Efficient base editing for multiple genes and loci in pigs using base editors

Base editors can efficiently produce single nucleotide alterations without requiring a double-strand break. Here the authors show base editing at multiple sites simultaneously in pigs.

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Autores principales:	Jingke Xie, Weikai Ge, Nan Li, Qishuai Liu, Fangbing Chen, Xiaoyu Yang, Xingyun Huang, Zhen Ouyang, Quanjun Zhang, Yu Zhao, Zhaoming Liu, Shixue Gou, Han Wu, Chengdan Lai, Nana Fan, Qin Jin, Hui Shi, Yanhui Liang, Ting Lan, Longquan Quan, Xiaoping Li, Kepin Wang, Liangxue Lai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9abc3946a2d240f685ea0ef9c7de72aa
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spelling	oai:doaj.org-article:9abc3946a2d240f685ea0ef9c7de72aa2021-12-02T16:58:18ZEfficient base editing for multiple genes and loci in pigs using base editors10.1038/s41467-019-10421-82041-1723https://doaj.org/article/9abc3946a2d240f685ea0ef9c7de72aa2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10421-8https://doaj.org/toc/2041-1723Base editors can efficiently produce single nucleotide alterations without requiring a double-strand break. Here the authors show base editing at multiple sites simultaneously in pigs.Jingke XieWeikai GeNan LiQishuai LiuFangbing ChenXiaoyu YangXingyun HuangZhen OuyangQuanjun ZhangYu ZhaoZhaoming LiuShixue GouHan WuChengdan LaiNana FanQin JinHui ShiYanhui LiangTing LanLongquan QuanXiaoping LiKepin WangLiangxue LaiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jingke Xie Weikai Ge Nan Li Qishuai Liu Fangbing Chen Xiaoyu Yang Xingyun Huang Zhen Ouyang Quanjun Zhang Yu Zhao Zhaoming Liu Shixue Gou Han Wu Chengdan Lai Nana Fan Qin Jin Hui Shi Yanhui Liang Ting Lan Longquan Quan Xiaoping Li Kepin Wang Liangxue Lai Efficient base editing for multiple genes and loci in pigs using base editors
description	Base editors can efficiently produce single nucleotide alterations without requiring a double-strand break. Here the authors show base editing at multiple sites simultaneously in pigs.
format	article
author	Jingke Xie Weikai Ge Nan Li Qishuai Liu Fangbing Chen Xiaoyu Yang Xingyun Huang Zhen Ouyang Quanjun Zhang Yu Zhao Zhaoming Liu Shixue Gou Han Wu Chengdan Lai Nana Fan Qin Jin Hui Shi Yanhui Liang Ting Lan Longquan Quan Xiaoping Li Kepin Wang Liangxue Lai
author_facet	Jingke Xie Weikai Ge Nan Li Qishuai Liu Fangbing Chen Xiaoyu Yang Xingyun Huang Zhen Ouyang Quanjun Zhang Yu Zhao Zhaoming Liu Shixue Gou Han Wu Chengdan Lai Nana Fan Qin Jin Hui Shi Yanhui Liang Ting Lan Longquan Quan Xiaoping Li Kepin Wang Liangxue Lai
author_sort	Jingke Xie
title	Efficient base editing for multiple genes and loci in pigs using base editors
title_short	Efficient base editing for multiple genes and loci in pigs using base editors
title_full	Efficient base editing for multiple genes and loci in pigs using base editors
title_fullStr	Efficient base editing for multiple genes and loci in pigs using base editors
title_full_unstemmed	Efficient base editing for multiple genes and loci in pigs using base editors
title_sort	efficient base editing for multiple genes and loci in pigs using base editors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9abc3946a2d240f685ea0ef9c7de72aa
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Efficient base editing for multiple genes and loci in pigs using base editors

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