bFGF and TGFbeta1 growth factors, inflammatory markers (IL-6, TNF-alpha, CRP) and advanced glycation end-products (AGE, RAGE) in patients with ischemic heart disease and type 2 diabetes mellitus

Aims. To evaluate plasma levels of transforming growth factor beta (TGFbeta1), basic fibroblast growth factor (bFGF), markers for nonspecific inflammatory process (interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), C-reactive protein (CRP)) and their putative correlation with advanced g...

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Autores principales:	Ekaterina Vladimirovna Ivannikova, Konstantin Vladimirovich Melkozerov, Victor Yur'evich Kalashnikov, Sergey Anatol'evich Terekhin, Irina Vladimirovna Kononenko, Olga Mikhailovna Smirnova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2013
Materias:	fibroblast growth factors diabetes mellitus ischemic heart diseases Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/9b0fbad2a6514d469b658ef544be064c
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spelling	oai:doaj.org-article:9b0fbad2a6514d469b658ef544be064c2021-11-14T09:00:18ZbFGF and TGFbeta1 growth factors, inflammatory markers (IL-6, TNF-alpha, CRP) and advanced glycation end-products (AGE, RAGE) in patients with ischemic heart disease and type 2 diabetes mellitus2072-03512072-037810.14341/2072-0351-819https://doaj.org/article/9b0fbad2a6514d469b658ef544be064c2013-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/819https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aims. To evaluate plasma levels of transforming growth factor beta (TGFbeta1), basic fibroblast growth factor (bFGF), markers for nonspecific inflammatory process (interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), C-reactive protein (CRP)) and their putative correlation with advanced glycation end-products relative to diabetes compensation in patients with ischemic heart disease (IHD). Materials and Methods. 87 patients with IHD were enrolled in this study. All subjects underwent standard clinical examination, including laboratory assessment of glycemic parameters, lipid panel and renal function, with echocardiography, supplemented with coronary angiography. Analyses for study parameters were performed on samples obtained from aorta and, separately, from cubital vein during coronary angiography. Results. Diabetes mellitus in patients with IHD is firmly associated with TGFbeta1, IL-6 and CRP elevation in both arterial and venous plasma. TGFbeta1 positively correlates with lipid profile parameters. Plasma concentration of inflammatory markers and advanced glycation end-products positively correlates with the extent of coronary lesions in relation to the presence of diabetes mellitus. Conclusion. Our data suggests the interplay between connective tissue growth factors and lipid metabolism in the atherosclerotic process.Ekaterina Vladimirovna IvannikovaKonstantin Vladimirovich MelkozerovVictor Yur'evich KalashnikovSergey Anatol'evich TerekhinIrina Vladimirovna KononenkoOlga Mikhailovna SmirnovaEndocrinology Research Centrearticlefibroblast growth factorsdiabetes mellitusischemic heart diseasesNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 16, Iss 3, Pp 64-70 (2013)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	fibroblast growth factors diabetes mellitus ischemic heart diseases Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	fibroblast growth factors diabetes mellitus ischemic heart diseases Nutritional diseases. Deficiency diseases RC620-627 Ekaterina Vladimirovna Ivannikova Konstantin Vladimirovich Melkozerov Victor Yur'evich Kalashnikov Sergey Anatol'evich Terekhin Irina Vladimirovna Kononenko Olga Mikhailovna Smirnova bFGF and TGFbeta1 growth factors, inflammatory markers (IL-6, TNF-alpha, CRP) and advanced glycation end-products (AGE, RAGE) in patients with ischemic heart disease and type 2 diabetes mellitus
description	Aims. To evaluate plasma levels of transforming growth factor beta (TGFbeta1), basic fibroblast growth factor (bFGF), markers for nonspecific inflammatory process (interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), C-reactive protein (CRP)) and their putative correlation with advanced glycation end-products relative to diabetes compensation in patients with ischemic heart disease (IHD). Materials and Methods. 87 patients with IHD were enrolled in this study. All subjects underwent standard clinical examination, including laboratory assessment of glycemic parameters, lipid panel and renal function, with echocardiography, supplemented with coronary angiography. Analyses for study parameters were performed on samples obtained from aorta and, separately, from cubital vein during coronary angiography. Results. Diabetes mellitus in patients with IHD is firmly associated with TGFbeta1, IL-6 and CRP elevation in both arterial and venous plasma. TGFbeta1 positively correlates with lipid profile parameters. Plasma concentration of inflammatory markers and advanced glycation end-products positively correlates with the extent of coronary lesions in relation to the presence of diabetes mellitus. Conclusion. Our data suggests the interplay between connective tissue growth factors and lipid metabolism in the atherosclerotic process.
format	article
author	Ekaterina Vladimirovna Ivannikova Konstantin Vladimirovich Melkozerov Victor Yur'evich Kalashnikov Sergey Anatol'evich Terekhin Irina Vladimirovna Kononenko Olga Mikhailovna Smirnova
author_facet	Ekaterina Vladimirovna Ivannikova Konstantin Vladimirovich Melkozerov Victor Yur'evich Kalashnikov Sergey Anatol'evich Terekhin Irina Vladimirovna Kononenko Olga Mikhailovna Smirnova
author_sort	Ekaterina Vladimirovna Ivannikova
title	bFGF and TGFbeta1 growth factors, inflammatory markers (IL-6, TNF-alpha, CRP) and advanced glycation end-products (AGE, RAGE) in patients with ischemic heart disease and type 2 diabetes mellitus
title_short	bFGF and TGFbeta1 growth factors, inflammatory markers (IL-6, TNF-alpha, CRP) and advanced glycation end-products (AGE, RAGE) in patients with ischemic heart disease and type 2 diabetes mellitus
title_full	bFGF and TGFbeta1 growth factors, inflammatory markers (IL-6, TNF-alpha, CRP) and advanced glycation end-products (AGE, RAGE) in patients with ischemic heart disease and type 2 diabetes mellitus
title_fullStr	bFGF and TGFbeta1 growth factors, inflammatory markers (IL-6, TNF-alpha, CRP) and advanced glycation end-products (AGE, RAGE) in patients with ischemic heart disease and type 2 diabetes mellitus
title_full_unstemmed	bFGF and TGFbeta1 growth factors, inflammatory markers (IL-6, TNF-alpha, CRP) and advanced glycation end-products (AGE, RAGE) in patients with ischemic heart disease and type 2 diabetes mellitus
title_sort	bfgf and tgfbeta1 growth factors, inflammatory markers (il-6, tnf-alpha, crp) and advanced glycation end-products (age, rage) in patients with ischemic heart disease and type 2 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2013
url	https://doaj.org/article/9b0fbad2a6514d469b658ef544be064c
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bFGF and TGFbeta1 growth factors, inflammatory markers (IL-6, TNF-alpha, CRP) and advanced glycation end-products (AGE, RAGE) in patients with ischemic heart disease and type 2 diabetes mellitus

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