Macrophage-biomimetic porous Se@SiO2 nanocomposites for dual modal immunotherapy against inflammatory osteolysis

Abstract Background Inflammatory osteolysis, a major complication of total joint replacement surgery, can cause prosthesis failure and necessitate revision surgery. Macrophages are key effector immune cells in inflammatory responses, but excessive M1-polarization of dysfunctional macrophages leads t...

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Autores principales:	Cheng Ding, Chuang Yang, Tao Cheng, Xingyan Wang, Qiaojie Wang, Renke He, Shang Sang, Kechao Zhu, Dongdong Xu, Jiaxing Wang, Xijian Liu, Xianlong Zhang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Biomimetic nanoparticle Porous Se@SiO2 nanospheres Macrophage polarization Osteolysis Immunomodulation Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/9b1124ab7b22439f9b6250b3c632546b
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spelling	oai:doaj.org-article:9b1124ab7b22439f9b6250b3c632546b2021-11-28T12:26:41ZMacrophage-biomimetic porous Se@SiO2 nanocomposites for dual modal immunotherapy against inflammatory osteolysis10.1186/s12951-021-01128-41477-3155https://doaj.org/article/9b1124ab7b22439f9b6250b3c632546b2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12951-021-01128-4https://doaj.org/toc/1477-3155Abstract Background Inflammatory osteolysis, a major complication of total joint replacement surgery, can cause prosthesis failure and necessitate revision surgery. Macrophages are key effector immune cells in inflammatory responses, but excessive M1-polarization of dysfunctional macrophages leads to the secretion of proinflammatory cytokines and severe loss of bone tissue. Here, we report the development of macrophage-biomimetic porous SiO2-coated ultrasmall Se particles (porous Se@SiO2 nanospheres) to manage inflammatory osteolysis. Results Macrophage membrane-coated porous Se@SiO2 nanospheres(M-Se@SiO2) attenuated lipopolysaccharide (LPS)-induced inflammatory osteolysis via a dual-immunomodulatory effect. As macrophage membrane decoys, these nanoparticles reduced endotoxin levels and neutralized proinflammatory cytokines. Moreover, the release of Se could induce macrophage polarization toward the anti-inflammatory M2-phenotype. These effects were mediated via the inhibition of p65, p38, and extracellular signal-regulated kinase (ERK) signaling. Additionally, the immune environment created by M-Se@SiO2 reduced the inhibition of osteogenic differentiation caused by proinflammation cytokines, as confirmed through in vitro and in vivo experiments. Conclusion Our findings suggest that M-Se@SiO2 have an immunomodulatory role in LPS-induced inflammation and bone remodeling, which demonstrates that M-Se@SiO2 are a promising engineered nanoplatform for the treatment of osteolysis occurring after arthroplasty. Graphical AbstractCheng DingChuang YangTao ChengXingyan WangQiaojie WangRenke HeShang SangKechao ZhuDongdong XuJiaxing WangXijian LiuXianlong ZhangBMCarticleBiomimetic nanoparticlePorous Se@SiO2 nanospheresMacrophage polarizationOsteolysisImmunomodulationBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENJournal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biomimetic nanoparticle Porous Se@SiO2 nanospheres Macrophage polarization Osteolysis Immunomodulation Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	Biomimetic nanoparticle Porous Se@SiO2 nanospheres Macrophage polarization Osteolysis Immunomodulation Biotechnology TP248.13-248.65 Medical technology R855-855.5 Cheng Ding Chuang Yang Tao Cheng Xingyan Wang Qiaojie Wang Renke He Shang Sang Kechao Zhu Dongdong Xu Jiaxing Wang Xijian Liu Xianlong Zhang Macrophage-biomimetic porous Se@SiO2 nanocomposites for dual modal immunotherapy against inflammatory osteolysis
description	Abstract Background Inflammatory osteolysis, a major complication of total joint replacement surgery, can cause prosthesis failure and necessitate revision surgery. Macrophages are key effector immune cells in inflammatory responses, but excessive M1-polarization of dysfunctional macrophages leads to the secretion of proinflammatory cytokines and severe loss of bone tissue. Here, we report the development of macrophage-biomimetic porous SiO2-coated ultrasmall Se particles (porous Se@SiO2 nanospheres) to manage inflammatory osteolysis. Results Macrophage membrane-coated porous Se@SiO2 nanospheres(M-Se@SiO2) attenuated lipopolysaccharide (LPS)-induced inflammatory osteolysis via a dual-immunomodulatory effect. As macrophage membrane decoys, these nanoparticles reduced endotoxin levels and neutralized proinflammatory cytokines. Moreover, the release of Se could induce macrophage polarization toward the anti-inflammatory M2-phenotype. These effects were mediated via the inhibition of p65, p38, and extracellular signal-regulated kinase (ERK) signaling. Additionally, the immune environment created by M-Se@SiO2 reduced the inhibition of osteogenic differentiation caused by proinflammation cytokines, as confirmed through in vitro and in vivo experiments. Conclusion Our findings suggest that M-Se@SiO2 have an immunomodulatory role in LPS-induced inflammation and bone remodeling, which demonstrates that M-Se@SiO2 are a promising engineered nanoplatform for the treatment of osteolysis occurring after arthroplasty. Graphical Abstract
format	article
author	Cheng Ding Chuang Yang Tao Cheng Xingyan Wang Qiaojie Wang Renke He Shang Sang Kechao Zhu Dongdong Xu Jiaxing Wang Xijian Liu Xianlong Zhang
author_facet	Cheng Ding Chuang Yang Tao Cheng Xingyan Wang Qiaojie Wang Renke He Shang Sang Kechao Zhu Dongdong Xu Jiaxing Wang Xijian Liu Xianlong Zhang
author_sort	Cheng Ding
title	Macrophage-biomimetic porous Se@SiO2 nanocomposites for dual modal immunotherapy against inflammatory osteolysis
title_short	Macrophage-biomimetic porous Se@SiO2 nanocomposites for dual modal immunotherapy against inflammatory osteolysis
title_full	Macrophage-biomimetic porous Se@SiO2 nanocomposites for dual modal immunotherapy against inflammatory osteolysis
title_fullStr	Macrophage-biomimetic porous Se@SiO2 nanocomposites for dual modal immunotherapy against inflammatory osteolysis
title_full_unstemmed	Macrophage-biomimetic porous Se@SiO2 nanocomposites for dual modal immunotherapy against inflammatory osteolysis
title_sort	macrophage-biomimetic porous se@sio2 nanocomposites for dual modal immunotherapy against inflammatory osteolysis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/9b1124ab7b22439f9b6250b3c632546b
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_version_	1718407972051222528

Macrophage-biomimetic porous Se@SiO2 nanocomposites for dual modal immunotherapy against inflammatory osteolysis

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