High-throughput screen reveals sRNAs regulating crRNA biogenesis by targeting CRISPR leader to repress Rho termination

Small non-coding RNAs (sRNA) regulate bacterial functions by finding nucleic acids and proteins. Here the authors identify PhrS sRNA in Pseudomonas as a positive regulator of CRISPR, and show PhrS acts by binding to CRISPR leader, thereby preventing Rho-mediated transcription termination and promoti...

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Autores principales:	Ping Lin, Qinqin Pu, Qun Wu, Chuanmin Zhou, Biao Wang, Jacob Schettler, Zhihan Wang, Shugang Qin, Pan Gao, Rongpeng Li, Guoping Li, Zhenyu Cheng, Lefu Lan, Jianxin Jiang, Min Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9aabe318c6e346aebdf2408f9a2e06b6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:9aabe318c6e346aebdf2408f9a2e06b62021-12-02T15:35:49ZHigh-throughput screen reveals sRNAs regulating crRNA biogenesis by targeting CRISPR leader to repress Rho termination10.1038/s41467-019-11695-82041-1723https://doaj.org/article/9aabe318c6e346aebdf2408f9a2e06b62019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11695-8https://doaj.org/toc/2041-1723Small non-coding RNAs (sRNA) regulate bacterial functions by finding nucleic acids and proteins. Here the authors identify PhrS sRNA in Pseudomonas as a positive regulator of CRISPR, and show PhrS acts by binding to CRISPR leader, thereby preventing Rho-mediated transcription termination and promoting anti-bacteriophage immunity.Ping LinQinqin PuQun WuChuanmin ZhouBiao WangJacob SchettlerZhihan WangShugang QinPan GaoRongpeng LiGuoping LiZhenyu ChengLefu LanJianxin JiangMin WuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ping Lin Qinqin Pu Qun Wu Chuanmin Zhou Biao Wang Jacob Schettler Zhihan Wang Shugang Qin Pan Gao Rongpeng Li Guoping Li Zhenyu Cheng Lefu Lan Jianxin Jiang Min Wu High-throughput screen reveals sRNAs regulating crRNA biogenesis by targeting CRISPR leader to repress Rho termination
description	Small non-coding RNAs (sRNA) regulate bacterial functions by finding nucleic acids and proteins. Here the authors identify PhrS sRNA in Pseudomonas as a positive regulator of CRISPR, and show PhrS acts by binding to CRISPR leader, thereby preventing Rho-mediated transcription termination and promoting anti-bacteriophage immunity.
format	article
author	Ping Lin Qinqin Pu Qun Wu Chuanmin Zhou Biao Wang Jacob Schettler Zhihan Wang Shugang Qin Pan Gao Rongpeng Li Guoping Li Zhenyu Cheng Lefu Lan Jianxin Jiang Min Wu
author_facet	Ping Lin Qinqin Pu Qun Wu Chuanmin Zhou Biao Wang Jacob Schettler Zhihan Wang Shugang Qin Pan Gao Rongpeng Li Guoping Li Zhenyu Cheng Lefu Lan Jianxin Jiang Min Wu
author_sort	Ping Lin
title	High-throughput screen reveals sRNAs regulating crRNA biogenesis by targeting CRISPR leader to repress Rho termination
title_short	High-throughput screen reveals sRNAs regulating crRNA biogenesis by targeting CRISPR leader to repress Rho termination
title_full	High-throughput screen reveals sRNAs regulating crRNA biogenesis by targeting CRISPR leader to repress Rho termination
title_fullStr	High-throughput screen reveals sRNAs regulating crRNA biogenesis by targeting CRISPR leader to repress Rho termination
title_full_unstemmed	High-throughput screen reveals sRNAs regulating crRNA biogenesis by targeting CRISPR leader to repress Rho termination
title_sort	high-throughput screen reveals srnas regulating crrna biogenesis by targeting crispr leader to repress rho termination
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9aabe318c6e346aebdf2408f9a2e06b6
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High-throughput screen reveals sRNAs regulating crRNA biogenesis by targeting CRISPR leader to repress Rho termination

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