Macrophage-biomimetic porous Se@SiO2 nanocomposites for dual modal immunotherapy against inflammatory osteolysis

Macrophage-biomimetic porous Se@SiO2 nanocomposites for dual modal immunotherapy against inflammatory osteolysis

Abstract Background Inflammatory osteolysis, a major complication of total joint replacement surgery, can cause prosthesis failure and necessitate revision surgery. Macrophages are key effector immune cells in inflammatory responses, but excessive M1-polarization of dysfunctional macrophages leads t...

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Bibliographic Details
Main Authors: Cheng Ding, Chuang Yang, Tao Cheng, Xingyan Wang, Qiaojie Wang, Renke He, Shang Sang, Kechao Zhu, Dongdong Xu, Jiaxing Wang, Xijian Liu, Xianlong Zhang
Format: article
Language:EN
Published: BMC 2021
Subjects:
Biomimetic nanoparticle
Porous Se@SiO2 nanospheres
Macrophage polarization
Osteolysis
Immunomodulation
Biotechnology
TP248.13-248.65
Medical technology
R855-855.5
Online Access:https://doaj.org/article/9b1124ab7b22439f9b6250b3c632546b
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https://doaj.org/article/9b1124ab7b22439f9b6250b3c632546b

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