Levels of the TNF-Related Cytokine LIGHT Increase in Hospitalized COVID-19 Patients with Cytokine Release Syndrome and ARDS

ABSTRACT Many coronavirus disease 2019 (COVID-19) patients demonstrate lethal respiratory complications caused by cytokine release syndrome (CRS). Multiple cytokines have been implicated in CRS, but levels of tumor necrosis factor superfamily 14 (TNFSF14) (LIGHT) have not been previously measured in...

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Autores principales:	David S. Perlin, Inbal Zafir-Lavie, Lori Roadcap, Shane Raines, Carl F. Ware, Garry A. Neil
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	ARDS COVID-19 LIGHT TNFSF14 cytokine storm MAb Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/9abd3b910f8b4207827f00c82918bf54
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spelling	oai:doaj.org-article:9abd3b910f8b4207827f00c82918bf542021-11-15T15:30:51ZLevels of the TNF-Related Cytokine LIGHT Increase in Hospitalized COVID-19 Patients with Cytokine Release Syndrome and ARDS10.1128/mSphere.00699-202379-5042https://doaj.org/article/9abd3b910f8b4207827f00c82918bf542020-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00699-20https://doaj.org/toc/2379-5042ABSTRACT Many coronavirus disease 2019 (COVID-19) patients demonstrate lethal respiratory complications caused by cytokine release syndrome (CRS). Multiple cytokines have been implicated in CRS, but levels of tumor necrosis factor superfamily 14 (TNFSF14) (LIGHT) have not been previously measured in this setting. In this study, we observed significantly elevated serum LIGHT levels in hospitalized COVID-19 patients compared to healthy age- and gender-matched control patients. The assay detected bioavailable LIGHT unbound to the inhibitor Decoy receptor-3 (DcR3). Bioavailable LIGHT levels were elevated in patients both on and off ventilatory support, with a trend toward higher levels in patients requiring mechanical ventilation. In hospitalized patients over the age of 60, who exhibited a mortality rate of 82%, LIGHT levels were significantly higher (P = 0.0209) in those who died than in survivors. As previously reported, interleukin 6 (IL-6) levels were also elevated in these patients, with significantly (P = 0.0076) higher levels observed in patients who died than in survivors, paralleling the LIGHT levels. Although attempts to block IL-6 binding to its receptor have shown limited success in COVID-19 CRS, neutralization of LIGHT may prove to be more effective owing to its more central role in regulating antiviral immune responses. The findings presented here demonstrate that LIGHT is a cytokine which may play an important role in COVID-19 patients presenting with acute respiratory distress syndrome (ARDS) and CRS and suggest that LIGHT neutralization may be beneficial to COVID-19 patients.David S. PerlinInbal Zafir-LavieLori RoadcapShane RainesCarl F. WareGarry A. NeilAmerican Society for MicrobiologyarticleARDSCOVID-19LIGHTTNFSF14cytokine stormMAbMicrobiologyQR1-502ENmSphere, Vol 5, Iss 4 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	ARDS COVID-19 LIGHT TNFSF14 cytokine storm MAb Microbiology QR1-502
spellingShingle	ARDS COVID-19 LIGHT TNFSF14 cytokine storm MAb Microbiology QR1-502 David S. Perlin Inbal Zafir-Lavie Lori Roadcap Shane Raines Carl F. Ware Garry A. Neil Levels of the TNF-Related Cytokine LIGHT Increase in Hospitalized COVID-19 Patients with Cytokine Release Syndrome and ARDS
description	ABSTRACT Many coronavirus disease 2019 (COVID-19) patients demonstrate lethal respiratory complications caused by cytokine release syndrome (CRS). Multiple cytokines have been implicated in CRS, but levels of tumor necrosis factor superfamily 14 (TNFSF14) (LIGHT) have not been previously measured in this setting. In this study, we observed significantly elevated serum LIGHT levels in hospitalized COVID-19 patients compared to healthy age- and gender-matched control patients. The assay detected bioavailable LIGHT unbound to the inhibitor Decoy receptor-3 (DcR3). Bioavailable LIGHT levels were elevated in patients both on and off ventilatory support, with a trend toward higher levels in patients requiring mechanical ventilation. In hospitalized patients over the age of 60, who exhibited a mortality rate of 82%, LIGHT levels were significantly higher (P = 0.0209) in those who died than in survivors. As previously reported, interleukin 6 (IL-6) levels were also elevated in these patients, with significantly (P = 0.0076) higher levels observed in patients who died than in survivors, paralleling the LIGHT levels. Although attempts to block IL-6 binding to its receptor have shown limited success in COVID-19 CRS, neutralization of LIGHT may prove to be more effective owing to its more central role in regulating antiviral immune responses. The findings presented here demonstrate that LIGHT is a cytokine which may play an important role in COVID-19 patients presenting with acute respiratory distress syndrome (ARDS) and CRS and suggest that LIGHT neutralization may be beneficial to COVID-19 patients.
format	article
author	David S. Perlin Inbal Zafir-Lavie Lori Roadcap Shane Raines Carl F. Ware Garry A. Neil
author_facet	David S. Perlin Inbal Zafir-Lavie Lori Roadcap Shane Raines Carl F. Ware Garry A. Neil
author_sort	David S. Perlin
title	Levels of the TNF-Related Cytokine LIGHT Increase in Hospitalized COVID-19 Patients with Cytokine Release Syndrome and ARDS
title_short	Levels of the TNF-Related Cytokine LIGHT Increase in Hospitalized COVID-19 Patients with Cytokine Release Syndrome and ARDS
title_full	Levels of the TNF-Related Cytokine LIGHT Increase in Hospitalized COVID-19 Patients with Cytokine Release Syndrome and ARDS
title_fullStr	Levels of the TNF-Related Cytokine LIGHT Increase in Hospitalized COVID-19 Patients with Cytokine Release Syndrome and ARDS
title_full_unstemmed	Levels of the TNF-Related Cytokine LIGHT Increase in Hospitalized COVID-19 Patients with Cytokine Release Syndrome and ARDS
title_sort	levels of the tnf-related cytokine light increase in hospitalized covid-19 patients with cytokine release syndrome and ards
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/9abd3b910f8b4207827f00c82918bf54
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Levels of the TNF-Related Cytokine LIGHT Increase in Hospitalized COVID-19 Patients with Cytokine Release Syndrome and ARDS

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