The effect of cognitive training on the brain’s local connectivity organization in healthy older adults

Abstract Cognitive training has been shown effective in improving the cognitive function of older adults. While training related plasticity of the brain has been observed at different levels, it is still open to exploration whether local functional connectivity (FC) may be affected by training. Here...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lifu Deng, Yan Cheng, Xinyi Cao, Wei Feng, Hong Zhu, Lijuan Jiang, Wenyuan Wu, Shanbao Tong, Junfeng Sun, Chunbo Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9aebc217f157476a8d1d003256e53a76
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9aebc217f157476a8d1d003256e53a76
record_format	dspace
spelling	oai:doaj.org-article:9aebc217f157476a8d1d003256e53a762021-12-02T15:10:02ZThe effect of cognitive training on the brain’s local connectivity organization in healthy older adults10.1038/s41598-019-45463-x2045-2322https://doaj.org/article/9aebc217f157476a8d1d003256e53a762019-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-45463-xhttps://doaj.org/toc/2045-2322Abstract Cognitive training has been shown effective in improving the cognitive function of older adults. While training related plasticity of the brain has been observed at different levels, it is still open to exploration whether local functional connectivity (FC) may be affected by training. Here, we examined the neuroimaging data from a previous randomized-controlled double-blinded behavioural study, in which healthy older adults participated in a 3-month cognitive training program. Resting-state fMRI was acquired at baseline and one year after training. The local FC in the brain was estimated using the regional homogeneity (ReHo), and the high ReHo clusters (HRCs) were extracted to quantify the level of local FC integration. Results showed that: (i) HRCs exhibited a power-law size distribution; (ii) local FC were less integrated in older participants than in younger participants; (iii) local FC in older participants of the training group became more integrated after training than the control group; (iv) the baseline local FC integration was positively correlated with educational level. These results indicated a training-related alteration in local FC.Lifu DengYan ChengXinyi CaoWei FengHong ZhuLijuan JiangWenyuan WuShanbao TongJunfeng SunChunbo LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lifu Deng Yan Cheng Xinyi Cao Wei Feng Hong Zhu Lijuan Jiang Wenyuan Wu Shanbao Tong Junfeng Sun Chunbo Li The effect of cognitive training on the brain’s local connectivity organization in healthy older adults
description	Abstract Cognitive training has been shown effective in improving the cognitive function of older adults. While training related plasticity of the brain has been observed at different levels, it is still open to exploration whether local functional connectivity (FC) may be affected by training. Here, we examined the neuroimaging data from a previous randomized-controlled double-blinded behavioural study, in which healthy older adults participated in a 3-month cognitive training program. Resting-state fMRI was acquired at baseline and one year after training. The local FC in the brain was estimated using the regional homogeneity (ReHo), and the high ReHo clusters (HRCs) were extracted to quantify the level of local FC integration. Results showed that: (i) HRCs exhibited a power-law size distribution; (ii) local FC were less integrated in older participants than in younger participants; (iii) local FC in older participants of the training group became more integrated after training than the control group; (iv) the baseline local FC integration was positively correlated with educational level. These results indicated a training-related alteration in local FC.
format	article
author	Lifu Deng Yan Cheng Xinyi Cao Wei Feng Hong Zhu Lijuan Jiang Wenyuan Wu Shanbao Tong Junfeng Sun Chunbo Li
author_facet	Lifu Deng Yan Cheng Xinyi Cao Wei Feng Hong Zhu Lijuan Jiang Wenyuan Wu Shanbao Tong Junfeng Sun Chunbo Li
author_sort	Lifu Deng
title	The effect of cognitive training on the brain’s local connectivity organization in healthy older adults
title_short	The effect of cognitive training on the brain’s local connectivity organization in healthy older adults
title_full	The effect of cognitive training on the brain’s local connectivity organization in healthy older adults
title_fullStr	The effect of cognitive training on the brain’s local connectivity organization in healthy older adults
title_full_unstemmed	The effect of cognitive training on the brain’s local connectivity organization in healthy older adults
title_sort	effect of cognitive training on the brain’s local connectivity organization in healthy older adults
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9aebc217f157476a8d1d003256e53a76
work_keys_str_mv	AT lifudeng theeffectofcognitivetrainingonthebrainslocalconnectivityorganizationinhealthyolderadults AT yancheng theeffectofcognitivetrainingonthebrainslocalconnectivityorganizationinhealthyolderadults AT xinyicao theeffectofcognitivetrainingonthebrainslocalconnectivityorganizationinhealthyolderadults AT weifeng theeffectofcognitivetrainingonthebrainslocalconnectivityorganizationinhealthyolderadults AT hongzhu theeffectofcognitivetrainingonthebrainslocalconnectivityorganizationinhealthyolderadults AT lijuanjiang theeffectofcognitivetrainingonthebrainslocalconnectivityorganizationinhealthyolderadults AT wenyuanwu theeffectofcognitivetrainingonthebrainslocalconnectivityorganizationinhealthyolderadults AT shanbaotong theeffectofcognitivetrainingonthebrainslocalconnectivityorganizationinhealthyolderadults AT junfengsun theeffectofcognitivetrainingonthebrainslocalconnectivityorganizationinhealthyolderadults AT chunboli theeffectofcognitivetrainingonthebrainslocalconnectivityorganizationinhealthyolderadults AT lifudeng effectofcognitivetrainingonthebrainslocalconnectivityorganizationinhealthyolderadults AT yancheng effectofcognitivetrainingonthebrainslocalconnectivityorganizationinhealthyolderadults AT xinyicao effectofcognitivetrainingonthebrainslocalconnectivityorganizationinhealthyolderadults AT weifeng effectofcognitivetrainingonthebrainslocalconnectivityorganizationinhealthyolderadults AT hongzhu effectofcognitivetrainingonthebrainslocalconnectivityorganizationinhealthyolderadults AT lijuanjiang effectofcognitivetrainingonthebrainslocalconnectivityorganizationinhealthyolderadults AT wenyuanwu effectofcognitivetrainingonthebrainslocalconnectivityorganizationinhealthyolderadults AT shanbaotong effectofcognitivetrainingonthebrainslocalconnectivityorganizationinhealthyolderadults AT junfengsun effectofcognitivetrainingonthebrainslocalconnectivityorganizationinhealthyolderadults AT chunboli effectofcognitivetrainingonthebrainslocalconnectivityorganizationinhealthyolderadults
_version_	1718387768069980160

The effect of cognitive training on the brain’s local connectivity organization in healthy older adults

Ejemplares similares