Controlled release of 5-fluorouracil and progesterone from magnetic nanoaggregates

Doaa M Ragab,1 Sohrab Rohani,1 Styliani Consta21Department of Chemical and Biochemical Engineering, 2Department of Chemistry, The University of Western Ontario, London, Ontario, CanadaBackground: The potential use of magnetic nanoparticles in biomedical applications has witnessed an exponential grow...

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Autores principales:	Ragab DM, Rohani S, Consta S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9ab7f1643fbd4b83a830218f8f2ff8f0
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spelling	oai:doaj.org-article:9ab7f1643fbd4b83a830218f8f2ff8f02021-12-02T02:49:04ZControlled release of 5-fluorouracil and progesterone from magnetic nanoaggregates1176-91141178-2013https://doaj.org/article/9ab7f1643fbd4b83a830218f8f2ff8f02012-06-01T00:00:00Zhttp://www.dovepress.com/controlled-release-of-5-fluorouracil-and-progesterone-from-magnetic-na-a10257https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Doaa M Ragab,1 Sohrab Rohani,1 Styliani Consta21Department of Chemical and Biochemical Engineering, 2Department of Chemistry, The University of Western Ontario, London, Ontario, CanadaBackground: The potential use of magnetic nanoparticles in biomedical applications has witnessed an exponential growth in recent years.Methods: In this study, we used nanoaggregates of magnetic nanoparticles as carriers for controlled drug delivery. The nanoaggregates are formed due to the presence of the block copolymer of polyethylene oxide-polypropylene oxide (Pluronic F-68) and beta-cyclodextrin that surround the magnetic core of the nanoparticles. The administration of the drug carriers occurs by inhalation, and the drug is delivered systemically via the pulmonary route. We tested the delivery of 5-fluorouracil and progesterone, which are used as models of hydrophilic and hydrophobic drugs, respectively.Results: The estimated nanoaggregates&#39; diameters are between 293 nm &plusmn; 14.65 nm and 90.2 nm &plusmn; 4.51 nm, respectively. In-situ and post-synthesis techniques are two approaches for drug loading. The polymer composition of nanoaggregates and initial drug concentration showed a significant effect on both the drug entrapment efficiency and release kinetics. Average drug entrapment efficiencies ranged between 16.11% and 83.25%. In-situ loaded samples showed significantly slower release rates. The drug release mechanism is investigated by mathematical curve fitting to different drug release kinetics models. In most cases, the Peppas model has shown good correlations (coefficients of correlation, R2, between 0.85 and 0.99) with the examined release profiles. The estimated release indices are below 0.5, which indicates the Fickian diffusion mechanism. For samples with an initial burst effect, the modified Peppas model can provide a better understanding of the drug release mechanism, both in the samples loaded with progesterone, or those high polymer concentrations.Conclusion: Our work showed prolonged delivery of drugs (5-fluorouracil and progesterone) by diffusion from nanoaggregates, with the potential to reduce dose-related adverse effects.Keywords: Nanoaggregates, 5-fluorouracil, progesterone, release kinetics, Fickian diffusionRagab DMRohani SConsta SDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 3167-3189 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Ragab DM Rohani S Consta S Controlled release of 5-fluorouracil and progesterone from magnetic nanoaggregates
description	Doaa M Ragab,1 Sohrab Rohani,1 Styliani Consta21Department of Chemical and Biochemical Engineering, 2Department of Chemistry, The University of Western Ontario, London, Ontario, CanadaBackground: The potential use of magnetic nanoparticles in biomedical applications has witnessed an exponential growth in recent years.Methods: In this study, we used nanoaggregates of magnetic nanoparticles as carriers for controlled drug delivery. The nanoaggregates are formed due to the presence of the block copolymer of polyethylene oxide-polypropylene oxide (Pluronic F-68) and beta-cyclodextrin that surround the magnetic core of the nanoparticles. The administration of the drug carriers occurs by inhalation, and the drug is delivered systemically via the pulmonary route. We tested the delivery of 5-fluorouracil and progesterone, which are used as models of hydrophilic and hydrophobic drugs, respectively.Results: The estimated nanoaggregates&#39; diameters are between 293 nm &plusmn; 14.65 nm and 90.2 nm &plusmn; 4.51 nm, respectively. In-situ and post-synthesis techniques are two approaches for drug loading. The polymer composition of nanoaggregates and initial drug concentration showed a significant effect on both the drug entrapment efficiency and release kinetics. Average drug entrapment efficiencies ranged between 16.11% and 83.25%. In-situ loaded samples showed significantly slower release rates. The drug release mechanism is investigated by mathematical curve fitting to different drug release kinetics models. In most cases, the Peppas model has shown good correlations (coefficients of correlation, R2, between 0.85 and 0.99) with the examined release profiles. The estimated release indices are below 0.5, which indicates the Fickian diffusion mechanism. For samples with an initial burst effect, the modified Peppas model can provide a better understanding of the drug release mechanism, both in the samples loaded with progesterone, or those high polymer concentrations.Conclusion: Our work showed prolonged delivery of drugs (5-fluorouracil and progesterone) by diffusion from nanoaggregates, with the potential to reduce dose-related adverse effects.Keywords: Nanoaggregates, 5-fluorouracil, progesterone, release kinetics, Fickian diffusion
format	article
author	Ragab DM Rohani S Consta S
author_facet	Ragab DM Rohani S Consta S
author_sort	Ragab DM
title	Controlled release of 5-fluorouracil and progesterone from magnetic nanoaggregates
title_short	Controlled release of 5-fluorouracil and progesterone from magnetic nanoaggregates
title_full	Controlled release of 5-fluorouracil and progesterone from magnetic nanoaggregates
title_fullStr	Controlled release of 5-fluorouracil and progesterone from magnetic nanoaggregates
title_full_unstemmed	Controlled release of 5-fluorouracil and progesterone from magnetic nanoaggregates
title_sort	controlled release of 5-fluorouracil and progesterone from magnetic nanoaggregates
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/9ab7f1643fbd4b83a830218f8f2ff8f0
work_keys_str_mv	AT ragabdm controlledreleaseof5fluorouracilandprogesteronefrommagneticnanoaggregates AT rohanis controlledreleaseof5fluorouracilandprogesteronefrommagneticnanoaggregates AT constas controlledreleaseof5fluorouracilandprogesteronefrommagneticnanoaggregates
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Controlled release of 5-fluorouracil and progesterone from magnetic nanoaggregates

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