CryoET structures of immature HIV Gag reveal six-helix bundle

Mendonça et al. determine the structures of both in vitro assemblies of the HIV structural precursor protein Gag and Gag viral-like particles (VLPs) to 4.2 Å and 4.5 Å resolutions, using cryo-electron tomography and subtomogram averaging. This study provides insights into the future development of s...

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Autores principales:	Luiza Mendonça, Dapeng Sun, Jiying Ning, Jiwei Liu, Abhay Kotecha, Mateusz Olek, Thomas Frosio, Xiaofeng Fu, Benjamin A. Himes, Alex B. Kleinpeter, Eric O. Freed, Jing Zhou, Christopher Aiken, Peijun Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9ab2d7c26554447ba2a91fac3949925b
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spelling	oai:doaj.org-article:9ab2d7c26554447ba2a91fac3949925b2021-12-02T14:30:33ZCryoET structures of immature HIV Gag reveal six-helix bundle10.1038/s42003-021-01999-12399-3642https://doaj.org/article/9ab2d7c26554447ba2a91fac3949925b2021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01999-1https://doaj.org/toc/2399-3642Mendonça et al. determine the structures of both in vitro assemblies of the HIV structural precursor protein Gag and Gag viral-like particles (VLPs) to 4.2 Å and 4.5 Å resolutions, using cryo-electron tomography and subtomogram averaging. This study provides insights into the future development of small molecule inhibitors for HIV-1 infection.Luiza MendonçaDapeng SunJiying NingJiwei LiuAbhay KotechaMateusz OlekThomas FrosioXiaofeng FuBenjamin A. HimesAlex B. KleinpeterEric O. FreedJing ZhouChristopher AikenPeijun ZhangNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Luiza Mendonça Dapeng Sun Jiying Ning Jiwei Liu Abhay Kotecha Mateusz Olek Thomas Frosio Xiaofeng Fu Benjamin A. Himes Alex B. Kleinpeter Eric O. Freed Jing Zhou Christopher Aiken Peijun Zhang CryoET structures of immature HIV Gag reveal six-helix bundle
description	Mendonça et al. determine the structures of both in vitro assemblies of the HIV structural precursor protein Gag and Gag viral-like particles (VLPs) to 4.2 Å and 4.5 Å resolutions, using cryo-electron tomography and subtomogram averaging. This study provides insights into the future development of small molecule inhibitors for HIV-1 infection.
format	article
author	Luiza Mendonça Dapeng Sun Jiying Ning Jiwei Liu Abhay Kotecha Mateusz Olek Thomas Frosio Xiaofeng Fu Benjamin A. Himes Alex B. Kleinpeter Eric O. Freed Jing Zhou Christopher Aiken Peijun Zhang
author_facet	Luiza Mendonça Dapeng Sun Jiying Ning Jiwei Liu Abhay Kotecha Mateusz Olek Thomas Frosio Xiaofeng Fu Benjamin A. Himes Alex B. Kleinpeter Eric O. Freed Jing Zhou Christopher Aiken Peijun Zhang
author_sort	Luiza Mendonça
title	CryoET structures of immature HIV Gag reveal six-helix bundle
title_short	CryoET structures of immature HIV Gag reveal six-helix bundle
title_full	CryoET structures of immature HIV Gag reveal six-helix bundle
title_fullStr	CryoET structures of immature HIV Gag reveal six-helix bundle
title_full_unstemmed	CryoET structures of immature HIV Gag reveal six-helix bundle
title_sort	cryoet structures of immature hiv gag reveal six-helix bundle
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9ab2d7c26554447ba2a91fac3949925b
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CryoET structures of immature HIV Gag reveal six-helix bundle

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