Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity

Pancreatic ductal adenocarcinoma may be initiated by acinar metaplasia, but the molecular and cellular insights during this transition are unclear. Here the authors show, using single cell RNA-sequencing analyses, that mouse metaplastic acinar cells can be clustered into six cell types or states tha...

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Autores principales:	Yehuda Schlesinger, Oshri Yosefov-Levi, Dror Kolodkin-Gal, Roy Zvi Granit, Luriano Peters, Rachel Kalifa, Lei Xia, Abdelmajeed Nasereddin, Idit Shiff, Osher Amran, Yuval Nevo, Sharona Elgavish, Karine Atlan, Gideon Zamir, Oren Parnas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9ac32cd2b6ea40c9ae2b5bb608e74f22
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spelling	oai:doaj.org-article:9ac32cd2b6ea40c9ae2b5bb608e74f222021-12-02T17:19:41ZSingle-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity10.1038/s41467-020-18207-z2041-1723https://doaj.org/article/9ac32cd2b6ea40c9ae2b5bb608e74f222020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18207-zhttps://doaj.org/toc/2041-1723Pancreatic ductal adenocarcinoma may be initiated by acinar metaplasia, but the molecular and cellular insights during this transition are unclear. Here the authors show, using single cell RNA-sequencing analyses, that mouse metaplastic acinar cells can be clustered into six cell types or states that are heterogeneous and have unique transcription programs.Yehuda SchlesingerOshri Yosefov-LeviDror Kolodkin-GalRoy Zvi GranitLuriano PetersRachel KalifaLei XiaAbdelmajeed NasereddinIdit ShiffOsher AmranYuval NevoSharona ElgavishKarine AtlanGideon ZamirOren ParnasNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yehuda Schlesinger Oshri Yosefov-Levi Dror Kolodkin-Gal Roy Zvi Granit Luriano Peters Rachel Kalifa Lei Xia Abdelmajeed Nasereddin Idit Shiff Osher Amran Yuval Nevo Sharona Elgavish Karine Atlan Gideon Zamir Oren Parnas Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity
description	Pancreatic ductal adenocarcinoma may be initiated by acinar metaplasia, but the molecular and cellular insights during this transition are unclear. Here the authors show, using single cell RNA-sequencing analyses, that mouse metaplastic acinar cells can be clustered into six cell types or states that are heterogeneous and have unique transcription programs.
format	article
author	Yehuda Schlesinger Oshri Yosefov-Levi Dror Kolodkin-Gal Roy Zvi Granit Luriano Peters Rachel Kalifa Lei Xia Abdelmajeed Nasereddin Idit Shiff Osher Amran Yuval Nevo Sharona Elgavish Karine Atlan Gideon Zamir Oren Parnas
author_facet	Yehuda Schlesinger Oshri Yosefov-Levi Dror Kolodkin-Gal Roy Zvi Granit Luriano Peters Rachel Kalifa Lei Xia Abdelmajeed Nasereddin Idit Shiff Osher Amran Yuval Nevo Sharona Elgavish Karine Atlan Gideon Zamir Oren Parnas
author_sort	Yehuda Schlesinger
title	Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity
title_short	Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity
title_full	Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity
title_fullStr	Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity
title_full_unstemmed	Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity
title_sort	single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9ac32cd2b6ea40c9ae2b5bb608e74f22
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Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity

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