Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR

IRE1 and PERK, both important mediators of the unfold protein response pathway, are differentially regulated during plasma cell differentiation. Here the authors show that an ufmylation target, Ufbp1, suppresses PERK to stimulate plasma cell development and is induced by the IRE1/XBP1 pathway to pro...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Huabin Zhu, Brinda Bhatt, Sathish Sivaprakasam, Yafei Cai, Siyang Liu, Sai Karthik Kodeboyina, Nikhil Patel, Natasha M. Savage, Ashok Sharma, Randal J. Kaufman, Honglin Li, Nagendra Singh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9adc16d000c24247b9a8853f22437942
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9adc16d000c24247b9a8853f22437942
record_format	dspace
spelling	oai:doaj.org-article:9adc16d000c24247b9a8853f224379422021-12-02T14:40:17ZUfbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR10.1038/s41467-019-08908-52041-1723https://doaj.org/article/9adc16d000c24247b9a8853f224379422019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08908-5https://doaj.org/toc/2041-1723IRE1 and PERK, both important mediators of the unfold protein response pathway, are differentially regulated during plasma cell differentiation. Here the authors show that an ufmylation target, Ufbp1, suppresses PERK to stimulate plasma cell development and is induced by the IRE1/XBP1 pathway to promote ER expansion .Huabin ZhuBrinda BhattSathish SivaprakasamYafei CaiSiyang LiuSai Karthik KodeboyinaNikhil PatelNatasha M. SavageAshok SharmaRandal J. KaufmanHonglin LiNagendra SinghNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huabin Zhu Brinda Bhatt Sathish Sivaprakasam Yafei Cai Siyang Liu Sai Karthik Kodeboyina Nikhil Patel Natasha M. Savage Ashok Sharma Randal J. Kaufman Honglin Li Nagendra Singh Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR
description	IRE1 and PERK, both important mediators of the unfold protein response pathway, are differentially regulated during plasma cell differentiation. Here the authors show that an ufmylation target, Ufbp1, suppresses PERK to stimulate plasma cell development and is induced by the IRE1/XBP1 pathway to promote ER expansion .
format	article
author	Huabin Zhu Brinda Bhatt Sathish Sivaprakasam Yafei Cai Siyang Liu Sai Karthik Kodeboyina Nikhil Patel Natasha M. Savage Ashok Sharma Randal J. Kaufman Honglin Li Nagendra Singh
author_facet	Huabin Zhu Brinda Bhatt Sathish Sivaprakasam Yafei Cai Siyang Liu Sai Karthik Kodeboyina Nikhil Patel Natasha M. Savage Ashok Sharma Randal J. Kaufman Honglin Li Nagendra Singh
author_sort	Huabin Zhu
title	Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR
title_short	Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR
title_full	Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR
title_fullStr	Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR
title_full_unstemmed	Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR
title_sort	ufbp1 promotes plasma cell development and er expansion by modulating distinct branches of upr
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9adc16d000c24247b9a8853f22437942
work_keys_str_mv	AT huabinzhu ufbp1promotesplasmacelldevelopmentanderexpansionbymodulatingdistinctbranchesofupr AT brindabhatt ufbp1promotesplasmacelldevelopmentanderexpansionbymodulatingdistinctbranchesofupr AT sathishsivaprakasam ufbp1promotesplasmacelldevelopmentanderexpansionbymodulatingdistinctbranchesofupr AT yafeicai ufbp1promotesplasmacelldevelopmentanderexpansionbymodulatingdistinctbranchesofupr AT siyangliu ufbp1promotesplasmacelldevelopmentanderexpansionbymodulatingdistinctbranchesofupr AT saikarthikkodeboyina ufbp1promotesplasmacelldevelopmentanderexpansionbymodulatingdistinctbranchesofupr AT nikhilpatel ufbp1promotesplasmacelldevelopmentanderexpansionbymodulatingdistinctbranchesofupr AT natashamsavage ufbp1promotesplasmacelldevelopmentanderexpansionbymodulatingdistinctbranchesofupr AT ashoksharma ufbp1promotesplasmacelldevelopmentanderexpansionbymodulatingdistinctbranchesofupr AT randaljkaufman ufbp1promotesplasmacelldevelopmentanderexpansionbymodulatingdistinctbranchesofupr AT honglinli ufbp1promotesplasmacelldevelopmentanderexpansionbymodulatingdistinctbranchesofupr AT nagendrasingh ufbp1promotesplasmacelldevelopmentanderexpansionbymodulatingdistinctbranchesofupr
_version_	1718390371387441152

Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR

Ejemplares similares