The TOMM40 ‘523’ polymorphism in disease risk and age of symptom onset in two independent cohorts of Parkinson’s disease

The TOMM40 ‘523’ polymorphism in disease risk and age of symptom onset in two independent cohorts of Parkinson’s disease

Abstract Abnormal mitochondrial function is a key process in the pathogenesis of Parkinson’s disease (PD). The central pore-forming protein TOM40 of the mitochondria is encoded by the translocase of outer mitochondrial membrane 40 homologue gene (TOMM40). The highly variant ‘523’ poly-T repeat is as...

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Autores principales: Megan C. Bakeberg, Madison E. Hoes, Anastazja M. Gorecki, Frances Theunissen, Abigail L. Pfaff, Jade E. Kenna, Kai Plunkett, Sulev Kõks, P. Anthony Akkari, Frank L. Mastaglia, Ryan S. Anderton
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/9ab3223bbabf470e8f6e3a4036bbd687
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