Circular RNA Mitochondrial Translation Optimization 1 homologue (CircMTO1) induced by Zinc Finger Protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / Alpha Thalassemia/Mental Retardation, X-linked (ATRX) axis

Oral squamous cell carcinoma (OSCC) is one of the most common cancer types of head and neck cancer, accounting for 95% of all cases. However, the mechanisms underlying the pathogenesis of OSCC remain unclear. Circular RNA (CircRNA) has been extensively studied in the past decades and is a promising...

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Autores principales:	Chen Zou, Xia Li, Xiaozhi Lv, Siyuan Wu, Jing Song, Zhe Tang, Hailing Luo, Haigang Wei, Yilong Ai
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	circular rna circmto1 mir-320a atrx znf460 oral squamous cell carcinoma Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/9ac14b69174943968496c301a8aeb824
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spelling	oai:doaj.org-article:9ac14b69174943968496c301a8aeb8242021-11-11T14:23:43ZCircular RNA Mitochondrial Translation Optimization 1 homologue (CircMTO1) induced by Zinc Finger Protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / Alpha Thalassemia/Mental Retardation, X-linked (ATRX) axis2165-59792165-598710.1080/21655979.2021.1997699https://doaj.org/article/9ac14b69174943968496c301a8aeb8242021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1997699https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Oral squamous cell carcinoma (OSCC) is one of the most common cancer types of head and neck cancer, accounting for 95% of all cases. However, the mechanisms underlying the pathogenesis of OSCC remain unclear. Circular RNA (CircRNA) has been extensively studied in the past decades and is a promising direction for the development of OSCC therapeutic targets. In this study, we aimed to investigate the role of circMTO1 in OSCC progression. First, we validated the characterization and expression of circMTO1 in OSCC. It was found that circMTO1 was upregulated in OSCC tumor tissues and cells. Subsequently, we conducted biological experiments. It was found that circMTO1 knockdown inhibited OSCC cell proliferation, migration, and invasion. Furthermore, we conducted a series of experiments to elucidate the underlying mechanisms. A novel circMTO1/miR-320a/ATRX axis was identified. Our results suggest that circMTO1 modulates ATRX expression to accelerate OSCC progression by sponging miR-320a. Moreover, we found that circMTO1 expression in OSCC was transcriptionally regulated by Zinc Finger Protein 460 (ZNF460). Our study showed a novel ZNF460/circMTO1/miR-320a/ATRX signaling in OSCC development.Chen ZouXia LiXiaozhi LvSiyuan WuJing SongZhe TangHailing LuoHaigang WeiYilong AiTaylor & Francis Grouparticlecircular rnacircmto1mir-320aatrxznf460oral squamous cell carcinomaBiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circular rna circmto1 mir-320a atrx znf460 oral squamous cell carcinoma Biotechnology TP248.13-248.65
spellingShingle	circular rna circmto1 mir-320a atrx znf460 oral squamous cell carcinoma Biotechnology TP248.13-248.65 Chen Zou Xia Li Xiaozhi Lv Siyuan Wu Jing Song Zhe Tang Hailing Luo Haigang Wei Yilong Ai Circular RNA Mitochondrial Translation Optimization 1 homologue (CircMTO1) induced by Zinc Finger Protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / Alpha Thalassemia/Mental Retardation, X-linked (ATRX) axis
description	Oral squamous cell carcinoma (OSCC) is one of the most common cancer types of head and neck cancer, accounting for 95% of all cases. However, the mechanisms underlying the pathogenesis of OSCC remain unclear. Circular RNA (CircRNA) has been extensively studied in the past decades and is a promising direction for the development of OSCC therapeutic targets. In this study, we aimed to investigate the role of circMTO1 in OSCC progression. First, we validated the characterization and expression of circMTO1 in OSCC. It was found that circMTO1 was upregulated in OSCC tumor tissues and cells. Subsequently, we conducted biological experiments. It was found that circMTO1 knockdown inhibited OSCC cell proliferation, migration, and invasion. Furthermore, we conducted a series of experiments to elucidate the underlying mechanisms. A novel circMTO1/miR-320a/ATRX axis was identified. Our results suggest that circMTO1 modulates ATRX expression to accelerate OSCC progression by sponging miR-320a. Moreover, we found that circMTO1 expression in OSCC was transcriptionally regulated by Zinc Finger Protein 460 (ZNF460). Our study showed a novel ZNF460/circMTO1/miR-320a/ATRX signaling in OSCC development.
format	article
author	Chen Zou Xia Li Xiaozhi Lv Siyuan Wu Jing Song Zhe Tang Hailing Luo Haigang Wei Yilong Ai
author_facet	Chen Zou Xia Li Xiaozhi Lv Siyuan Wu Jing Song Zhe Tang Hailing Luo Haigang Wei Yilong Ai
author_sort	Chen Zou
title	Circular RNA Mitochondrial Translation Optimization 1 homologue (CircMTO1) induced by Zinc Finger Protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / Alpha Thalassemia/Mental Retardation, X-linked (ATRX) axis
title_short	Circular RNA Mitochondrial Translation Optimization 1 homologue (CircMTO1) induced by Zinc Finger Protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / Alpha Thalassemia/Mental Retardation, X-linked (ATRX) axis
title_full	Circular RNA Mitochondrial Translation Optimization 1 homologue (CircMTO1) induced by Zinc Finger Protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / Alpha Thalassemia/Mental Retardation, X-linked (ATRX) axis
title_fullStr	Circular RNA Mitochondrial Translation Optimization 1 homologue (CircMTO1) induced by Zinc Finger Protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / Alpha Thalassemia/Mental Retardation, X-linked (ATRX) axis
title_full_unstemmed	Circular RNA Mitochondrial Translation Optimization 1 homologue (CircMTO1) induced by Zinc Finger Protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / Alpha Thalassemia/Mental Retardation, X-linked (ATRX) axis
title_sort	circular rna mitochondrial translation optimization 1 homologue (circmto1) induced by zinc finger protein 460 (znf460) promotes oral squamous cell carcinoma progression through the microrna mir-320a / alpha thalassemia/mental retardation, x-linked (atrx) axis
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/9ac14b69174943968496c301a8aeb824
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Circular RNA Mitochondrial Translation Optimization 1 homologue (CircMTO1) induced by Zinc Finger Protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / Alpha Thalassemia/Mental Retardation, X-linked (ATRX) axis

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