Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells

Rore et al generate testicular somatic cell-like cells (TesLCs) including Sertoli cell-like cells from mouse embryonic stem cells in xeno-free culture. They created testicular organoids in aggregation co-culture of TesLCs and epiblast-like cells (EpiLCs) and also find that TesLC-conditioned media pr...

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Autores principales:	Holly Rore, Nicholas Owen, Raul Eduardo Piña-Aguilar, Kevin Docherty, Ryohei Sekido
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9b0d77b189cb48598785fe29b0ee4f1d
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spelling	oai:doaj.org-article:9b0d77b189cb48598785fe29b0ee4f1d2021-12-02T16:10:32ZTesticular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells10.1038/s42003-021-02322-82399-3642https://doaj.org/article/9b0d77b189cb48598785fe29b0ee4f1d2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02322-8https://doaj.org/toc/2399-3642Rore et al generate testicular somatic cell-like cells (TesLCs) including Sertoli cell-like cells from mouse embryonic stem cells in xeno-free culture. They created testicular organoids in aggregation co-culture of TesLCs and epiblast-like cells (EpiLCs) and also find that TesLC-conditioned media promotes the differentiation of EpiLCs into primordial germ-like cells (PGCLCs).Holly RoreNicholas OwenRaul Eduardo Piña-AguilarKevin DochertyRyohei SekidoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Holly Rore Nicholas Owen Raul Eduardo Piña-Aguilar Kevin Docherty Ryohei Sekido Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells
description	Rore et al generate testicular somatic cell-like cells (TesLCs) including Sertoli cell-like cells from mouse embryonic stem cells in xeno-free culture. They created testicular organoids in aggregation co-culture of TesLCs and epiblast-like cells (EpiLCs) and also find that TesLC-conditioned media promotes the differentiation of EpiLCs into primordial germ-like cells (PGCLCs).
format	article
author	Holly Rore Nicholas Owen Raul Eduardo Piña-Aguilar Kevin Docherty Ryohei Sekido
author_facet	Holly Rore Nicholas Owen Raul Eduardo Piña-Aguilar Kevin Docherty Ryohei Sekido
author_sort	Holly Rore
title	Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells
title_short	Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells
title_full	Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells
title_fullStr	Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells
title_full_unstemmed	Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells
title_sort	testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9b0d77b189cb48598785fe29b0ee4f1d
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Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells

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