A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages

A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages

Turning tumour promoting macrophages into an anti-tumour phenotype is an attractive therapeutic strategy. Here, the authors develop a polysaccharide-based structure that mimicks pathogen-associated molecular patterns and, by activating the toll-like receptors on macrophage surface, promotes a safe a...

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Autores principales: Yanxian Feng, Ruoyu Mu, Zhenzhen Wang, Panfei Xing, Junfeng Zhang, Lei Dong, Chunming Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/9aa47db6d2924d21a6cc304bb0016e97
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spelling oai:doaj.org-article:9aa47db6d2924d21a6cc304bb0016e972021-12-02T17:01:59ZA toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages10.1038/s41467-019-10354-22041-1723https://doaj.org/article/9aa47db6d2924d21a6cc304bb0016e972019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10354-2https://doaj.org/toc/2041-1723Turning tumour promoting macrophages into an anti-tumour phenotype is an attractive therapeutic strategy. Here, the authors develop a polysaccharide-based structure that mimicks pathogen-associated molecular patterns and, by activating the toll-like receptors on macrophage surface, promotes a safe anti-tumour immune response in mouse models.Yanxian FengRuoyu MuZhenzhen WangPanfei XingJunfeng ZhangLei DongChunming WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yanxian Feng
Ruoyu Mu
Zhenzhen Wang
Panfei Xing
Junfeng Zhang
Lei Dong
Chunming Wang
A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages
description Turning tumour promoting macrophages into an anti-tumour phenotype is an attractive therapeutic strategy. Here, the authors develop a polysaccharide-based structure that mimicks pathogen-associated molecular patterns and, by activating the toll-like receptors on macrophage surface, promotes a safe anti-tumour immune response in mouse models.
format article
author Yanxian Feng
Ruoyu Mu
Zhenzhen Wang
Panfei Xing
Junfeng Zhang
Lei Dong
Chunming Wang
author_facet Yanxian Feng
Ruoyu Mu
Zhenzhen Wang
Panfei Xing
Junfeng Zhang
Lei Dong
Chunming Wang
author_sort Yanxian Feng
title A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages
title_short A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages
title_full A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages
title_fullStr A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages
title_full_unstemmed A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages
title_sort toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/9aa47db6d2924d21a6cc304bb0016e97
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