Flaxseed oil supplementation manipulates correlations between serum individual mol % free fatty acid levels and insulin resistance in type 2 diabetics. Insulin resistance and percent remaining pancreatic β-cell function are unaffected

Objectives. Elevated total serum free fatty acids (FFAs) concentrations have been suggested, controversially, to enhance insulin resistance and decrease percent remaining β-cell function. However, concentrations of individual serum FFAs have never been published in terms of their relationship (corre...

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Autores principales:	Barre DE, Mizier-Barre KA, Griscti O, Hafez K
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	insulin resistance pancreatic β-cell function free fatty acids alpha-linolenic acid flaxseed oil type 2 diabetes Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/9af0e544391e45cdb803cd2ca34ad11a
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spelling	oai:doaj.org-article:9af0e544391e45cdb803cd2ca34ad11a2021-12-02T15:29:47ZFlaxseed oil supplementation manipulates correlations between serum individual mol % free fatty acid levels and insulin resistance in type 2 diabetics. Insulin resistance and percent remaining pancreatic β-cell function are unaffected1336-032910.1515/enr-2016-0020https://doaj.org/article/9af0e544391e45cdb803cd2ca34ad11a2016-10-01T00:00:00Zhttps://doi.org/10.1515/enr-2016-0020https://doaj.org/toc/1336-0329Objectives. Elevated total serum free fatty acids (FFAs) concentrations have been suggested, controversially, to enhance insulin resistance and decrease percent remaining β-cell function. However, concentrations of individual serum FFAs have never been published in terms of their relationship (correlation) to homeostatic model assessment-insulin resistance (HOMA-IR) and percent remaining β-cell function (HOMA-%β) in the type 2 diabetics (T2Ds). Alpha-linolenic acid consumption has a negative correlation with the insulin resistance, which in turn is negatively correlated with the remaining β-cell function. The primary objective was to test the hypothesis that there would be different relationship (correlation) between the blood serum individual free FFA mol % levels and HOMA-IR and/or HOMA-%β in T2D. The secondary objective was to test the hypothesis that flaxseed oil, previously being shown to be ineffective in the glycemic control in T2Ds, may alter these correlations in a statistically significant manner as well as HOMA-IR and/or HOMA-%β.Barre DEMizier-Barre KAGriscti OHafez KSciendoarticleinsulin resistancepancreatic β-cell functionfree fatty acidsalpha-linolenic acidflaxseed oiltype 2 diabetesDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 50, Iss 4, Pp 183-193 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	insulin resistance pancreatic β-cell function free fatty acids alpha-linolenic acid flaxseed oil type 2 diabetes Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	insulin resistance pancreatic β-cell function free fatty acids alpha-linolenic acid flaxseed oil type 2 diabetes Diseases of the endocrine glands. Clinical endocrinology RC648-665 Barre DE Mizier-Barre KA Griscti O Hafez K Flaxseed oil supplementation manipulates correlations between serum individual mol % free fatty acid levels and insulin resistance in type 2 diabetics. Insulin resistance and percent remaining pancreatic β-cell function are unaffected
description	Objectives. Elevated total serum free fatty acids (FFAs) concentrations have been suggested, controversially, to enhance insulin resistance and decrease percent remaining β-cell function. However, concentrations of individual serum FFAs have never been published in terms of their relationship (correlation) to homeostatic model assessment-insulin resistance (HOMA-IR) and percent remaining β-cell function (HOMA-%β) in the type 2 diabetics (T2Ds). Alpha-linolenic acid consumption has a negative correlation with the insulin resistance, which in turn is negatively correlated with the remaining β-cell function. The primary objective was to test the hypothesis that there would be different relationship (correlation) between the blood serum individual free FFA mol % levels and HOMA-IR and/or HOMA-%β in T2D. The secondary objective was to test the hypothesis that flaxseed oil, previously being shown to be ineffective in the glycemic control in T2Ds, may alter these correlations in a statistically significant manner as well as HOMA-IR and/or HOMA-%β.
format	article
author	Barre DE Mizier-Barre KA Griscti O Hafez K
author_facet	Barre DE Mizier-Barre KA Griscti O Hafez K
author_sort	Barre DE
title	Flaxseed oil supplementation manipulates correlations between serum individual mol % free fatty acid levels and insulin resistance in type 2 diabetics. Insulin resistance and percent remaining pancreatic β-cell function are unaffected
title_short	Flaxseed oil supplementation manipulates correlations between serum individual mol % free fatty acid levels and insulin resistance in type 2 diabetics. Insulin resistance and percent remaining pancreatic β-cell function are unaffected
title_full	Flaxseed oil supplementation manipulates correlations between serum individual mol % free fatty acid levels and insulin resistance in type 2 diabetics. Insulin resistance and percent remaining pancreatic β-cell function are unaffected
title_fullStr	Flaxseed oil supplementation manipulates correlations between serum individual mol % free fatty acid levels and insulin resistance in type 2 diabetics. Insulin resistance and percent remaining pancreatic β-cell function are unaffected
title_full_unstemmed	Flaxseed oil supplementation manipulates correlations between serum individual mol % free fatty acid levels and insulin resistance in type 2 diabetics. Insulin resistance and percent remaining pancreatic β-cell function are unaffected
title_sort	flaxseed oil supplementation manipulates correlations between serum individual mol % free fatty acid levels and insulin resistance in type 2 diabetics. insulin resistance and percent remaining pancreatic β-cell function are unaffected
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/9af0e544391e45cdb803cd2ca34ad11a
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Flaxseed oil supplementation manipulates correlations between serum individual mol % free fatty acid levels and insulin resistance in type 2 diabetics. Insulin resistance and percent remaining pancreatic β-cell function are unaffected

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