Treatment of myoclonic seizures in patients with juvenile myoclonic epilepsy

Treatment of myoclonic seizures in patients with juvenile myoclonic epilepsy

Stéphane AuvinDepartment of Pediatric Neurology, Lille University Hospital, Lille, France; Pharmacology Laboratory, Lille Medical School, Lille, FranceAbstract: Drug treatment of Juvenile myoclonic epilepsy (JME) is mainly based on clinical experience and prospective and retrospective...

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Autor principal: Stéphane Auvin
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2007
Materias:
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/9b04f17b927043a79727885a2605500e
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spelling oai:doaj.org-article:9b04f17b927043a79727885a2605500e2021-12-02T02:01:01ZTreatment of myoclonic seizures in patients with juvenile myoclonic epilepsy1176-63281178-2021https://doaj.org/article/9b04f17b927043a79727885a2605500e2007-01-01T00:00:00Zhttp://www.dovepress.com/treatment-of-myoclonic-seizures-in-patients-with-juvenile-myoclonic-ep-a953https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Stéphane AuvinDepartment of Pediatric Neurology, Lille University Hospital, Lille, France; Pharmacology Laboratory, Lille Medical School, Lille, FranceAbstract: Drug treatment of Juvenile myoclonic epilepsy (JME) is mainly based on clinical experience and prospective and retrospective studies, with little evidence from randomized clinical trials. There are no head-to-head comparisons between old and new antiepileptic drugs (AEDs) and no drugs licensed specifically for JME. Valproate is unquestionably the drug of the first choice in men with JME. In women, lamotrigine should be preferred regarding teratogenicity and side effects of valproate. In addition, levetiracetam and topiramate are effective and can be use in combination or as second line treatment. Some AEDs can aggravate JME. In addition of AEDs, non-pharmacological treatments are important in JME. JME usually require lifelong treatment because seizures nearly always return after withdrawal of therapy.Keywords: myoclonic seizure, myoclonic epilepsy, antiepileptic drugs Stéphane AuvinDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2007, Iss Issue 6, Pp 729-734 (2007)
institution DOAJ
collection DOAJ
language EN
topic Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Stéphane Auvin
Treatment of myoclonic seizures in patients with juvenile myoclonic epilepsy
description Stéphane AuvinDepartment of Pediatric Neurology, Lille University Hospital, Lille, France; Pharmacology Laboratory, Lille Medical School, Lille, FranceAbstract: Drug treatment of Juvenile myoclonic epilepsy (JME) is mainly based on clinical experience and prospective and retrospective studies, with little evidence from randomized clinical trials. There are no head-to-head comparisons between old and new antiepileptic drugs (AEDs) and no drugs licensed specifically for JME. Valproate is unquestionably the drug of the first choice in men with JME. In women, lamotrigine should be preferred regarding teratogenicity and side effects of valproate. In addition, levetiracetam and topiramate are effective and can be use in combination or as second line treatment. Some AEDs can aggravate JME. In addition of AEDs, non-pharmacological treatments are important in JME. JME usually require lifelong treatment because seizures nearly always return after withdrawal of therapy.Keywords: myoclonic seizure, myoclonic epilepsy, antiepileptic drugs
format article
author Stéphane Auvin
author_facet Stéphane Auvin
author_sort Stéphane Auvin
title Treatment of myoclonic seizures in patients with juvenile myoclonic epilepsy
title_short Treatment of myoclonic seizures in patients with juvenile myoclonic epilepsy
title_full Treatment of myoclonic seizures in patients with juvenile myoclonic epilepsy
title_fullStr Treatment of myoclonic seizures in patients with juvenile myoclonic epilepsy
title_full_unstemmed Treatment of myoclonic seizures in patients with juvenile myoclonic epilepsy
title_sort treatment of myoclonic seizures in patients with juvenile myoclonic epilepsy
publisher Dove Medical Press
publishDate 2007
url https://doaj.org/article/9b04f17b927043a79727885a2605500e
work_keys_str_mv AT stampeacutephaneauvin treatmentofmyoclonicseizuresinpatientswithjuvenilemyoclonicepilepsy
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