Preservation of auditory P300-like potentials in cortical deafness.

The phenomenon of blindsight has been largely studied and refers to residual abilities of blind patients without an acknowledged visual awareness. Similarly, "deaf hearing" might represent a further example of dissociation between detection and perception of sounds. Here we report the rare...

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Autores principales:	Marianna Cavinato, Jessica Rigon, Chiara Volpato, Carlo Semenza, Francesco Piccione
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9ab7ab0df9fc40078d8d5c7a822bd3c8
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spelling	oai:doaj.org-article:9ab7ab0df9fc40078d8d5c7a822bd3c82021-11-18T07:30:12ZPreservation of auditory P300-like potentials in cortical deafness.1932-620310.1371/journal.pone.0029909https://doaj.org/article/9ab7ab0df9fc40078d8d5c7a822bd3c82012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22272260/?tool=EBIhttps://doaj.org/toc/1932-6203The phenomenon of blindsight has been largely studied and refers to residual abilities of blind patients without an acknowledged visual awareness. Similarly, "deaf hearing" might represent a further example of dissociation between detection and perception of sounds. Here we report the rare case of a patient with a persistent and complete cortical deafness caused by damage to the bilateral temporo-parietal lobes who occasionally showed unexpected reactions to environmental sounds despite she denied hearing. We applied for the first time electrophysiological techniques to better understand auditory processing and perceptual awareness of the patient. While auditory brainstem responses were within normal limits, no middle- and long-latency waveforms could be identified. However, event-related potentials showed conflicting results. While the Mismatch Negativity could not be evoked, robust P3-like waveforms were surprisingly found in the latency range of 600-700 ms. The generation of P3-like potentials, despite extensive destruction of the auditory cortex, might imply the integrity of independent circuits necessary to process auditory stimuli even in the absence of consciousness of sound. Our results support the reverse hierarchy theory that asserts that the higher levels of the hierarchy are immediately available for perception, while low-level information requires more specific conditions. The accurate characterization in terms of anatomy and neurophysiology of the auditory lesions might facilitate understanding of the neural substrates involved in deaf-hearing.Marianna CavinatoJessica RigonChiara VolpatoCarlo SemenzaFrancesco PiccionePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e29909 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marianna Cavinato Jessica Rigon Chiara Volpato Carlo Semenza Francesco Piccione Preservation of auditory P300-like potentials in cortical deafness.
description	The phenomenon of blindsight has been largely studied and refers to residual abilities of blind patients without an acknowledged visual awareness. Similarly, "deaf hearing" might represent a further example of dissociation between detection and perception of sounds. Here we report the rare case of a patient with a persistent and complete cortical deafness caused by damage to the bilateral temporo-parietal lobes who occasionally showed unexpected reactions to environmental sounds despite she denied hearing. We applied for the first time electrophysiological techniques to better understand auditory processing and perceptual awareness of the patient. While auditory brainstem responses were within normal limits, no middle- and long-latency waveforms could be identified. However, event-related potentials showed conflicting results. While the Mismatch Negativity could not be evoked, robust P3-like waveforms were surprisingly found in the latency range of 600-700 ms. The generation of P3-like potentials, despite extensive destruction of the auditory cortex, might imply the integrity of independent circuits necessary to process auditory stimuli even in the absence of consciousness of sound. Our results support the reverse hierarchy theory that asserts that the higher levels of the hierarchy are immediately available for perception, while low-level information requires more specific conditions. The accurate characterization in terms of anatomy and neurophysiology of the auditory lesions might facilitate understanding of the neural substrates involved in deaf-hearing.
format	article
author	Marianna Cavinato Jessica Rigon Chiara Volpato Carlo Semenza Francesco Piccione
author_facet	Marianna Cavinato Jessica Rigon Chiara Volpato Carlo Semenza Francesco Piccione
author_sort	Marianna Cavinato
title	Preservation of auditory P300-like potentials in cortical deafness.
title_short	Preservation of auditory P300-like potentials in cortical deafness.
title_full	Preservation of auditory P300-like potentials in cortical deafness.
title_fullStr	Preservation of auditory P300-like potentials in cortical deafness.
title_full_unstemmed	Preservation of auditory P300-like potentials in cortical deafness.
title_sort	preservation of auditory p300-like potentials in cortical deafness.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/9ab7ab0df9fc40078d8d5c7a822bd3c8
work_keys_str_mv	AT mariannacavinato preservationofauditoryp300likepotentialsincorticaldeafness AT jessicarigon preservationofauditoryp300likepotentialsincorticaldeafness AT chiaravolpato preservationofauditoryp300likepotentialsincorticaldeafness AT carlosemenza preservationofauditoryp300likepotentialsincorticaldeafness AT francescopiccione preservationofauditoryp300likepotentialsincorticaldeafness
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Preservation of auditory P300-like potentials in cortical deafness.

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