Profile of inhaled levodopa and its potential in the treatment of Parkinson’s disease: evidence to date
Ami B Patel, Joohi Jimenez-Shahed Department of Neurology, Baylor College of Medicine, Houston, TX, USA Abstract: Inhaled levodopa is a newly emerging therapeutic option in the treatment of “off” symptoms associated with Parkinson’s disease (PD). Its mode of...
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Dove Medical Press
2018
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oai:doaj.org-article:9aebef3e7e3e4cf0ab7f3e16661e4c132021-12-02T03:08:04ZProfile of inhaled levodopa and its potential in the treatment of Parkinson’s disease: evidence to date1178-2021https://doaj.org/article/9aebef3e7e3e4cf0ab7f3e16661e4c132018-11-01T00:00:00Zhttps://www.dovepress.com/profile-of-inhaled-levodopa-and-its-potential-in-the-treatment-of-park-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Ami B Patel, Joohi Jimenez-Shahed Department of Neurology, Baylor College of Medicine, Houston, TX, USA Abstract: Inhaled levodopa is a newly emerging therapeutic option in the treatment of “off” symptoms associated with Parkinson’s disease (PD). Its mode of delivery offers more rapid absorption of levodopa and shorter onset of clinical benefit compared to oral formulations, and has been shown to be feasible for use in patients with PD experiencing worse motor function due to declining plasma levodopa levels. Clinical development of this compound is supported by preclinical, Phase I–III, long-term-safety studies and studies in special populations, including otherwise-healthy asthmatics and smokers. These investigations demonstrated that the drug is well tolerated without risk of long-term (up to 1 year) changes in pulmonary function or spirometry measures. The most common side effects among PD patients were a mild cough, upper respiratory tract infection, nausea, sputum discoloration, and dyskinesia. Inhaled levodopa offers a different administration method and side-effect profile from the currently available options for rescue therapy for Off periods in PD, though comparative studies have not been performed. The drug is presently under review by the US Food and Drug Administration. Keywords: levodopa, dry-powder inhalation, motor fluctuations, dyskinesia, spirometry Patel ABJimenez-Shahed JDove Medical Pressarticlelevodopadry powder inhalationmotor fluctuationsdyskinesiaspirometryNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2955-2964 (2018) |
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EN |
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levodopa dry powder inhalation motor fluctuations dyskinesia spirometry Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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levodopa dry powder inhalation motor fluctuations dyskinesia spirometry Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Patel AB Jimenez-Shahed J Profile of inhaled levodopa and its potential in the treatment of Parkinson’s disease: evidence to date |
| description |
Ami B Patel, Joohi Jimenez-Shahed Department of Neurology, Baylor College of Medicine, Houston, TX, USA Abstract: Inhaled levodopa is a newly emerging therapeutic option in the treatment of “off” symptoms associated with Parkinson’s disease (PD). Its mode of delivery offers more rapid absorption of levodopa and shorter onset of clinical benefit compared to oral formulations, and has been shown to be feasible for use in patients with PD experiencing worse motor function due to declining plasma levodopa levels. Clinical development of this compound is supported by preclinical, Phase I–III, long-term-safety studies and studies in special populations, including otherwise-healthy asthmatics and smokers. These investigations demonstrated that the drug is well tolerated without risk of long-term (up to 1 year) changes in pulmonary function or spirometry measures. The most common side effects among PD patients were a mild cough, upper respiratory tract infection, nausea, sputum discoloration, and dyskinesia. Inhaled levodopa offers a different administration method and side-effect profile from the currently available options for rescue therapy for Off periods in PD, though comparative studies have not been performed. The drug is presently under review by the US Food and Drug Administration. Keywords: levodopa, dry-powder inhalation, motor fluctuations, dyskinesia, spirometry |
| format |
article |
| author |
Patel AB Jimenez-Shahed J |
| author_facet |
Patel AB Jimenez-Shahed J |
| author_sort |
Patel AB |
| title |
Profile of inhaled levodopa and its potential in the treatment of Parkinson’s disease: evidence to date |
| title_short |
Profile of inhaled levodopa and its potential in the treatment of Parkinson’s disease: evidence to date |
| title_full |
Profile of inhaled levodopa and its potential in the treatment of Parkinson’s disease: evidence to date |
| title_fullStr |
Profile of inhaled levodopa and its potential in the treatment of Parkinson’s disease: evidence to date |
| title_full_unstemmed |
Profile of inhaled levodopa and its potential in the treatment of Parkinson’s disease: evidence to date |
| title_sort |
profile of inhaled levodopa and its potential in the treatment of parkinson’s disease: evidence to date |
| publisher |
Dove Medical Press |
| publishDate |
2018 |
| url |
https://doaj.org/article/9aebef3e7e3e4cf0ab7f3e16661e4c13 |
| work_keys_str_mv |
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