The Mammalian Locus Coeruleus Complex—Consistencies and Variances in Nuclear Organization

Descriptions of the nuclear parcellation of the locus coeruleus complex have been provided in approximately 80 mammal species spanning the phylogenetic breadth of this class. Within the mammalian rostral hindbrain, noradrenergic neurons (revealed with tyrosine hydroxylase and dopamine-ß-hydroxylase...

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Autores principales:	Paul R. Manger, Oxana Eschenko
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	noradrenaline catecholamines evolution mammalian brain subcoeruleus locus coeruleus Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/9a9eac9c9bf94a56a765f676a0af2b5d
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spelling	oai:doaj.org-article:9a9eac9c9bf94a56a765f676a0af2b5d2021-11-25T16:58:18ZThe Mammalian Locus Coeruleus Complex—Consistencies and Variances in Nuclear Organization10.3390/brainsci111114862076-3425https://doaj.org/article/9a9eac9c9bf94a56a765f676a0af2b5d2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1486https://doaj.org/toc/2076-3425Descriptions of the nuclear parcellation of the locus coeruleus complex have been provided in approximately 80 mammal species spanning the phylogenetic breadth of this class. Within the mammalian rostral hindbrain, noradrenergic neurons (revealed with tyrosine hydroxylase and dopamine-ß-hydroxylase immunohistochemistry) have been observed within the periventricular grey matter (A4 and A6 nuclei) and parvicellular reticular nucleus (A5 and A7 nuclei), with the one exception to date being the tree pangolin, where no A4/A6 neurons are observed. The alphanumeric nomenclature system, developed in laboratory rodent brains, has been adapted to cover the variation observed across species. Cross-species homology is observed regarding the nuclear organization of noradrenergic neurons located in the parvicellular reticular nucleus (A5 and A7). In contrast, significant variations are observed in the organization of the A6 neurons of the locus coeruleus proper. In most mammals, the A6 is comprised of a moderate density of neurons, but in Murid rodents, primates, and megachiropteran bats, the A6 exhibits a very high density of neurons. In primates and megachiropterans, there is an additional moderate density of A6 neurons located rostromedial to the high-density portion. These variations are of importance in understanding the translation of findings in laboratory rodents to humans.Paul R. MangerOxana EschenkoMDPI AGarticlenoradrenalinecatecholaminesevolutionmammalian brainsubcoeruleuslocus coeruleusNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1486, p 1486 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	noradrenaline catecholamines evolution mammalian brain subcoeruleus locus coeruleus Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	noradrenaline catecholamines evolution mammalian brain subcoeruleus locus coeruleus Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Paul R. Manger Oxana Eschenko The Mammalian Locus Coeruleus Complex—Consistencies and Variances in Nuclear Organization
description	Descriptions of the nuclear parcellation of the locus coeruleus complex have been provided in approximately 80 mammal species spanning the phylogenetic breadth of this class. Within the mammalian rostral hindbrain, noradrenergic neurons (revealed with tyrosine hydroxylase and dopamine-ß-hydroxylase immunohistochemistry) have been observed within the periventricular grey matter (A4 and A6 nuclei) and parvicellular reticular nucleus (A5 and A7 nuclei), with the one exception to date being the tree pangolin, where no A4/A6 neurons are observed. The alphanumeric nomenclature system, developed in laboratory rodent brains, has been adapted to cover the variation observed across species. Cross-species homology is observed regarding the nuclear organization of noradrenergic neurons located in the parvicellular reticular nucleus (A5 and A7). In contrast, significant variations are observed in the organization of the A6 neurons of the locus coeruleus proper. In most mammals, the A6 is comprised of a moderate density of neurons, but in Murid rodents, primates, and megachiropteran bats, the A6 exhibits a very high density of neurons. In primates and megachiropterans, there is an additional moderate density of A6 neurons located rostromedial to the high-density portion. These variations are of importance in understanding the translation of findings in laboratory rodents to humans.
format	article
author	Paul R. Manger Oxana Eschenko
author_facet	Paul R. Manger Oxana Eschenko
author_sort	Paul R. Manger
title	The Mammalian Locus Coeruleus Complex—Consistencies and Variances in Nuclear Organization
title_short	The Mammalian Locus Coeruleus Complex—Consistencies and Variances in Nuclear Organization
title_full	The Mammalian Locus Coeruleus Complex—Consistencies and Variances in Nuclear Organization
title_fullStr	The Mammalian Locus Coeruleus Complex—Consistencies and Variances in Nuclear Organization
title_full_unstemmed	The Mammalian Locus Coeruleus Complex—Consistencies and Variances in Nuclear Organization
title_sort	mammalian locus coeruleus complex—consistencies and variances in nuclear organization
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9a9eac9c9bf94a56a765f676a0af2b5d
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The Mammalian Locus Coeruleus Complex—Consistencies and Variances in Nuclear Organization

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