Evolution of a G protein-coupled receptor response by mutations in regulatory network interactions

Co-evolution of a new receptor-ligand pair will affect the downstream signal transduction network. Here, the authors use experimental evolution of yeast mating receptor Ste2 to show the effect of enhanced binding affinity and weakened interactions with the network's negative regulators on prote...

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Autores principales:	Raphaël B. Di Roberto, Belinda Chang, Ala Trusina, Sergio G. Peisajovich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9ab4275031444dcfa4916e9056cc45fb
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spelling	oai:doaj.org-article:9ab4275031444dcfa4916e9056cc45fb2021-12-02T15:34:51ZEvolution of a G protein-coupled receptor response by mutations in regulatory network interactions10.1038/ncomms123442041-1723https://doaj.org/article/9ab4275031444dcfa4916e9056cc45fb2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12344https://doaj.org/toc/2041-1723Co-evolution of a new receptor-ligand pair will affect the downstream signal transduction network. Here, the authors use experimental evolution of yeast mating receptor Ste2 to show the effect of enhanced binding affinity and weakened interactions with the network's negative regulators on protein evolution.Raphaël B. Di RobertoBelinda ChangAla TrusinaSergio G. PeisajovichNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Raphaël B. Di Roberto Belinda Chang Ala Trusina Sergio G. Peisajovich Evolution of a G protein-coupled receptor response by mutations in regulatory network interactions
description	Co-evolution of a new receptor-ligand pair will affect the downstream signal transduction network. Here, the authors use experimental evolution of yeast mating receptor Ste2 to show the effect of enhanced binding affinity and weakened interactions with the network's negative regulators on protein evolution.
format	article
author	Raphaël B. Di Roberto Belinda Chang Ala Trusina Sergio G. Peisajovich
author_facet	Raphaël B. Di Roberto Belinda Chang Ala Trusina Sergio G. Peisajovich
author_sort	Raphaël B. Di Roberto
title	Evolution of a G protein-coupled receptor response by mutations in regulatory network interactions
title_short	Evolution of a G protein-coupled receptor response by mutations in regulatory network interactions
title_full	Evolution of a G protein-coupled receptor response by mutations in regulatory network interactions
title_fullStr	Evolution of a G protein-coupled receptor response by mutations in regulatory network interactions
title_full_unstemmed	Evolution of a G protein-coupled receptor response by mutations in regulatory network interactions
title_sort	evolution of a g protein-coupled receptor response by mutations in regulatory network interactions
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9ab4275031444dcfa4916e9056cc45fb
work_keys_str_mv	AT raphaelbdiroberto evolutionofagproteincoupledreceptorresponsebymutationsinregulatorynetworkinteractions AT belindachang evolutionofagproteincoupledreceptorresponsebymutationsinregulatorynetworkinteractions AT alatrusina evolutionofagproteincoupledreceptorresponsebymutationsinregulatorynetworkinteractions AT sergiogpeisajovich evolutionofagproteincoupledreceptorresponsebymutationsinregulatorynetworkinteractions
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Evolution of a G protein-coupled receptor response by mutations in regulatory network interactions

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