Biophysical evaluation of cells on nanotubular surfaces: the effects of atomic ordering and chemistry

Tolou Shokuhfar,1–3 Azhang Hamlekhan,1 Jen-Yung Chang,1 Chang Kyoung Choi,1 Cortino Sukotjo,4 Craig Friedrich11Department of Mechanical Engineering-Engineering Mechanics, Multi Scale Technologies Institute, Michigan Technological University, Houghton, MI, 2Department of Physics, Universit...

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Autores principales:	Shokuhfar T, Hamlekhan A, Chang JY, Choi CK, Sukotjo C, Friedrich C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9ab08333ee2d4c258a9145b226d34bb3
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spelling	oai:doaj.org-article:9ab08333ee2d4c258a9145b226d34bb32021-12-02T03:58:32ZBiophysical evaluation of cells on nanotubular surfaces: the effects of atomic ordering and chemistry1178-2013https://doaj.org/article/9ab08333ee2d4c258a9145b226d34bb32014-08-01T00:00:00Zhttp://www.dovepress.com/biophysical-evaluation-of-cells-on-nanotubular-surfaces-the-effects-of-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Tolou Shokuhfar,1–3 Azhang Hamlekhan,1 Jen-Yung Chang,1 Chang Kyoung Choi,1 Cortino Sukotjo,4 Craig Friedrich11Department of Mechanical Engineering-Engineering Mechanics, Multi Scale Technologies Institute, Michigan Technological University, Houghton, MI, 2Department of Physics, University of Illinois at Chicago, Chicago, IL, 3Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, IL, 4Department of Restorative Dentistry, Comprehensive Dental Implant Center, University of Illinois at Chicago, College of Dentistry, Chicago, IL, USAAbstract: After the implantation of a biomaterial in the body, the first interaction occurs between the cells in contact with the biomaterial surface. Therefore, evaluating the cell–substrate interface is crucial for designing a successful implant. In this study, the interaction of MC3T3 osteoblasts was studied on commercially pure and alloy (Ti6Al4V) Ti surfaces treated with amorphous and crystalline titanium dioxide nanotubes. The results indicated that the presence of nanotubes increased the density of osteoblast cells in comparison to bare surfaces (no nanotubes). More importantly, our finding shows that the chemistry of the substrate affects the cell density rather than the morphology of the cells. A novel approach based on the focused ion beam technique was used to investigate the biophysical cell–substrate interaction. The analysis revealed that portions of the cells migrated inside the crystalline nanotubes. This observation was correlated with the super hydrophilic properties of the crystalline nanotubes. Keywords: nanotubes, osteoblasts, titanium dioxideShokuhfar THamlekhan AChang JYChoi CKSukotjo CFriedrich CDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 3737-3748 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Shokuhfar T Hamlekhan A Chang JY Choi CK Sukotjo C Friedrich C Biophysical evaluation of cells on nanotubular surfaces: the effects of atomic ordering and chemistry
description	Tolou Shokuhfar,1–3 Azhang Hamlekhan,1 Jen-Yung Chang,1 Chang Kyoung Choi,1 Cortino Sukotjo,4 Craig Friedrich11Department of Mechanical Engineering-Engineering Mechanics, Multi Scale Technologies Institute, Michigan Technological University, Houghton, MI, 2Department of Physics, University of Illinois at Chicago, Chicago, IL, 3Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, IL, 4Department of Restorative Dentistry, Comprehensive Dental Implant Center, University of Illinois at Chicago, College of Dentistry, Chicago, IL, USAAbstract: After the implantation of a biomaterial in the body, the first interaction occurs between the cells in contact with the biomaterial surface. Therefore, evaluating the cell–substrate interface is crucial for designing a successful implant. In this study, the interaction of MC3T3 osteoblasts was studied on commercially pure and alloy (Ti6Al4V) Ti surfaces treated with amorphous and crystalline titanium dioxide nanotubes. The results indicated that the presence of nanotubes increased the density of osteoblast cells in comparison to bare surfaces (no nanotubes). More importantly, our finding shows that the chemistry of the substrate affects the cell density rather than the morphology of the cells. A novel approach based on the focused ion beam technique was used to investigate the biophysical cell–substrate interaction. The analysis revealed that portions of the cells migrated inside the crystalline nanotubes. This observation was correlated with the super hydrophilic properties of the crystalline nanotubes. Keywords: nanotubes, osteoblasts, titanium dioxide
format	article
author	Shokuhfar T Hamlekhan A Chang JY Choi CK Sukotjo C Friedrich C
author_facet	Shokuhfar T Hamlekhan A Chang JY Choi CK Sukotjo C Friedrich C
author_sort	Shokuhfar T
title	Biophysical evaluation of cells on nanotubular surfaces: the effects of atomic ordering and chemistry
title_short	Biophysical evaluation of cells on nanotubular surfaces: the effects of atomic ordering and chemistry
title_full	Biophysical evaluation of cells on nanotubular surfaces: the effects of atomic ordering and chemistry
title_fullStr	Biophysical evaluation of cells on nanotubular surfaces: the effects of atomic ordering and chemistry
title_full_unstemmed	Biophysical evaluation of cells on nanotubular surfaces: the effects of atomic ordering and chemistry
title_sort	biophysical evaluation of cells on nanotubular surfaces: the effects of atomic ordering and chemistry
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/9ab08333ee2d4c258a9145b226d34bb3
work_keys_str_mv	AT shokuhfart biophysicalevaluationofcellsonnanotubularsurfacestheeffectsofatomicorderingandchemistry AT hamlekhana biophysicalevaluationofcellsonnanotubularsurfacestheeffectsofatomicorderingandchemistry AT changjy biophysicalevaluationofcellsonnanotubularsurfacestheeffectsofatomicorderingandchemistry AT choick biophysicalevaluationofcellsonnanotubularsurfacestheeffectsofatomicorderingandchemistry AT sukotjoc biophysicalevaluationofcellsonnanotubularsurfacestheeffectsofatomicorderingandchemistry AT friedrichc biophysicalevaluationofcellsonnanotubularsurfacestheeffectsofatomicorderingandchemistry
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Biophysical evaluation of cells on nanotubular surfaces: the effects of atomic ordering and chemistry

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