Structural dynamics in proteins induced by and probed with X-ray free-electron laser pulses

Structural dynamics in proteins induced by and probed with X-ray free-electron laser pulses

The local X-ray-induced dynamics that occur in protein crystals during serial femtosecond crystallography (SFX) measurements at XFELs are not well understood. Here the authors performed a time-resolved X-ray pump X-ray probe SFX experiment, and they observe distinct structural changes in the disulfi...

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Autores principales: Karol Nass, Alexander Gorel, Malik M. Abdullah, Andrew V. Martin, Marco Kloos, Agostino Marinelli, Andrew Aquila, Thomas R. M. Barends, Franz-Josef Decker, R. Bruce Doak, Lutz Foucar, Elisabeth Hartmann, Mario Hilpert, Mark S. Hunter, Zoltan Jurek, Jason E. Koglin, Alexander Kozlov, Alberto A. Lutman, Gabriela Nass Kovacs, Christopher M. Roome, Robert L. Shoeman, Robin Santra, Harry M. Quiney, Beata Ziaja, Sébastien Boutet, Ilme Schlichting
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Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/9afb811b5338411fb4f4557becfc7546
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spelling oai:doaj.org-article:9afb811b5338411fb4f4557becfc75462021-12-02T16:50:02ZStructural dynamics in proteins induced by and probed with X-ray free-electron laser pulses10.1038/s41467-020-15610-42041-1723https://doaj.org/article/9afb811b5338411fb4f4557becfc75462020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15610-4https://doaj.org/toc/2041-1723The local X-ray-induced dynamics that occur in protein crystals during serial femtosecond crystallography (SFX) measurements at XFELs are not well understood. Here the authors performed a time-resolved X-ray pump X-ray probe SFX experiment, and they observe distinct structural changes in the disulfide bridges and peptide backbone of proteins; complementing theoretical approaches allow them to further characterize the details of the X-ray induced ionization and local structural dynamics.Karol NassAlexander GorelMalik M. AbdullahAndrew V. MartinMarco KloosAgostino MarinelliAndrew AquilaThomas R. M. BarendsFranz-Josef DeckerR. Bruce DoakLutz FoucarElisabeth HartmannMario HilpertMark S. HunterZoltan JurekJason E. KoglinAlexander KozlovAlberto A. LutmanGabriela Nass KovacsChristopher M. RoomeRobert L. ShoemanRobin SantraHarry M. QuineyBeata ZiajaSébastien BoutetIlme SchlichtingNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Karol Nass
Alexander Gorel
Malik M. Abdullah
Andrew V. Martin
Marco Kloos
Agostino Marinelli
Andrew Aquila
Thomas R. M. Barends
Franz-Josef Decker
R. Bruce Doak
Lutz Foucar
Elisabeth Hartmann
Mario Hilpert
Mark S. Hunter
Zoltan Jurek
Jason E. Koglin
Alexander Kozlov
Alberto A. Lutman
Gabriela Nass Kovacs
Christopher M. Roome
Robert L. Shoeman
Robin Santra
Harry M. Quiney
Beata Ziaja
Sébastien Boutet
Ilme Schlichting
Structural dynamics in proteins induced by and probed with X-ray free-electron laser pulses
description The local X-ray-induced dynamics that occur in protein crystals during serial femtosecond crystallography (SFX) measurements at XFELs are not well understood. Here the authors performed a time-resolved X-ray pump X-ray probe SFX experiment, and they observe distinct structural changes in the disulfide bridges and peptide backbone of proteins; complementing theoretical approaches allow them to further characterize the details of the X-ray induced ionization and local structural dynamics.
format article
author Karol Nass
Alexander Gorel
Malik M. Abdullah
Andrew V. Martin
Marco Kloos
Agostino Marinelli
Andrew Aquila
Thomas R. M. Barends
Franz-Josef Decker
R. Bruce Doak
Lutz Foucar
Elisabeth Hartmann
Mario Hilpert
Mark S. Hunter
Zoltan Jurek
Jason E. Koglin
Alexander Kozlov
Alberto A. Lutman
Gabriela Nass Kovacs
Christopher M. Roome
Robert L. Shoeman
Robin Santra
Harry M. Quiney
Beata Ziaja
Sébastien Boutet
Ilme Schlichting
author_facet Karol Nass
Alexander Gorel
Malik M. Abdullah
Andrew V. Martin
Marco Kloos
Agostino Marinelli
Andrew Aquila
Thomas R. M. Barends
Franz-Josef Decker
R. Bruce Doak
Lutz Foucar
Elisabeth Hartmann
Mario Hilpert
Mark S. Hunter
Zoltan Jurek
Jason E. Koglin
Alexander Kozlov
Alberto A. Lutman
Gabriela Nass Kovacs
Christopher M. Roome
Robert L. Shoeman
Robin Santra
Harry M. Quiney
Beata Ziaja
Sébastien Boutet
Ilme Schlichting
author_sort Karol Nass
title Structural dynamics in proteins induced by and probed with X-ray free-electron laser pulses
title_short Structural dynamics in proteins induced by and probed with X-ray free-electron laser pulses
title_full Structural dynamics in proteins induced by and probed with X-ray free-electron laser pulses
title_fullStr Structural dynamics in proteins induced by and probed with X-ray free-electron laser pulses
title_full_unstemmed Structural dynamics in proteins induced by and probed with X-ray free-electron laser pulses
title_sort structural dynamics in proteins induced by and probed with x-ray free-electron laser pulses
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/9afb811b5338411fb4f4557becfc7546
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