Acquired Nisin Resistance in <italic toggle="yes">Staphylococcus aureus</italic> Involves Constitutive Activation of an Intrinsic Peptide Antibiotic Detoxification Module

Acquired Nisin Resistance in <italic toggle="yes">Staphylococcus aureus</italic> Involves Constitutive Activation of an Intrinsic Peptide Antibiotic Detoxification Module

ABSTRACT Resistance to the lantibiotic nisin (NIS) arises readily in Staphylococcus aureus as a consequence of mutations in the nsaS gene, which encodes the sensor kinase of the NsaRS two-component regulatory system. Here we present a series of studies to establish how these mutational changes resul...

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Autores principales: Christopher P. Randall, Arya Gupta, Bret Utley-Drew, Siu Yi Lee, Genevieve Morrison-Williams, Alex J. O’Neill
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
Materias:
bacteriocin
lantibiotic
resistance studies
staphylococci
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/9b03415a9c534106a0f35536e02051d2
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