Bioactive Compounds from Kefir and Their Potential Benefits on Health: A Systematic Review and Meta-Analysis

Despite evidence of health benefits from kefir administration, a systematic review with meta-analysis on bioactive compounds associated with these benefits is still absent in the literature. Kefir is fermented milk resulting from the metabolism of a complex microbiota in symbiosis. Recent researches...

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Autores principales:	Carla P. Vieira, Anisio Iuri L. S. Rosario, Carini A. Lelis, Bruna Samara S. Rekowsky, Anna Paula A. Carvalho, Denes Kaic A. Rosário, Thaísa A. Elias, Marion P. Costa, Debora Foguel, Carlos A. Conte-Junior
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/9aff969768a041388fb24f5920c2ed6e
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spelling	oai:doaj.org-article:9aff969768a041388fb24f5920c2ed6e2021-11-08T02:36:14ZBioactive Compounds from Kefir and Their Potential Benefits on Health: A Systematic Review and Meta-Analysis1942-099410.1155/2021/9081738https://doaj.org/article/9aff969768a041388fb24f5920c2ed6e2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/9081738https://doaj.org/toc/1942-0994Despite evidence of health benefits from kefir administration, a systematic review with meta-analysis on bioactive compounds associated with these benefits is still absent in the literature. Kefir is fermented milk resulting from the metabolism of a complex microbiota in symbiosis. Recent researches have investigated the bioactive compounds responsible for the preventive and therapeutic effects attributed to kefir. However, differences in functional potential between industrial and artisanal kefir are still controversial. Firstly, we identified differences in the microbial composition among both types of kefir. Available evidence concerning the action of different bioactive compounds from kefir on health, both from in vitro and in vivo studies, was subsequently summarized to draw a primary conclusion of the dose and the intervention time for effect, the producer microorganisms, the precursor in the milk, and the action mechanism. Meta-analysis was performed to investigate the statistically significant differences (P<0.05) between intervention and control and between both types of kefir for each health effect studied. In summary, the bioactive compounds more commonly reported were exopolysaccharides, including kefiran, bioactive peptides, and organic acids, especially lactic acid. Kefir bioactive compounds presented antimicrobial, anticancer, and immune-modulatory activities corroborated by the meta-analysis. However, clinical evidence is urgently needed to strengthen the practical applicability of these bioactive compounds. The mechanisms of their action were diverse, indicating that they can act by different signaling pathways. Still, industrial and artisanal kefir may differ regarding functional potential—OR of 8.56 (95% CI: 2.27–32.21, P≤.001)—according to the observed health effect, which can be associated with differences in the microbial composition between both types of kefir.Carla P. VieiraAnisio Iuri L. S. RosarioCarini A. LelisBruna Samara S. RekowskyAnna Paula A. CarvalhoDenes Kaic A. RosárioThaísa A. EliasMarion P. CostaDebora FoguelCarlos A. Conte-JuniorHindawi LimitedarticleCytologyQH573-671ENOxidative Medicine and Cellular Longevity, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Carla P. Vieira Anisio Iuri L. S. Rosario Carini A. Lelis Bruna Samara S. Rekowsky Anna Paula A. Carvalho Denes Kaic A. Rosário Thaísa A. Elias Marion P. Costa Debora Foguel Carlos A. Conte-Junior Bioactive Compounds from Kefir and Their Potential Benefits on Health: A Systematic Review and Meta-Analysis
description	Despite evidence of health benefits from kefir administration, a systematic review with meta-analysis on bioactive compounds associated with these benefits is still absent in the literature. Kefir is fermented milk resulting from the metabolism of a complex microbiota in symbiosis. Recent researches have investigated the bioactive compounds responsible for the preventive and therapeutic effects attributed to kefir. However, differences in functional potential between industrial and artisanal kefir are still controversial. Firstly, we identified differences in the microbial composition among both types of kefir. Available evidence concerning the action of different bioactive compounds from kefir on health, both from in vitro and in vivo studies, was subsequently summarized to draw a primary conclusion of the dose and the intervention time for effect, the producer microorganisms, the precursor in the milk, and the action mechanism. Meta-analysis was performed to investigate the statistically significant differences (P<0.05) between intervention and control and between both types of kefir for each health effect studied. In summary, the bioactive compounds more commonly reported were exopolysaccharides, including kefiran, bioactive peptides, and organic acids, especially lactic acid. Kefir bioactive compounds presented antimicrobial, anticancer, and immune-modulatory activities corroborated by the meta-analysis. However, clinical evidence is urgently needed to strengthen the practical applicability of these bioactive compounds. The mechanisms of their action were diverse, indicating that they can act by different signaling pathways. Still, industrial and artisanal kefir may differ regarding functional potential—OR of 8.56 (95% CI: 2.27–32.21, P≤.001)—according to the observed health effect, which can be associated with differences in the microbial composition between both types of kefir.
format	article
author	Carla P. Vieira Anisio Iuri L. S. Rosario Carini A. Lelis Bruna Samara S. Rekowsky Anna Paula A. Carvalho Denes Kaic A. Rosário Thaísa A. Elias Marion P. Costa Debora Foguel Carlos A. Conte-Junior
author_facet	Carla P. Vieira Anisio Iuri L. S. Rosario Carini A. Lelis Bruna Samara S. Rekowsky Anna Paula A. Carvalho Denes Kaic A. Rosário Thaísa A. Elias Marion P. Costa Debora Foguel Carlos A. Conte-Junior
author_sort	Carla P. Vieira
title	Bioactive Compounds from Kefir and Their Potential Benefits on Health: A Systematic Review and Meta-Analysis
title_short	Bioactive Compounds from Kefir and Their Potential Benefits on Health: A Systematic Review and Meta-Analysis
title_full	Bioactive Compounds from Kefir and Their Potential Benefits on Health: A Systematic Review and Meta-Analysis
title_fullStr	Bioactive Compounds from Kefir and Their Potential Benefits on Health: A Systematic Review and Meta-Analysis
title_full_unstemmed	Bioactive Compounds from Kefir and Their Potential Benefits on Health: A Systematic Review and Meta-Analysis
title_sort	bioactive compounds from kefir and their potential benefits on health: a systematic review and meta-analysis
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/9aff969768a041388fb24f5920c2ed6e
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Bioactive Compounds from Kefir and Their Potential Benefits on Health: A Systematic Review and Meta-Analysis

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