The potential protective role of corticosteroid therapy in patients with asthma and COPD against COVID-19

Abstract Background The observation of patients hospitalized for coronavirus disease (COVID-19) led us to note a lower prevalence of patients affected by chronic respiratory disease, in particular asthmatic patients, compared to the general population. Therefore, the aim of this paper is to evaluate...

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Autores principales:	Fabiana Furci, Marco Caminati, Gianenrico Senna, Sebastiano Gangemi
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	COVID-19 Hospitalization Asthma COPD Corticosteroids Pulmonary diseases Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/9b0b360605594d36b38cf0deb56612de
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spelling	oai:doaj.org-article:9b0b360605594d36b38cf0deb56612de2021-11-08T10:56:38ZThe potential protective role of corticosteroid therapy in patients with asthma and COPD against COVID-1910.1186/s12948-021-00159-41476-7961https://doaj.org/article/9b0b360605594d36b38cf0deb56612de2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12948-021-00159-4https://doaj.org/toc/1476-7961Abstract Background The observation of patients hospitalized for coronavirus disease (COVID-19) led us to note a lower prevalence of patients affected by chronic respiratory disease, in particular asthmatic patients, compared to the general population. Therefore, the aim of this paper is to evaluate the possible protective role of corticosteroid therapy in patients with chronic lung disease, regarding the risk of contracting severe COVID-19. Main body SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) receptors to enter the cells. Considering the high number of these receptors in patients affected by asthma and chronic obstructive pulmonary disease (COPD), the evidence that these patients do not have a high risk of hospitalization for COVID-19 needs further study to understand what the possible protective “factors” are in these patients. In particular, the finding in some studies of reduced coronavirus replication in cell lines treated with steroids, molecules commonly used for treating chronic lung diseases, needs further attention. Short conclusion The hypothesis that corticosteroids, commonly used in treating airways diseases, might modify the severity of SARS-CoV-2 disease has become a key point and a possible predictive factor of a positive outcome of COVID-19 in patients treated everyday with these molecules.Fabiana FurciMarco CaminatiGianenrico SennaSebastiano GangemiBMCarticleCOVID-19HospitalizationAsthmaCOPDCorticosteroidsPulmonary diseasesImmunologic diseases. AllergyRC581-607ENClinical and Molecular Allergy, Vol 19, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 Hospitalization Asthma COPD Corticosteroids Pulmonary diseases Immunologic diseases. Allergy RC581-607
spellingShingle	COVID-19 Hospitalization Asthma COPD Corticosteroids Pulmonary diseases Immunologic diseases. Allergy RC581-607 Fabiana Furci Marco Caminati Gianenrico Senna Sebastiano Gangemi The potential protective role of corticosteroid therapy in patients with asthma and COPD against COVID-19
description	Abstract Background The observation of patients hospitalized for coronavirus disease (COVID-19) led us to note a lower prevalence of patients affected by chronic respiratory disease, in particular asthmatic patients, compared to the general population. Therefore, the aim of this paper is to evaluate the possible protective role of corticosteroid therapy in patients with chronic lung disease, regarding the risk of contracting severe COVID-19. Main body SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) receptors to enter the cells. Considering the high number of these receptors in patients affected by asthma and chronic obstructive pulmonary disease (COPD), the evidence that these patients do not have a high risk of hospitalization for COVID-19 needs further study to understand what the possible protective “factors” are in these patients. In particular, the finding in some studies of reduced coronavirus replication in cell lines treated with steroids, molecules commonly used for treating chronic lung diseases, needs further attention. Short conclusion The hypothesis that corticosteroids, commonly used in treating airways diseases, might modify the severity of SARS-CoV-2 disease has become a key point and a possible predictive factor of a positive outcome of COVID-19 in patients treated everyday with these molecules.
format	article
author	Fabiana Furci Marco Caminati Gianenrico Senna Sebastiano Gangemi
author_facet	Fabiana Furci Marco Caminati Gianenrico Senna Sebastiano Gangemi
author_sort	Fabiana Furci
title	The potential protective role of corticosteroid therapy in patients with asthma and COPD against COVID-19
title_short	The potential protective role of corticosteroid therapy in patients with asthma and COPD against COVID-19
title_full	The potential protective role of corticosteroid therapy in patients with asthma and COPD against COVID-19
title_fullStr	The potential protective role of corticosteroid therapy in patients with asthma and COPD against COVID-19
title_full_unstemmed	The potential protective role of corticosteroid therapy in patients with asthma and COPD against COVID-19
title_sort	potential protective role of corticosteroid therapy in patients with asthma and copd against covid-19
publisher	BMC
publishDate	2021
url	https://doaj.org/article/9b0b360605594d36b38cf0deb56612de
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The potential protective role of corticosteroid therapy in patients with asthma and COPD against COVID-19

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