Association Between the Circulating Level of 25-Hydroxyvitamin D and Clinical Results After Cardiac Surgery: A Meta-Analysis and Systematic Review

Background: Vitamin D (VitD) is an important pleiotropic hormone for organ systems. Studies have focused on the level of VitD, especially that of 25-hydroxyvitamin D (25-(OH)-VitD), in patients after cardiac surgery and the relationship between VitD deficiency and adverse outcomes, but the results h...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yulin Zhang, Jiawen Li, Yu Qiu, Xue Gong, Yunru He, Peng Yue, Xiaolan Zheng, Lei Liu, Hongyu Liao, Kaiyu Zhou, Yimin Hua, Yifei Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	25-(OH)-VitD cardiac surgery clinical outcomes prognosis meta-analysis Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/9b03dc802de44991aaa0fbfcd1097941
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9b03dc802de44991aaa0fbfcd1097941
record_format	dspace
spelling	oai:doaj.org-article:9b03dc802de44991aaa0fbfcd10979412021-11-15T05:55:26ZAssociation Between the Circulating Level of 25-Hydroxyvitamin D and Clinical Results After Cardiac Surgery: A Meta-Analysis and Systematic Review2297-055X10.3389/fcvm.2021.734504https://doaj.org/article/9b03dc802de44991aaa0fbfcd10979412021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.734504/fullhttps://doaj.org/toc/2297-055XBackground: Vitamin D (VitD) is an important pleiotropic hormone for organ systems. Studies have focused on the level of VitD, especially that of 25-hydroxyvitamin D (25-(OH)-VitD), in patients after cardiac surgery and the relationship between VitD deficiency and adverse outcomes, but the results have been inconsistent. We carried out a meta-analysis to evaluate differences in the 25-(OH)-VitD level before and after cardiac surgery, and evaluated the predictive value of 25-(OH)-VitD level in the clinical outcomes of patients undergoing cardiac surgery.Methods: Studies related to VitD level and cardiac surgery were searched from PubMed, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials databases from inception to October 2020. We applied the Newcastle–Ottawa Scale to assess the risk of a bias in individual studies. We examined the heterogeneity and publication bias and performed subgroup analyses and sensitivity analyses.Results: Fifteen studies were included in our analysis. The 25-(OH)-VitD level was significantly lower immediately after surgery [stand mean difference (SMD), 0.69; 95%CI (0.1, 1.28), P = 0.023] and 24-h after surgery [0.84; (0.47, 1.21), 0.000] compared with that before surgery. A higher prevalence of 25-(OH)-VitD deficiency was recorded 24 h after surgery [RR, 0.59; 95%CI (0.47, 0.73), P = 0.00]. Pooled results demonstrated a significant relationship between the preoperative 25-(OH)-VitD level and vasoactive-inotropic score (VIS) [SMD, −3.71; 95%CI (−6.32, −1.10); P = 0.005], and patients with 25-(OH)-VitD deficiency revealed a comparatively poor prognosis and severe condition after cardiac surgery [−0.80; (−1.41, −0.19), 0.01]. However, 25-(OH)-VitD deficiency was not associated with the duration of stay in the intensive care unit.Conclusions: Cardiac surgery would leads to deficiency of 25-(OH)-VitD. And the preoperative and postoperative levels of 25-(OH)-VitD are associated with adverse events, which is eligible to work as an indicator to demonstrate clinical outcomes.Yulin ZhangJiawen LiYu QiuXue GongYunru HePeng YueXiaolan ZhengLei LiuHongyu LiaoKaiyu ZhouYimin HuaYifei LiFrontiers Media S.A.article25-(OH)-VitDcardiac surgeryclinical outcomesprognosismeta-analysisDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	25-(OH)-VitD cardiac surgery clinical outcomes prognosis meta-analysis Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	25-(OH)-VitD cardiac surgery clinical outcomes prognosis meta-analysis Diseases of the circulatory (Cardiovascular) system RC666-701 Yulin Zhang Jiawen Li Yu Qiu Xue Gong Yunru He Peng Yue Xiaolan Zheng Lei Liu Hongyu Liao Kaiyu Zhou Yimin Hua Yifei Li Association Between the Circulating Level of 25-Hydroxyvitamin D and Clinical Results After Cardiac Surgery: A Meta-Analysis and Systematic Review
description	Background: Vitamin D (VitD) is an important pleiotropic hormone for organ systems. Studies have focused on the level of VitD, especially that of 25-hydroxyvitamin D (25-(OH)-VitD), in patients after cardiac surgery and the relationship between VitD deficiency and adverse outcomes, but the results have been inconsistent. We carried out a meta-analysis to evaluate differences in the 25-(OH)-VitD level before and after cardiac surgery, and evaluated the predictive value of 25-(OH)-VitD level in the clinical outcomes of patients undergoing cardiac surgery.Methods: Studies related to VitD level and cardiac surgery were searched from PubMed, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials databases from inception to October 2020. We applied the Newcastle–Ottawa Scale to assess the risk of a bias in individual studies. We examined the heterogeneity and publication bias and performed subgroup analyses and sensitivity analyses.Results: Fifteen studies were included in our analysis. The 25-(OH)-VitD level was significantly lower immediately after surgery [stand mean difference (SMD), 0.69; 95%CI (0.1, 1.28), P = 0.023] and 24-h after surgery [0.84; (0.47, 1.21), 0.000] compared with that before surgery. A higher prevalence of 25-(OH)-VitD deficiency was recorded 24 h after surgery [RR, 0.59; 95%CI (0.47, 0.73), P = 0.00]. Pooled results demonstrated a significant relationship between the preoperative 25-(OH)-VitD level and vasoactive-inotropic score (VIS) [SMD, −3.71; 95%CI (−6.32, −1.10); P = 0.005], and patients with 25-(OH)-VitD deficiency revealed a comparatively poor prognosis and severe condition after cardiac surgery [−0.80; (−1.41, −0.19), 0.01]. However, 25-(OH)-VitD deficiency was not associated with the duration of stay in the intensive care unit.Conclusions: Cardiac surgery would leads to deficiency of 25-(OH)-VitD. And the preoperative and postoperative levels of 25-(OH)-VitD are associated with adverse events, which is eligible to work as an indicator to demonstrate clinical outcomes.
format	article
author	Yulin Zhang Jiawen Li Yu Qiu Xue Gong Yunru He Peng Yue Xiaolan Zheng Lei Liu Hongyu Liao Kaiyu Zhou Yimin Hua Yifei Li
author_facet	Yulin Zhang Jiawen Li Yu Qiu Xue Gong Yunru He Peng Yue Xiaolan Zheng Lei Liu Hongyu Liao Kaiyu Zhou Yimin Hua Yifei Li
author_sort	Yulin Zhang
title	Association Between the Circulating Level of 25-Hydroxyvitamin D and Clinical Results After Cardiac Surgery: A Meta-Analysis and Systematic Review
title_short	Association Between the Circulating Level of 25-Hydroxyvitamin D and Clinical Results After Cardiac Surgery: A Meta-Analysis and Systematic Review
title_full	Association Between the Circulating Level of 25-Hydroxyvitamin D and Clinical Results After Cardiac Surgery: A Meta-Analysis and Systematic Review
title_fullStr	Association Between the Circulating Level of 25-Hydroxyvitamin D and Clinical Results After Cardiac Surgery: A Meta-Analysis and Systematic Review
title_full_unstemmed	Association Between the Circulating Level of 25-Hydroxyvitamin D and Clinical Results After Cardiac Surgery: A Meta-Analysis and Systematic Review
title_sort	association between the circulating level of 25-hydroxyvitamin d and clinical results after cardiac surgery: a meta-analysis and systematic review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9b03dc802de44991aaa0fbfcd1097941
work_keys_str_mv	AT yulinzhang associationbetweenthecirculatinglevelof25hydroxyvitamindandclinicalresultsaftercardiacsurgeryametaanalysisandsystematicreview AT jiawenli associationbetweenthecirculatinglevelof25hydroxyvitamindandclinicalresultsaftercardiacsurgeryametaanalysisandsystematicreview AT yuqiu associationbetweenthecirculatinglevelof25hydroxyvitamindandclinicalresultsaftercardiacsurgeryametaanalysisandsystematicreview AT xuegong associationbetweenthecirculatinglevelof25hydroxyvitamindandclinicalresultsaftercardiacsurgeryametaanalysisandsystematicreview AT yunruhe associationbetweenthecirculatinglevelof25hydroxyvitamindandclinicalresultsaftercardiacsurgeryametaanalysisandsystematicreview AT pengyue associationbetweenthecirculatinglevelof25hydroxyvitamindandclinicalresultsaftercardiacsurgeryametaanalysisandsystematicreview AT xiaolanzheng associationbetweenthecirculatinglevelof25hydroxyvitamindandclinicalresultsaftercardiacsurgeryametaanalysisandsystematicreview AT leiliu associationbetweenthecirculatinglevelof25hydroxyvitamindandclinicalresultsaftercardiacsurgeryametaanalysisandsystematicreview AT hongyuliao associationbetweenthecirculatinglevelof25hydroxyvitamindandclinicalresultsaftercardiacsurgeryametaanalysisandsystematicreview AT kaiyuzhou associationbetweenthecirculatinglevelof25hydroxyvitamindandclinicalresultsaftercardiacsurgeryametaanalysisandsystematicreview AT yiminhua associationbetweenthecirculatinglevelof25hydroxyvitamindandclinicalresultsaftercardiacsurgeryametaanalysisandsystematicreview AT yifeili associationbetweenthecirculatinglevelof25hydroxyvitamindandclinicalresultsaftercardiacsurgeryametaanalysisandsystematicreview
_version_	1718428568986320896

Association Between the Circulating Level of 25-Hydroxyvitamin D and Clinical Results After Cardiac Surgery: A Meta-Analysis and Systematic Review

Ejemplares similares