The effect of obstructive sleep apnea on peripheral blood amino acid and biogenic amine metabolome at multiple time points overnight

Abstract There are no clinical studies that have investigated the differences in blood serum metabolome between obstructive sleep apnea (OSA) patients and controls. In a single-center prospective observational study, we compared metabolomic profiles in the serum of OSA patients with apnea–hypopnea i...

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Autores principales:	Ott Kiens, Egon Taalberg, Viktoria Ivanova, Ketlin Veeväli, Triin Laurits, Ragne Tamm, Aigar Ottas, Kalle Kilk, Ursel Soomets, Alan Altraja
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9ab2f606810e46d7a27d8978cc1a1e17
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spelling	oai:doaj.org-article:9ab2f606810e46d7a27d8978cc1a1e172021-12-02T14:49:25ZThe effect of obstructive sleep apnea on peripheral blood amino acid and biogenic amine metabolome at multiple time points overnight10.1038/s41598-021-88409-y2045-2322https://doaj.org/article/9ab2f606810e46d7a27d8978cc1a1e172021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88409-yhttps://doaj.org/toc/2045-2322Abstract There are no clinical studies that have investigated the differences in blood serum metabolome between obstructive sleep apnea (OSA) patients and controls. In a single-center prospective observational study, we compared metabolomic profiles in the serum of OSA patients with apnea–hypopnea index (AHI) ≥ 15/h and control individuals. Peripheral blood was obtained at 3 different time points overnight: 9:00 p.m.; 5:00 a.m. and 7:00 a.m. We used a targeted approach for detecting amino acids and biogenic amines and analyzed the data with ranked general linear model for repeated measures. We recruited 31 patients with moderate-to-severe OSA and 32 controls. Significant elevations in median concentrations of alanine, proline and kynurenine in OSA patients compared to controls were detected. Significant changes in the overnight dynamics of serum concentrations occurred in OSA: glutamine, serine, threonine, tryptophan, kynurenine and glycine levels increased, whereas a fall occurred in the same biomarker levels in controls. Phenylalanine and proline levels decreased slightly, compared to a steeper fall in controls. The study indicates that serum profiles of amino acid and biogenic amines are significantly altered in patients with OSA referring to vast pathophysiologic shifts reflected in the systemic metabolism.Ott KiensEgon TaalbergViktoria IvanovaKetlin VeeväliTriin LauritsRagne TammAigar OttasKalle KilkUrsel SoometsAlan AltrajaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ott Kiens Egon Taalberg Viktoria Ivanova Ketlin Veeväli Triin Laurits Ragne Tamm Aigar Ottas Kalle Kilk Ursel Soomets Alan Altraja The effect of obstructive sleep apnea on peripheral blood amino acid and biogenic amine metabolome at multiple time points overnight
description	Abstract There are no clinical studies that have investigated the differences in blood serum metabolome between obstructive sleep apnea (OSA) patients and controls. In a single-center prospective observational study, we compared metabolomic profiles in the serum of OSA patients with apnea–hypopnea index (AHI) ≥ 15/h and control individuals. Peripheral blood was obtained at 3 different time points overnight: 9:00 p.m.; 5:00 a.m. and 7:00 a.m. We used a targeted approach for detecting amino acids and biogenic amines and analyzed the data with ranked general linear model for repeated measures. We recruited 31 patients with moderate-to-severe OSA and 32 controls. Significant elevations in median concentrations of alanine, proline and kynurenine in OSA patients compared to controls were detected. Significant changes in the overnight dynamics of serum concentrations occurred in OSA: glutamine, serine, threonine, tryptophan, kynurenine and glycine levels increased, whereas a fall occurred in the same biomarker levels in controls. Phenylalanine and proline levels decreased slightly, compared to a steeper fall in controls. The study indicates that serum profiles of amino acid and biogenic amines are significantly altered in patients with OSA referring to vast pathophysiologic shifts reflected in the systemic metabolism.
format	article
author	Ott Kiens Egon Taalberg Viktoria Ivanova Ketlin Veeväli Triin Laurits Ragne Tamm Aigar Ottas Kalle Kilk Ursel Soomets Alan Altraja
author_facet	Ott Kiens Egon Taalberg Viktoria Ivanova Ketlin Veeväli Triin Laurits Ragne Tamm Aigar Ottas Kalle Kilk Ursel Soomets Alan Altraja
author_sort	Ott Kiens
title	The effect of obstructive sleep apnea on peripheral blood amino acid and biogenic amine metabolome at multiple time points overnight
title_short	The effect of obstructive sleep apnea on peripheral blood amino acid and biogenic amine metabolome at multiple time points overnight
title_full	The effect of obstructive sleep apnea on peripheral blood amino acid and biogenic amine metabolome at multiple time points overnight
title_fullStr	The effect of obstructive sleep apnea on peripheral blood amino acid and biogenic amine metabolome at multiple time points overnight
title_full_unstemmed	The effect of obstructive sleep apnea on peripheral blood amino acid and biogenic amine metabolome at multiple time points overnight
title_sort	effect of obstructive sleep apnea on peripheral blood amino acid and biogenic amine metabolome at multiple time points overnight
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9ab2f606810e46d7a27d8978cc1a1e17
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The effect of obstructive sleep apnea on peripheral blood amino acid and biogenic amine metabolome at multiple time points overnight

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