Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome

Eukaryotic origin firing depends on assembly of the Cdc45-MCM-GINS (CMG) helicase, which requires the leading-strand polymerase Pol ɛ. Here the authors present a structural analysis of a CMG Pol ɛ on a DNA fork, providing insight on the steps leading productive helicase engagement to the DNA junctio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Panchali Goswami, Ferdos Abid Ali, Max E. Douglas, Julia Locke, Andrew Purkiss, Agnieszka Janska, Patrik Eickhoff, Anne Early, Andrea Nans, Alan M. C. Cheung, John F. X. Diffley, Alessandro Costa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9aa43b820ec5447a9b984fff5621c4e6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9aa43b820ec5447a9b984fff5621c4e6
record_format	dspace
spelling	oai:doaj.org-article:9aa43b820ec5447a9b984fff5621c4e62021-12-02T14:41:06ZStructure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome10.1038/s41467-018-07417-12041-1723https://doaj.org/article/9aa43b820ec5447a9b984fff5621c4e62018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07417-1https://doaj.org/toc/2041-1723Eukaryotic origin firing depends on assembly of the Cdc45-MCM-GINS (CMG) helicase, which requires the leading-strand polymerase Pol ɛ. Here the authors present a structural analysis of a CMG Pol ɛ on a DNA fork, providing insight on the steps leading productive helicase engagement to the DNA junction.Panchali GoswamiFerdos Abid AliMax E. DouglasJulia LockeAndrew PurkissAgnieszka JanskaPatrik EickhoffAnne EarlyAndrea NansAlan M. C. CheungJohn F. X. DiffleyAlessandro CostaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Panchali Goswami Ferdos Abid Ali Max E. Douglas Julia Locke Andrew Purkiss Agnieszka Janska Patrik Eickhoff Anne Early Andrea Nans Alan M. C. Cheung John F. X. Diffley Alessandro Costa Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome
description	Eukaryotic origin firing depends on assembly of the Cdc45-MCM-GINS (CMG) helicase, which requires the leading-strand polymerase Pol ɛ. Here the authors present a structural analysis of a CMG Pol ɛ on a DNA fork, providing insight on the steps leading productive helicase engagement to the DNA junction.
format	article
author	Panchali Goswami Ferdos Abid Ali Max E. Douglas Julia Locke Andrew Purkiss Agnieszka Janska Patrik Eickhoff Anne Early Andrea Nans Alan M. C. Cheung John F. X. Diffley Alessandro Costa
author_facet	Panchali Goswami Ferdos Abid Ali Max E. Douglas Julia Locke Andrew Purkiss Agnieszka Janska Patrik Eickhoff Anne Early Andrea Nans Alan M. C. Cheung John F. X. Diffley Alessandro Costa
author_sort	Panchali Goswami
title	Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome
title_short	Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome
title_full	Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome
title_fullStr	Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome
title_full_unstemmed	Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome
title_sort	structure of dna-cmg-pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9aa43b820ec5447a9b984fff5621c4e6
work_keys_str_mv	AT panchaligoswami structureofdnacmgpolepsilonelucidatestherolesofthenoncatalyticpolymerasemodulesintheeukaryoticreplisome AT ferdosabidali structureofdnacmgpolepsilonelucidatestherolesofthenoncatalyticpolymerasemodulesintheeukaryoticreplisome AT maxedouglas structureofdnacmgpolepsilonelucidatestherolesofthenoncatalyticpolymerasemodulesintheeukaryoticreplisome AT julialocke structureofdnacmgpolepsilonelucidatestherolesofthenoncatalyticpolymerasemodulesintheeukaryoticreplisome AT andrewpurkiss structureofdnacmgpolepsilonelucidatestherolesofthenoncatalyticpolymerasemodulesintheeukaryoticreplisome AT agnieszkajanska structureofdnacmgpolepsilonelucidatestherolesofthenoncatalyticpolymerasemodulesintheeukaryoticreplisome AT patrikeickhoff structureofdnacmgpolepsilonelucidatestherolesofthenoncatalyticpolymerasemodulesintheeukaryoticreplisome AT anneearly structureofdnacmgpolepsilonelucidatestherolesofthenoncatalyticpolymerasemodulesintheeukaryoticreplisome AT andreanans structureofdnacmgpolepsilonelucidatestherolesofthenoncatalyticpolymerasemodulesintheeukaryoticreplisome AT alanmccheung structureofdnacmgpolepsilonelucidatestherolesofthenoncatalyticpolymerasemodulesintheeukaryoticreplisome AT johnfxdiffley structureofdnacmgpolepsilonelucidatestherolesofthenoncatalyticpolymerasemodulesintheeukaryoticreplisome AT alessandrocosta structureofdnacmgpolepsilonelucidatestherolesofthenoncatalyticpolymerasemodulesintheeukaryoticreplisome
_version_	1718390008242503680

Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome

Ejemplares similares