High-throughput screen reveals sRNAs regulating crRNA biogenesis by targeting CRISPR leader to repress Rho termination

High-throughput screen reveals sRNAs regulating crRNA biogenesis by targeting CRISPR leader to repress Rho termination

Small non-coding RNAs (sRNA) regulate bacterial functions by finding nucleic acids and proteins. Here the authors identify PhrS sRNA in Pseudomonas as a positive regulator of CRISPR, and show PhrS acts by binding to CRISPR leader, thereby preventing Rho-mediated transcription termination and promoti...

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Main Authors: Ping Lin, Qinqin Pu, Qun Wu, Chuanmin Zhou, Biao Wang, Jacob Schettler, Zhihan Wang, Shugang Qin, Pan Gao, Rongpeng Li, Guoping Li, Zhenyu Cheng, Lefu Lan, Jianxin Jiang, Min Wu
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/9aabe318c6e346aebdf2408f9a2e06b6
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https://doaj.org/article/9aabe318c6e346aebdf2408f9a2e06b6

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