Temperature and species-dependent regulation of browning in retrobulbar fat

Abstract Retrobulbar fat deposits surround the posterior retina and optic nerve head, but their function and origin are obscure. We report that mouse retrobulbar fat is a neural crest-derived tissue histologically and transcriptionally resembles interscapular brown fat. In contrast, human retrobulba...

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Autores principales:	Fatemeh Rajaii, Dong Won Kim, Jianbo Pan, Nicholas R. Mahoney, Charles G. Eberhart, Jiang Qian, Seth Blackshaw
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9ad9e3cc221347d2b58de83d24e63a4a
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spelling	oai:doaj.org-article:9ad9e3cc221347d2b58de83d24e63a4a2021-12-02T14:06:31ZTemperature and species-dependent regulation of browning in retrobulbar fat10.1038/s41598-021-82672-92045-2322https://doaj.org/article/9ad9e3cc221347d2b58de83d24e63a4a2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82672-9https://doaj.org/toc/2045-2322Abstract Retrobulbar fat deposits surround the posterior retina and optic nerve head, but their function and origin are obscure. We report that mouse retrobulbar fat is a neural crest-derived tissue histologically and transcriptionally resembles interscapular brown fat. In contrast, human retrobulbar fat closely resembles white adipose tissue. Retrobulbar fat is also brown in other rodents, which are typically housed at temperatures below thermoneutrality, but is white in larger animals. We show that retrobulbar fat in mice housed at thermoneutral temperature show reduced expression of the brown fat marker Ucp1, and histological properties intermediate between white and brown fat. We conclude that retrobulbar fat can potentially serve as a site of active thermogenesis, that this capability is both temperature and species-dependent, and that this may facilitate regulation of intraocular temperature.Fatemeh RajaiiDong Won KimJianbo PanNicholas R. MahoneyCharles G. EberhartJiang QianSeth BlackshawNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fatemeh Rajaii Dong Won Kim Jianbo Pan Nicholas R. Mahoney Charles G. Eberhart Jiang Qian Seth Blackshaw Temperature and species-dependent regulation of browning in retrobulbar fat
description	Abstract Retrobulbar fat deposits surround the posterior retina and optic nerve head, but their function and origin are obscure. We report that mouse retrobulbar fat is a neural crest-derived tissue histologically and transcriptionally resembles interscapular brown fat. In contrast, human retrobulbar fat closely resembles white adipose tissue. Retrobulbar fat is also brown in other rodents, which are typically housed at temperatures below thermoneutrality, but is white in larger animals. We show that retrobulbar fat in mice housed at thermoneutral temperature show reduced expression of the brown fat marker Ucp1, and histological properties intermediate between white and brown fat. We conclude that retrobulbar fat can potentially serve as a site of active thermogenesis, that this capability is both temperature and species-dependent, and that this may facilitate regulation of intraocular temperature.
format	article
author	Fatemeh Rajaii Dong Won Kim Jianbo Pan Nicholas R. Mahoney Charles G. Eberhart Jiang Qian Seth Blackshaw
author_facet	Fatemeh Rajaii Dong Won Kim Jianbo Pan Nicholas R. Mahoney Charles G. Eberhart Jiang Qian Seth Blackshaw
author_sort	Fatemeh Rajaii
title	Temperature and species-dependent regulation of browning in retrobulbar fat
title_short	Temperature and species-dependent regulation of browning in retrobulbar fat
title_full	Temperature and species-dependent regulation of browning in retrobulbar fat
title_fullStr	Temperature and species-dependent regulation of browning in retrobulbar fat
title_full_unstemmed	Temperature and species-dependent regulation of browning in retrobulbar fat
title_sort	temperature and species-dependent regulation of browning in retrobulbar fat
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9ad9e3cc221347d2b58de83d24e63a4a
work_keys_str_mv	AT fatemehrajaii temperatureandspeciesdependentregulationofbrowninginretrobulbarfat AT dongwonkim temperatureandspeciesdependentregulationofbrowninginretrobulbarfat AT jianbopan temperatureandspeciesdependentregulationofbrowninginretrobulbarfat AT nicholasrmahoney temperatureandspeciesdependentregulationofbrowninginretrobulbarfat AT charlesgeberhart temperatureandspeciesdependentregulationofbrowninginretrobulbarfat AT jiangqian temperatureandspeciesdependentregulationofbrowninginretrobulbarfat AT sethblackshaw temperatureandspeciesdependentregulationofbrowninginretrobulbarfat
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Temperature and species-dependent regulation of browning in retrobulbar fat

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