Current trends in drug treatment of obsessive–compulsive disorder

Eric H Decloedt1, Dan J Stein21Department of Internal Medicine, Division of Clinical Pharmacology, 2Department of Psychiatry, University of Cape Town, South AfricaAbstract: This article aims to highlight current trends in the pharmacologic management of obsessive–compulsive disorder (O...

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Autores principales: Eric H Decloedt, Dan J Stein
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Publicado: Dove Medical Press 2010
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Acceso en línea:https://doaj.org/article/9b03c9fc61234c7088c7aa5b003e831f
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spelling oai:doaj.org-article:9b03c9fc61234c7088c7aa5b003e831f2021-12-02T04:50:55ZCurrent trends in drug treatment of obsessive–compulsive disorder1176-63281178-2021https://doaj.org/article/9b03c9fc61234c7088c7aa5b003e831f2010-05-01T00:00:00Zhttp://www.dovepress.com/current-trends-in-drug-treatment-of-obsessivendashcompulsive-disorder-a4394https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Eric H Decloedt1, Dan J Stein21Department of Internal Medicine, Division of Clinical Pharmacology, 2Department of Psychiatry, University of Cape Town, South AfricaAbstract: This article aims to highlight current trends in the pharmacologic management of obsessive–compulsive disorder (OCD). A systematic search of the electronic database MEDLINE was conducted. The first case report of clomipramine efficacy in the management OCD more than 40 years ago gave new hope for the treatment of this debilitating disorder. Selective serotonin reuptake inhibitors (SSRIs) proved to have a similar efficacy profile compared with clomipramine but had a superior tolerability profile. While many patients with OCD respond to SSRIs or clomipramine, the treatment of those with refractory OCD remains challenging. Different augmentation agents in treatment-resistant OCD have been explored, with antipsychotic agents having the largest supporting evidence base. Nevertheless, new pharmacologic treatment options are required and are under investigation.Keywords: obsessive–compulsive disorder, pharmacology, treatment, drug Eric H DecloedtDan J SteinDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2010, Iss Issue 1, Pp 233-242 (2010)
institution DOAJ
collection DOAJ
language EN
topic Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Eric H Decloedt
Dan J Stein
Current trends in drug treatment of obsessive–compulsive disorder
description Eric H Decloedt1, Dan J Stein21Department of Internal Medicine, Division of Clinical Pharmacology, 2Department of Psychiatry, University of Cape Town, South AfricaAbstract: This article aims to highlight current trends in the pharmacologic management of obsessive–compulsive disorder (OCD). A systematic search of the electronic database MEDLINE was conducted. The first case report of clomipramine efficacy in the management OCD more than 40 years ago gave new hope for the treatment of this debilitating disorder. Selective serotonin reuptake inhibitors (SSRIs) proved to have a similar efficacy profile compared with clomipramine but had a superior tolerability profile. While many patients with OCD respond to SSRIs or clomipramine, the treatment of those with refractory OCD remains challenging. Different augmentation agents in treatment-resistant OCD have been explored, with antipsychotic agents having the largest supporting evidence base. Nevertheless, new pharmacologic treatment options are required and are under investigation.Keywords: obsessive–compulsive disorder, pharmacology, treatment, drug
format article
author Eric H Decloedt
Dan J Stein
author_facet Eric H Decloedt
Dan J Stein
author_sort Eric H Decloedt
title Current trends in drug treatment of obsessive–compulsive disorder
title_short Current trends in drug treatment of obsessive–compulsive disorder
title_full Current trends in drug treatment of obsessive–compulsive disorder
title_fullStr Current trends in drug treatment of obsessive–compulsive disorder
title_full_unstemmed Current trends in drug treatment of obsessive–compulsive disorder
title_sort current trends in drug treatment of obsessive–compulsive disorder
publisher Dove Medical Press
publishDate 2010
url https://doaj.org/article/9b03c9fc61234c7088c7aa5b003e831f
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