Candida markers of urogenital biotopes diseases: reactivity to lectins of probiotics

Possibilities of using eukaryotic microorganisms (Candida spp.) of microbiocenoses of mucosal open cavities as potential biomarkers of pathological states of biotopes were investigated. To identify biotopes characterizing Candida strains we used new promising natural glycoconjugate recognition agent...

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Autores principales:	M. V. Lakhtin, V. M. Lakhtin, S. S. Afanasiev, A. L. Bayrakova, V. A. Aleshkin, M. S. Afanasiev
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	probiotic lectins lactobacilli bifidus bacteria microbiocenoses pathogens candida urogenital tract mucosal immunity diseases cerivicitis Science Q
Acceso en línea:	https://doaj.org/article/9aec0166ede34696888d8b56769c2aa5
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spelling	oai:doaj.org-article:9aec0166ede34696888d8b56769c2aa52021-11-23T06:14:39ZCandida markers of urogenital biotopes diseases: reactivity to lectins of probiotics2541-94202587-959610.29413/ABS.2018-3.1.7https://doaj.org/article/9aec0166ede34696888d8b56769c2aa52018-02-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/536https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Possibilities of using eukaryotic microorganisms (Candida spp.) of microbiocenoses of mucosal open cavities as potential biomarkers of pathological states of biotopes were investigated. To identify biotopes characterizing Candida strains we used new promising natural glycoconjugate recognition agents -lectins that imitate the effect of probiotics. The lectins were isolated from cultures of probiotic strains of lactobacillus and bifidus bacteria characterizing and supporting probiotic compartment of microbiocenosis of human mucosal open cavities as part of endogen sensory system "lectins of probiotic microorganisms - opportunistic eukaryotic yeast-like fungi". The study was carried out on examples of cases of dysbiotic disorders in the composition of microbiocenoses against the background of pathologies of the urogenital tract of patients with established diagnosis. Results demonstrate the early (before development of visible inflammatory reactions) presence of changed Candida cells in pathological biotopes of urogenital tract indicating states of diseases characterizing with increased differentiating affinities and sensitivities of Candida to a panel of probiotic lectins. Probiotic lectins are perspective in combinative prognostics and diagnostics of pathological states of functional biotopes of human mucosal open cavities as well as for prophylaxis and therapy of such states by compensation of deficit or absence of probiotic microflora to support healthy balance of mucosal immunity, instead of probiotics or in combinations with probiotics, antibiotics and other antimicrobial agents, therapeutics, and factors. The data also perspective in study of pathological biotope states possessing risk of conversion into tumor-like landscapes.M. V. LakhtinV. M. LakhtinS. S. AfanasievA. L. BayrakovaV. A. AleshkinM. S. AfanasievScientific Сentre for Family Health and Human Reproduction Problemsarticleprobiotic lectinslactobacillibifidus bacteriamicrobiocenosespathogenscandidaurogenital tractmucosal immunitydiseasescerivicitisScienceQRUActa Biomedica Scientifica, Vol 3, Iss 1, Pp 49-53 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	probiotic lectins lactobacilli bifidus bacteria microbiocenoses pathogens candida urogenital tract mucosal immunity diseases cerivicitis Science Q
spellingShingle	probiotic lectins lactobacilli bifidus bacteria microbiocenoses pathogens candida urogenital tract mucosal immunity diseases cerivicitis Science Q M. V. Lakhtin V. M. Lakhtin S. S. Afanasiev A. L. Bayrakova V. A. Aleshkin M. S. Afanasiev Candida markers of urogenital biotopes diseases: reactivity to lectins of probiotics
description	Possibilities of using eukaryotic microorganisms (Candida spp.) of microbiocenoses of mucosal open cavities as potential biomarkers of pathological states of biotopes were investigated. To identify biotopes characterizing Candida strains we used new promising natural glycoconjugate recognition agents -lectins that imitate the effect of probiotics. The lectins were isolated from cultures of probiotic strains of lactobacillus and bifidus bacteria characterizing and supporting probiotic compartment of microbiocenosis of human mucosal open cavities as part of endogen sensory system "lectins of probiotic microorganisms - opportunistic eukaryotic yeast-like fungi". The study was carried out on examples of cases of dysbiotic disorders in the composition of microbiocenoses against the background of pathologies of the urogenital tract of patients with established diagnosis. Results demonstrate the early (before development of visible inflammatory reactions) presence of changed Candida cells in pathological biotopes of urogenital tract indicating states of diseases characterizing with increased differentiating affinities and sensitivities of Candida to a panel of probiotic lectins. Probiotic lectins are perspective in combinative prognostics and diagnostics of pathological states of functional biotopes of human mucosal open cavities as well as for prophylaxis and therapy of such states by compensation of deficit or absence of probiotic microflora to support healthy balance of mucosal immunity, instead of probiotics or in combinations with probiotics, antibiotics and other antimicrobial agents, therapeutics, and factors. The data also perspective in study of pathological biotope states possessing risk of conversion into tumor-like landscapes.
format	article
author	M. V. Lakhtin V. M. Lakhtin S. S. Afanasiev A. L. Bayrakova V. A. Aleshkin M. S. Afanasiev
author_facet	M. V. Lakhtin V. M. Lakhtin S. S. Afanasiev A. L. Bayrakova V. A. Aleshkin M. S. Afanasiev
author_sort	M. V. Lakhtin
title	Candida markers of urogenital biotopes diseases: reactivity to lectins of probiotics
title_short	Candida markers of urogenital biotopes diseases: reactivity to lectins of probiotics
title_full	Candida markers of urogenital biotopes diseases: reactivity to lectins of probiotics
title_fullStr	Candida markers of urogenital biotopes diseases: reactivity to lectins of probiotics
title_full_unstemmed	Candida markers of urogenital biotopes diseases: reactivity to lectins of probiotics
title_sort	candida markers of urogenital biotopes diseases: reactivity to lectins of probiotics
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/9aec0166ede34696888d8b56769c2aa5
work_keys_str_mv	AT mvlakhtin candidamarkersofurogenitalbiotopesdiseasesreactivitytolectinsofprobiotics AT vmlakhtin candidamarkersofurogenitalbiotopesdiseasesreactivitytolectinsofprobiotics AT ssafanasiev candidamarkersofurogenitalbiotopesdiseasesreactivitytolectinsofprobiotics AT albayrakova candidamarkersofurogenitalbiotopesdiseasesreactivitytolectinsofprobiotics AT vaaleshkin candidamarkersofurogenitalbiotopesdiseasesreactivitytolectinsofprobiotics AT msafanasiev candidamarkersofurogenitalbiotopesdiseasesreactivitytolectinsofprobiotics
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Candida markers of urogenital biotopes diseases: reactivity to lectins of probiotics

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