Direct measurement of vagal tone in rats does not show correlation to HRV

Abstract The vagus nerve is the largest autonomic nerve, innervating nearly every organ in the body. “Vagal tone” is a clinical measure believed to indicate overall levels of vagal activity, but is measured indirectly through the heart rate variability (HRV). Abnormal HRV has been associated with ma...

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Autores principales:	Joseph T. Marmerstein, Grant A. McCallum, Dominique M. Durand
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9accc90144d24c67b3ab03533cb89fd2
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spelling	oai:doaj.org-article:9accc90144d24c67b3ab03533cb89fd22021-12-02T15:23:01ZDirect measurement of vagal tone in rats does not show correlation to HRV10.1038/s41598-020-79808-82045-2322https://doaj.org/article/9accc90144d24c67b3ab03533cb89fd22021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79808-8https://doaj.org/toc/2045-2322Abstract The vagus nerve is the largest autonomic nerve, innervating nearly every organ in the body. “Vagal tone” is a clinical measure believed to indicate overall levels of vagal activity, but is measured indirectly through the heart rate variability (HRV). Abnormal HRV has been associated with many severe conditions such as diabetes, heart failure, and hypertension. However, vagal tone has never been directly measured, leading to disagreements in its interpretation and influencing the effectiveness of vagal therapies. Using custom carbon nanotube yarn electrodes, we were able to chronically record neural activity from the left cervical vagus in both anesthetized and non-anesthetized rats. Here we show that tonic vagal activity does not correlate with common HRV metrics with or without anesthesia. Although we found that average vagal activity is increased during inspiration compared to expiration, this respiratory-linked signal was not correlated with HRV either. These results represent a clear advance in neural recording technology but also point to the need for a re-interpretation of the link between HRV and “vagal tone”.Joseph T. MarmersteinGrant A. McCallumDominique M. DurandNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joseph T. Marmerstein Grant A. McCallum Dominique M. Durand Direct measurement of vagal tone in rats does not show correlation to HRV
description	Abstract The vagus nerve is the largest autonomic nerve, innervating nearly every organ in the body. “Vagal tone” is a clinical measure believed to indicate overall levels of vagal activity, but is measured indirectly through the heart rate variability (HRV). Abnormal HRV has been associated with many severe conditions such as diabetes, heart failure, and hypertension. However, vagal tone has never been directly measured, leading to disagreements in its interpretation and influencing the effectiveness of vagal therapies. Using custom carbon nanotube yarn electrodes, we were able to chronically record neural activity from the left cervical vagus in both anesthetized and non-anesthetized rats. Here we show that tonic vagal activity does not correlate with common HRV metrics with or without anesthesia. Although we found that average vagal activity is increased during inspiration compared to expiration, this respiratory-linked signal was not correlated with HRV either. These results represent a clear advance in neural recording technology but also point to the need for a re-interpretation of the link between HRV and “vagal tone”.
format	article
author	Joseph T. Marmerstein Grant A. McCallum Dominique M. Durand
author_facet	Joseph T. Marmerstein Grant A. McCallum Dominique M. Durand
author_sort	Joseph T. Marmerstein
title	Direct measurement of vagal tone in rats does not show correlation to HRV
title_short	Direct measurement of vagal tone in rats does not show correlation to HRV
title_full	Direct measurement of vagal tone in rats does not show correlation to HRV
title_fullStr	Direct measurement of vagal tone in rats does not show correlation to HRV
title_full_unstemmed	Direct measurement of vagal tone in rats does not show correlation to HRV
title_sort	direct measurement of vagal tone in rats does not show correlation to hrv
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9accc90144d24c67b3ab03533cb89fd2
work_keys_str_mv	AT josephtmarmerstein directmeasurementofvagaltoneinratsdoesnotshowcorrelationtohrv AT grantamccallum directmeasurementofvagaltoneinratsdoesnotshowcorrelationtohrv AT dominiquemdurand directmeasurementofvagaltoneinratsdoesnotshowcorrelationtohrv
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Direct measurement of vagal tone in rats does not show correlation to HRV

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