Evolution of a G protein-coupled receptor response by mutations in regulatory network interactions

Evolution of a G protein-coupled receptor response by mutations in regulatory network interactions

Co-evolution of a new receptor-ligand pair will affect the downstream signal transduction network. Here, the authors use experimental evolution of yeast mating receptor Ste2 to show the effect of enhanced binding affinity and weakened interactions with the network's negative regulators on prote...

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Autores principales: Raphaël B. Di Roberto, Belinda Chang, Ala Trusina, Sergio G. Peisajovich
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
Q
Acceso en línea:https://doaj.org/article/9ab4275031444dcfa4916e9056cc45fb
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