Multistructure index characterization of heart rate and systolic blood pressure reveals precursory signs of syncope

Abstract Recurrent syncope — abrupt loss of consciousness — can have a serious impact on patients’ quality of life, comparable with chronic illnesses. Vasovagal syncope (VVS) is a specific reflex syncope, in which an inappropriate reaction of the autonomic nervous system (ANS) plays a key role in th...

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Autores principales:	Danuta Makowiec, Beata Graff, Zbigniew R. Struzik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9ac72375c6684bbb95ee6918493a1753
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spelling	oai:doaj.org-article:9ac72375c6684bbb95ee6918493a17532021-12-02T15:05:46ZMultistructure index characterization of heart rate and systolic blood pressure reveals precursory signs of syncope10.1038/s41598-017-00354-x2045-2322https://doaj.org/article/9ac72375c6684bbb95ee6918493a17532017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00354-xhttps://doaj.org/toc/2045-2322Abstract Recurrent syncope — abrupt loss of consciousness — can have a serious impact on patients’ quality of life, comparable with chronic illnesses. Vasovagal syncope (VVS) is a specific reflex syncope, in which an inappropriate reaction of the autonomic nervous system (ANS) plays a key role in the pathophysiology. In syncope diagnosis, an ideal diagnostic method should positively identify vasovagal sensitive patients, without the need to perform a specialised head-up tilt table (HUTT) test. We apply a novel methodology of multistructure index (MI) statistics for seamlessly evaluating the size spectrum of the asymmetry properties of magnitudes of neural reflexes responsible for maintaining the homeostatic dynamics of autonomic control. Simultaneous evaluation using the MI of the effects on heart rate and blood pressure involved in achieving homeostasis of contrasting properties of the dynamics of slow and fast neural regulation reveals a clear distinction between vasovagal patients and healthy subjects, who are/are not susceptible to spontaneous fainting. Remarkably, a healthy cardiovascular response to the HUTT test is indeed evident prior to the test, making the MI a robust novel indicator, clearly distinguishing the cardiovascular autonomic regulation of healthy people from that of vasovagal patients without the need to perform an actual HUTT test.Danuta MakowiecBeata GraffZbigniew R. StruzikNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Danuta Makowiec Beata Graff Zbigniew R. Struzik Multistructure index characterization of heart rate and systolic blood pressure reveals precursory signs of syncope
description	Abstract Recurrent syncope — abrupt loss of consciousness — can have a serious impact on patients’ quality of life, comparable with chronic illnesses. Vasovagal syncope (VVS) is a specific reflex syncope, in which an inappropriate reaction of the autonomic nervous system (ANS) plays a key role in the pathophysiology. In syncope diagnosis, an ideal diagnostic method should positively identify vasovagal sensitive patients, without the need to perform a specialised head-up tilt table (HUTT) test. We apply a novel methodology of multistructure index (MI) statistics for seamlessly evaluating the size spectrum of the asymmetry properties of magnitudes of neural reflexes responsible for maintaining the homeostatic dynamics of autonomic control. Simultaneous evaluation using the MI of the effects on heart rate and blood pressure involved in achieving homeostasis of contrasting properties of the dynamics of slow and fast neural regulation reveals a clear distinction between vasovagal patients and healthy subjects, who are/are not susceptible to spontaneous fainting. Remarkably, a healthy cardiovascular response to the HUTT test is indeed evident prior to the test, making the MI a robust novel indicator, clearly distinguishing the cardiovascular autonomic regulation of healthy people from that of vasovagal patients without the need to perform an actual HUTT test.
format	article
author	Danuta Makowiec Beata Graff Zbigniew R. Struzik
author_facet	Danuta Makowiec Beata Graff Zbigniew R. Struzik
author_sort	Danuta Makowiec
title	Multistructure index characterization of heart rate and systolic blood pressure reveals precursory signs of syncope
title_short	Multistructure index characterization of heart rate and systolic blood pressure reveals precursory signs of syncope
title_full	Multistructure index characterization of heart rate and systolic blood pressure reveals precursory signs of syncope
title_fullStr	Multistructure index characterization of heart rate and systolic blood pressure reveals precursory signs of syncope
title_full_unstemmed	Multistructure index characterization of heart rate and systolic blood pressure reveals precursory signs of syncope
title_sort	multistructure index characterization of heart rate and systolic blood pressure reveals precursory signs of syncope
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9ac72375c6684bbb95ee6918493a1753
work_keys_str_mv	AT danutamakowiec multistructureindexcharacterizationofheartrateandsystolicbloodpressurerevealsprecursorysignsofsyncope AT beatagraff multistructureindexcharacterizationofheartrateandsystolicbloodpressurerevealsprecursorysignsofsyncope AT zbigniewrstruzik multistructureindexcharacterizationofheartrateandsystolicbloodpressurerevealsprecursorysignsofsyncope
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Multistructure index characterization of heart rate and systolic blood pressure reveals precursory signs of syncope

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