Psoas muscle area and paraspinal muscle fat in children and young adults with or without obesity and fatty liver

<h4>Background</h4> Little is known about the muscle condition in children with obesity. <h4>Objectives</h4> To investigate the effect of obesity and fatty liver on muscle area and muscle fat in children and young adults. <h4>Materials and methods</h4> We evaluate...

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Autores principales:	Salman S. Albakheet, Mi-Jung Lee, Haesung Yoon, Hyun Joo Shin, Hong Koh
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9aa1df6a81ce4575afe2f20933031a7f
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spelling	oai:doaj.org-article:9aa1df6a81ce4575afe2f20933031a7f2021-11-25T06:19:47ZPsoas muscle area and paraspinal muscle fat in children and young adults with or without obesity and fatty liver1932-6203https://doaj.org/article/9aa1df6a81ce4575afe2f20933031a7f2021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598034/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4> Little is known about the muscle condition in children with obesity. <h4>Objectives</h4> To investigate the effect of obesity and fatty liver on muscle area and muscle fat in children and young adults. <h4>Materials and methods</h4> We evaluated consecutive liver fat quantification MRIs in children and young adults between June 2015 and April 2019. We obtained hepatic fat and paraspinal muscle fat at mid L2 from the fat map, psoas muscle area (PMA) at mid L3, and z-score of PMA. The patient’s age, height and weight at the time of the MRI were recorded. Body mass index (BMI) z-score was also calculated. Spearman correlation and partial correlation analyses were performed. Univariate and multivariate regression analyses were also performed using significant variables. <h4>Results</h4> A total of 132 patients (97 male) were included with a median age of 13.0 years (interquartile range 11–16 years). The median BMI was 23.7 kg/m2 (interquartile range 21.2–27.7 kg/m2). The weight, BMI, liver fat, and z-score of PMA were all higher in male patients than they were in female patients. The amount of liver fat had no correlation with muscle fat or PMA z-score after adjusting BMI. However, the BMI z-score was positively correlated with the PMA z-score (ρ = 0.432, p<0.001) even after adjusting for liver fat. On regression analyses, the BMI z-score had linear positive relationship with PMA z-score (β = 0.289, p<0.001) and muscle fat (β = 0.218, p = 0.016). <h4>Conclusions</h4> Male children and young adults have greater PMA than do female children and young adults. Obesity is associated with higher PMA and paraspinal muscle fat. However, liver fat is not related with the muscle condition in children and young adults.Salman S. AlbakheetMi-Jung LeeHaesung YoonHyun Joo ShinHong KohPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Salman S. Albakheet Mi-Jung Lee Haesung Yoon Hyun Joo Shin Hong Koh Psoas muscle area and paraspinal muscle fat in children and young adults with or without obesity and fatty liver
description	<h4>Background</h4> Little is known about the muscle condition in children with obesity. <h4>Objectives</h4> To investigate the effect of obesity and fatty liver on muscle area and muscle fat in children and young adults. <h4>Materials and methods</h4> We evaluated consecutive liver fat quantification MRIs in children and young adults between June 2015 and April 2019. We obtained hepatic fat and paraspinal muscle fat at mid L2 from the fat map, psoas muscle area (PMA) at mid L3, and z-score of PMA. The patient’s age, height and weight at the time of the MRI were recorded. Body mass index (BMI) z-score was also calculated. Spearman correlation and partial correlation analyses were performed. Univariate and multivariate regression analyses were also performed using significant variables. <h4>Results</h4> A total of 132 patients (97 male) were included with a median age of 13.0 years (interquartile range 11–16 years). The median BMI was 23.7 kg/m2 (interquartile range 21.2–27.7 kg/m2). The weight, BMI, liver fat, and z-score of PMA were all higher in male patients than they were in female patients. The amount of liver fat had no correlation with muscle fat or PMA z-score after adjusting BMI. However, the BMI z-score was positively correlated with the PMA z-score (ρ = 0.432, p<0.001) even after adjusting for liver fat. On regression analyses, the BMI z-score had linear positive relationship with PMA z-score (β = 0.289, p<0.001) and muscle fat (β = 0.218, p = 0.016). <h4>Conclusions</h4> Male children and young adults have greater PMA than do female children and young adults. Obesity is associated with higher PMA and paraspinal muscle fat. However, liver fat is not related with the muscle condition in children and young adults.
format	article
author	Salman S. Albakheet Mi-Jung Lee Haesung Yoon Hyun Joo Shin Hong Koh
author_facet	Salman S. Albakheet Mi-Jung Lee Haesung Yoon Hyun Joo Shin Hong Koh
author_sort	Salman S. Albakheet
title	Psoas muscle area and paraspinal muscle fat in children and young adults with or without obesity and fatty liver
title_short	Psoas muscle area and paraspinal muscle fat in children and young adults with or without obesity and fatty liver
title_full	Psoas muscle area and paraspinal muscle fat in children and young adults with or without obesity and fatty liver
title_fullStr	Psoas muscle area and paraspinal muscle fat in children and young adults with or without obesity and fatty liver
title_full_unstemmed	Psoas muscle area and paraspinal muscle fat in children and young adults with or without obesity and fatty liver
title_sort	psoas muscle area and paraspinal muscle fat in children and young adults with or without obesity and fatty liver
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9aa1df6a81ce4575afe2f20933031a7f
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Psoas muscle area and paraspinal muscle fat in children and young adults with or without obesity and fatty liver

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