Sumoylation regulates the assembly and activity of the SMN complex

Sumoylation is important for the assembly and function of the SMN complex, which plays a central role in RNA processing. Here the authors show that loss of this posttranslational modification impairs the ability of SMN to correct selective deficits in the sensory-motor circuit of animal models of sp...

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Auteurs principaux:	Giulietta M. Riboldi, Irene Faravelli, Takaaki Kuwajima, Nicolas Delestrée, Georgia Dermentzaki, Mariangels De Planell-Saguer, Paola Rinchetti, Le Thi Hao, Christine C. Beattie, Stefania Corti, Serge Przedborski, George Z. Mentis, Francesco Lotti
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/9ae40bf770e34a49910b6f8f9467d2e2
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spelling	oai:doaj.org-article:9ae40bf770e34a49910b6f8f9467d2e22021-12-02T18:01:14ZSumoylation regulates the assembly and activity of the SMN complex10.1038/s41467-021-25272-52041-1723https://doaj.org/article/9ae40bf770e34a49910b6f8f9467d2e22021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25272-5https://doaj.org/toc/2041-1723Sumoylation is important for the assembly and function of the SMN complex, which plays a central role in RNA processing. Here the authors show that loss of this posttranslational modification impairs the ability of SMN to correct selective deficits in the sensory-motor circuit of animal models of spinal muscular atrophy.Giulietta M. RiboldiIrene FaravelliTakaaki KuwajimaNicolas DelestréeGeorgia DermentzakiMariangels De Planell-SaguerPaola RinchettiLe Thi HaoChristine C. BeattieStefania CortiSerge PrzedborskiGeorge Z. MentisFrancesco LottiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giulietta M. Riboldi Irene Faravelli Takaaki Kuwajima Nicolas Delestrée Georgia Dermentzaki Mariangels De Planell-Saguer Paola Rinchetti Le Thi Hao Christine C. Beattie Stefania Corti Serge Przedborski George Z. Mentis Francesco Lotti Sumoylation regulates the assembly and activity of the SMN complex
description	Sumoylation is important for the assembly and function of the SMN complex, which plays a central role in RNA processing. Here the authors show that loss of this posttranslational modification impairs the ability of SMN to correct selective deficits in the sensory-motor circuit of animal models of spinal muscular atrophy.
format	article
author	Giulietta M. Riboldi Irene Faravelli Takaaki Kuwajima Nicolas Delestrée Georgia Dermentzaki Mariangels De Planell-Saguer Paola Rinchetti Le Thi Hao Christine C. Beattie Stefania Corti Serge Przedborski George Z. Mentis Francesco Lotti
author_facet	Giulietta M. Riboldi Irene Faravelli Takaaki Kuwajima Nicolas Delestrée Georgia Dermentzaki Mariangels De Planell-Saguer Paola Rinchetti Le Thi Hao Christine C. Beattie Stefania Corti Serge Przedborski George Z. Mentis Francesco Lotti
author_sort	Giulietta M. Riboldi
title	Sumoylation regulates the assembly and activity of the SMN complex
title_short	Sumoylation regulates the assembly and activity of the SMN complex
title_full	Sumoylation regulates the assembly and activity of the SMN complex
title_fullStr	Sumoylation regulates the assembly and activity of the SMN complex
title_full_unstemmed	Sumoylation regulates the assembly and activity of the SMN complex
title_sort	sumoylation regulates the assembly and activity of the smn complex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9ae40bf770e34a49910b6f8f9467d2e2
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Sumoylation regulates the assembly and activity of the SMN complex

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