Preoperative imaging findings in patients undergoing transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy

Abstract The prevalence and impact of imaging findings detected during screening procedures in patients undergoing transcranial MR-guided Focused Ultrasound (tcMRgFUS) thalamotomy for functional neurological disorders has not been assessed yet. This study included 90 patients who fully completed cli...

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Autores principales:	Cesare Gagliardo, Roberto Cannella, Giuseppe Filorizzo, Patrizia Toia, Giuseppe Salvaggio, Giorgio Collura, Antonia Pignolo, Rosario Maugeri, Alessandro Napoli, Marco D’amelio, Tommaso Vincenzo Bartolotta, Maurizio Marrale, Gerardo Domenico Iacopino, Carlo Catalano, Massimo Midiri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9b0a9121d3a0488b8605ff50ef68be9f
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spelling	oai:doaj.org-article:9b0a9121d3a0488b8605ff50ef68be9f2021-12-02T13:57:24ZPreoperative imaging findings in patients undergoing transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy10.1038/s41598-021-82271-82045-2322https://doaj.org/article/9b0a9121d3a0488b8605ff50ef68be9f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82271-8https://doaj.org/toc/2045-2322Abstract The prevalence and impact of imaging findings detected during screening procedures in patients undergoing transcranial MR-guided Focused Ultrasound (tcMRgFUS) thalamotomy for functional neurological disorders has not been assessed yet. This study included 90 patients who fully completed clinical and neuroradiological screenings for tcMRgFUS in a single-center. The presence and location of preoperative imaging findings that could impact the treatment were recorded and classified in three different groups according to their relevance for the eligibility and treatment planning. Furthermore, tcMRgFUS treatments were reviewed to evaluate the number of transducer elements turned off after marking as no pass regions the depicted imaging finding. A total of 146 preoperative imaging findings in 79 (87.8%) patients were detected in the screening population, with a significant correlation with patients’ age (rho = 483, p < 0.001). With regard of the group classification, 119 (81.5%), 26 (17.8%) were classified as group 1 or 2, respectively. One patient had group 3 finding and was considered ineligible. No complications related to the preoperative imaging findings occurred in treated patients. Preoperative neuroradiological findings are frequent in candidates to tcMRgFUS and their identification may require the placement of additional no-pass regions to prevent harmful non-targeted heating.Cesare GagliardoRoberto CannellaGiuseppe FilorizzoPatrizia ToiaGiuseppe SalvaggioGiorgio ColluraAntonia PignoloRosario MaugeriAlessandro NapoliMarco D’amelioTommaso Vincenzo BartolottaMaurizio MarraleGerardo Domenico IacopinoCarlo CatalanoMassimo MidiriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cesare Gagliardo Roberto Cannella Giuseppe Filorizzo Patrizia Toia Giuseppe Salvaggio Giorgio Collura Antonia Pignolo Rosario Maugeri Alessandro Napoli Marco D’amelio Tommaso Vincenzo Bartolotta Maurizio Marrale Gerardo Domenico Iacopino Carlo Catalano Massimo Midiri Preoperative imaging findings in patients undergoing transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy
description	Abstract The prevalence and impact of imaging findings detected during screening procedures in patients undergoing transcranial MR-guided Focused Ultrasound (tcMRgFUS) thalamotomy for functional neurological disorders has not been assessed yet. This study included 90 patients who fully completed clinical and neuroradiological screenings for tcMRgFUS in a single-center. The presence and location of preoperative imaging findings that could impact the treatment were recorded and classified in three different groups according to their relevance for the eligibility and treatment planning. Furthermore, tcMRgFUS treatments were reviewed to evaluate the number of transducer elements turned off after marking as no pass regions the depicted imaging finding. A total of 146 preoperative imaging findings in 79 (87.8%) patients were detected in the screening population, with a significant correlation with patients’ age (rho = 483, p < 0.001). With regard of the group classification, 119 (81.5%), 26 (17.8%) were classified as group 1 or 2, respectively. One patient had group 3 finding and was considered ineligible. No complications related to the preoperative imaging findings occurred in treated patients. Preoperative neuroradiological findings are frequent in candidates to tcMRgFUS and their identification may require the placement of additional no-pass regions to prevent harmful non-targeted heating.
format	article
author	Cesare Gagliardo Roberto Cannella Giuseppe Filorizzo Patrizia Toia Giuseppe Salvaggio Giorgio Collura Antonia Pignolo Rosario Maugeri Alessandro Napoli Marco D’amelio Tommaso Vincenzo Bartolotta Maurizio Marrale Gerardo Domenico Iacopino Carlo Catalano Massimo Midiri
author_facet	Cesare Gagliardo Roberto Cannella Giuseppe Filorizzo Patrizia Toia Giuseppe Salvaggio Giorgio Collura Antonia Pignolo Rosario Maugeri Alessandro Napoli Marco D’amelio Tommaso Vincenzo Bartolotta Maurizio Marrale Gerardo Domenico Iacopino Carlo Catalano Massimo Midiri
author_sort	Cesare Gagliardo
title	Preoperative imaging findings in patients undergoing transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy
title_short	Preoperative imaging findings in patients undergoing transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy
title_full	Preoperative imaging findings in patients undergoing transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy
title_fullStr	Preoperative imaging findings in patients undergoing transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy
title_full_unstemmed	Preoperative imaging findings in patients undergoing transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy
title_sort	preoperative imaging findings in patients undergoing transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9b0a9121d3a0488b8605ff50ef68be9f
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Preoperative imaging findings in patients undergoing transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy

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