Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody

Persistent expression of high-risk human papillomavirus (HPV) E6 and E7 is an obligate driver for several human malignancies, including cervical cancer, wherein HPV16 and HPV18 are the most common types. PD-1 antibody immunotherapy helps a subset of cervical cancer patients, and its efficacy might...

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Autores principales:	Shiwen Peng, Louise Ferrall, Stephanie Gaillard, Chenguang Wang, Wei-Yu Chi, Chuan-Hsiang Huang, Richard B. S. Roden, T.-C. Wu, Yung-Nien Chang, Chien-Fu Hung
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/9abd4ea3569c43c292f799ec3bf49263
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spelling	oai:doaj.org-article:9abd4ea3569c43c292f799ec3bf492632021-11-03T18:15:37ZDevelopment of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody2161-21292150-751110.1128/mBio.03224-20https://doaj.org/article/9abd4ea3569c43c292f799ec3bf492632021-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.03224-20https://doaj.org/toc/2161-2129https://doaj.org/toc/2150-7511 Persistent expression of high-risk human papillomavirus (HPV) E6 and E7 is an obligate driver for several human malignancies, including cervical cancer, wherein HPV16 and HPV18 are the most common types. PD-1 antibody immunotherapy helps a subset of cervical cancer patients, and its efficacy might be improved by combination with active vaccination against E6 and/or E7.Shiwen PengLouise FerrallStephanie GaillardChenguang WangWei-Yu ChiChuan-Hsiang HuangRichard B. S. RodenT.-C. WuYung-Nien ChangChien-Fu HungAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Shiwen Peng Louise Ferrall Stephanie Gaillard Chenguang Wang Wei-Yu Chi Chuan-Hsiang Huang Richard B. S. Roden T.-C. Wu Yung-Nien Chang Chien-Fu Hung Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody
description	Persistent expression of high-risk human papillomavirus (HPV) E6 and E7 is an obligate driver for several human malignancies, including cervical cancer, wherein HPV16 and HPV18 are the most common types. PD-1 antibody immunotherapy helps a subset of cervical cancer patients, and its efficacy might be improved by combination with active vaccination against E6 and/or E7.
format	article
author	Shiwen Peng Louise Ferrall Stephanie Gaillard Chenguang Wang Wei-Yu Chi Chuan-Hsiang Huang Richard B. S. Roden T.-C. Wu Yung-Nien Chang Chien-Fu Hung
author_facet	Shiwen Peng Louise Ferrall Stephanie Gaillard Chenguang Wang Wei-Yu Chi Chuan-Hsiang Huang Richard B. S. Roden T.-C. Wu Yung-Nien Chang Chien-Fu Hung
author_sort	Shiwen Peng
title	Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody
title_short	Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody
title_full	Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody
title_fullStr	Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody
title_full_unstemmed	Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody
title_sort	development of dna vaccine targeting e6 and e7 proteins of human papillomavirus 16 (hpv16) and hpv18 for immunotherapy in combination with recombinant vaccinia boost and pd-1 antibody
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/9abd4ea3569c43c292f799ec3bf49263
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Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody

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