex—Consistencies and Variances in Nuclear Organization

Descriptions of the nuclear parcellation of the locus coeruleus complex have been provided in approximately 80 mammal species spanning the phylogenetic breadth of this class. Within the mammalian rostral hindbrain, noradrenergic neurons (revealed with tyrosine hydroxylase and dopamine-ß-hydroxylase...

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Autores principales: Paul R. Manger, Oxana Eschenko
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Publicado: MDPI AG 2021
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spelling oai:doaj.org-article:9a9eac9c9bf94a56a765f676a0af2b5d2021-11-25T16:58:18ZThe Mammalian Locus Coeruleus Complex—Consistencies and Variances in Nuclear Organization10.3390/brainsci111114862076-3425https://doaj.org/article/9a9eac9c9bf94a56a765f676a0af2b5d2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1486https://doaj.org/toc/2076-3425Descriptions of the nuclear parcellation of the locus coeruleus complex have been provided in approximately 80 mammal species spanning the phylogenetic breadth of this class. Within the mammalian rostral hindbrain, noradrenergic neurons (revealed with tyrosine hydroxylase and dopamine-ß-hydroxylase immunohistochemistry) have been observed within the periventricular grey matter (A4 and A6 nuclei) and parvicellular reticular nucleus (A5 and A7 nuclei), with the one exception to date being the tree pangolin, where no A4/A6 neurons are observed. The alphanumeric nomenclature system, developed in laboratory rodent brains, has been adapted to cover the variation observed across species. Cross-species homology is observed regarding the nuclear organization of noradrenergic neurons located in the parvicellular reticular nucleus (A5 and A7). In contrast, significant variations are observed in the organization of the A6 neurons of the locus coeruleus proper. In most mammals, the A6 is comprised of a moderate density of neurons, but in Murid rodents, primates, and megachiropteran bats, the A6 exhibits a very high density of neurons. In primates and megachiropterans, there is an additional moderate density of A6 neurons located rostromedial to the high-density portion. These variations are of importance in understanding the translation of findings in laboratory rodents to humans.Paul R. MangerOxana EschenkoMDPI AGarticlenoradrenalinecatecholaminesevolutionmammalian brainsubcoeruleuslocus coeruleusNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1486, p 1486 (2021)
institution DOAJ
collection DOAJ
language EN
topic noradrenaline
catecholamines
evolution
mammalian brain
subcoeruleus
locus coeruleus
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
spellingShingle noradrenaline
catecholamines
evolution
mammalian brain
subcoeruleus
locus coeruleus
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Paul R. Manger
Oxana Eschenko
The Mammalian Locus Coeruleus Complex—Consistencies and Variances in Nuclear Organization
description Descriptions of the nuclear parcellation of the locus coeruleus complex have been provided in approximately 80 mammal species spanning the phylogenetic breadth of this class. Within the mammalian rostral hindbrain, noradrenergic neurons (revealed with tyrosine hydroxylase and dopamine-ß-hydroxylase immunohistochemistry) have been observed within the periventricular grey matter (A4 and A6 nuclei) and parvicellular reticular nucleus (A5 and A7 nuclei), with the one exception to date being the tree pangolin, where no A4/A6 neurons are observed. The alphanumeric nomenclature system, developed in laboratory rodent brains, has been adapted to cover the variation observed across species. Cross-species homology is observed regarding the nuclear organization of noradrenergic neurons located in the parvicellular reticular nucleus (A5 and A7). In contrast, significant variations are observed in the organization of the A6 neurons of the locus coeruleus proper. In most mammals, the A6 is comprised of a moderate density of neurons, but in Murid rodents, primates, and megachiropteran bats, the A6 exhibits a very high density of neurons. In primates and megachiropterans, there is an additional moderate density of A6 neurons located rostromedial to the high-density portion. These variations are of importance in understanding the translation of findings in laboratory rodents to humans.
format article
author Paul R. Manger
Oxana Eschenko
author_facet Paul R. Manger
Oxana Eschenko
author_sort Paul R. Manger
title The Mammalian Locus Coeruleus Complex—Consistencies and Variances in Nuclear Organization
title_short The Mammalian Locus Coeruleus Complex—Consistencies and Variances in Nuclear Organization
title_full The Mammalian Locus Coeruleus Complex—Consistencies and Variances in Nuclear Organization
title_fullStr The Mammalian Locus Coeruleus Complex—Consistencies and Variances in Nuclear Organization
title_full_unstemmed The Mammalian Locus Coeruleus Complex—Consistencies and Variances in Nuclear Organization
title_sort mammalian locus coeruleus complex—consistencies and variances in nuclear organization
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/9a9eac9c9bf94a56a765f676a0af2b5d
work_keys_str_mv AT paulrmanger themammalianlocuscoeruleuscomplexconsistenciesandvariancesinnuclearorganization
AT oxanaeschenko themammalianlocuscoeruleuscomplexconsistenciesandvariancesinnuclearorganization
AT paulrmanger mammalianlocuscoeruleuscomplexconsistenciesandvariancesinnuclearorganization
AT oxanaeschenko mammalianlocuscoeruleuscomplexconsistenciesandvariancesinnuclearorganization
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