A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages

Turning tumour promoting macrophages into an anti-tumour phenotype is an attractive therapeutic strategy. Here, the authors develop a polysaccharide-based structure that mimicks pathogen-associated molecular patterns and, by activating the toll-like receptors on macrophage surface, promotes a safe a...

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Autores principales: Yanxian Feng, Ruoyu Mu, Zhenzhen Wang, Panfei Xing, Junfeng Zhang, Lei Dong, Chunming Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/9aa47db6d2924d21a6cc304bb0016e97
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Sumario:Turning tumour promoting macrophages into an anti-tumour phenotype is an attractive therapeutic strategy. Here, the authors develop a polysaccharide-based structure that mimicks pathogen-associated molecular patterns and, by activating the toll-like receptors on macrophage surface, promotes a safe anti-tumour immune response in mouse models.