Sex differences in psychotropic and analgesic drug use before and after initiating treatment with acetylcholinesterase inhibitors.

<h4>Background/aims</h4>The aim was to explore the impact of sex on prevalence, patterns and trends in the prescription of psychotropics and analgesics in users of acetylcholinesterase inhibitors (AChEIs), before and after AChEI initiation, compared to the general population.<h4>Me...

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Autores principales:	Anne Sverdrup Efjestad, Hege Ihle-Hansen, Vidar Hjellvik, Knut Engedal, Hege Salvesen Blix
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9af92f80a97e4b8e980f92f0dd475662
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spelling	oai:doaj.org-article:9af92f80a97e4b8e980f92f0dd4756622021-12-02T20:06:13ZSex differences in psychotropic and analgesic drug use before and after initiating treatment with acetylcholinesterase inhibitors.1932-620310.1371/journal.pone.0243804https://doaj.org/article/9af92f80a97e4b8e980f92f0dd4756622021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0243804https://doaj.org/toc/1932-6203<h4>Background/aims</h4>The aim was to explore the impact of sex on prevalence, patterns and trends in the prescription of psychotropics and analgesics in users of acetylcholinesterase inhibitors (AChEIs), before and after AChEI initiation, compared to the general population.<h4>Methods</h4>A prospective study applying data from the Norwegian Prescription Database (NorPD) in the period 2004-2016. Prescription of antidepressants, antipsychotics, analgesics including opioids, benzodiazepines and z-hypnotics in persistent AChEI users was studied in a follow-up period from four years before to two years after AChEI initiation in men and women of four age groups: 37-64, 65-72, 73-80 and 81-88 years.<h4>Results</h4>Use of antidepressants, antipsychotics and weaker analgesics increased in both sexes during the follow-up period in 11.764 persistent AChEI users. Women with pre-dementia and dementia stages of AD showed a prescription pattern with more use of psychotropics and opioids than men, except for antipsychotics.<h4>Conclusion</h4>Female sex showed to have a significant influence on the prescriptions of psychotropics and analgesics in AD patients in a pre-dementia and dementia stage. The exception is for antipsychotics, that men used more than women. The prescription pattern showed a higher extent of polypharmacy of psychotropics and/or opioids in women than in men. The total prescription pattern of analgesics could indicate an undertreatment of pain in pre-dementia and dementia stages, most pronounced in men.Anne Sverdrup EfjestadHege Ihle-HansenVidar HjellvikKnut EngedalHege Salvesen BlixPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0243804 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anne Sverdrup Efjestad Hege Ihle-Hansen Vidar Hjellvik Knut Engedal Hege Salvesen Blix Sex differences in psychotropic and analgesic drug use before and after initiating treatment with acetylcholinesterase inhibitors.
description	<h4>Background/aims</h4>The aim was to explore the impact of sex on prevalence, patterns and trends in the prescription of psychotropics and analgesics in users of acetylcholinesterase inhibitors (AChEIs), before and after AChEI initiation, compared to the general population.<h4>Methods</h4>A prospective study applying data from the Norwegian Prescription Database (NorPD) in the period 2004-2016. Prescription of antidepressants, antipsychotics, analgesics including opioids, benzodiazepines and z-hypnotics in persistent AChEI users was studied in a follow-up period from four years before to two years after AChEI initiation in men and women of four age groups: 37-64, 65-72, 73-80 and 81-88 years.<h4>Results</h4>Use of antidepressants, antipsychotics and weaker analgesics increased in both sexes during the follow-up period in 11.764 persistent AChEI users. Women with pre-dementia and dementia stages of AD showed a prescription pattern with more use of psychotropics and opioids than men, except for antipsychotics.<h4>Conclusion</h4>Female sex showed to have a significant influence on the prescriptions of psychotropics and analgesics in AD patients in a pre-dementia and dementia stage. The exception is for antipsychotics, that men used more than women. The prescription pattern showed a higher extent of polypharmacy of psychotropics and/or opioids in women than in men. The total prescription pattern of analgesics could indicate an undertreatment of pain in pre-dementia and dementia stages, most pronounced in men.
format	article
author	Anne Sverdrup Efjestad Hege Ihle-Hansen Vidar Hjellvik Knut Engedal Hege Salvesen Blix
author_facet	Anne Sverdrup Efjestad Hege Ihle-Hansen Vidar Hjellvik Knut Engedal Hege Salvesen Blix
author_sort	Anne Sverdrup Efjestad
title	Sex differences in psychotropic and analgesic drug use before and after initiating treatment with acetylcholinesterase inhibitors.
title_short	Sex differences in psychotropic and analgesic drug use before and after initiating treatment with acetylcholinesterase inhibitors.
title_full	Sex differences in psychotropic and analgesic drug use before and after initiating treatment with acetylcholinesterase inhibitors.
title_fullStr	Sex differences in psychotropic and analgesic drug use before and after initiating treatment with acetylcholinesterase inhibitors.
title_full_unstemmed	Sex differences in psychotropic and analgesic drug use before and after initiating treatment with acetylcholinesterase inhibitors.
title_sort	sex differences in psychotropic and analgesic drug use before and after initiating treatment with acetylcholinesterase inhibitors.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9af92f80a97e4b8e980f92f0dd475662
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Sex differences in psychotropic and analgesic drug use before and after initiating treatment with acetylcholinesterase inhibitors.

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