Inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study

Abstract Little is known about middle and inner ear development during the second and third parts of human fetal life. Using ultra-high resolution Microcomputed Tomography coupled with bone histology, we performed the first quantitative middle and inner ear ossification/mineralization evaluation of...

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Autores principales:	Céline Richard, Guillaume Courbon, Norbert Laroche, Jean Michel Prades, Laurence Vico, Luc Malaval
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9b1b4140fa4642ffb08be00b9e3cdd02
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spelling	oai:doaj.org-article:9b1b4140fa4642ffb08be00b9e3cdd022021-12-02T15:05:50ZInner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study10.1038/s41598-017-05151-02045-2322https://doaj.org/article/9b1b4140fa4642ffb08be00b9e3cdd022017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05151-0https://doaj.org/toc/2045-2322Abstract Little is known about middle and inner ear development during the second and third parts of human fetal life. Using ultra-high resolution Microcomputed Tomography coupled with bone histology, we performed the first quantitative middle and inner ear ossification/mineralization evaluation of fetuses between 17 and 39 weeks of gestational age. We show distinct ossification paces between ossicles, with a belated development of the stapes. A complete cochlear bony covering is observed within the time-frame of the onset of hearing, whereas distinct time courses of ossification for semicircular canal envelopes are observed in relation to the start of vestibular functions. The study evidences a spatio-temporal relationship between middle and inner ear structure development and the onset of hearing and balance, critical senses for the fetal adaptation to birth.Céline RichardGuillaume CourbonNorbert LarocheJean Michel PradesLaurence VicoLuc MalavalNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Céline Richard Guillaume Courbon Norbert Laroche Jean Michel Prades Laurence Vico Luc Malaval Inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study
description	Abstract Little is known about middle and inner ear development during the second and third parts of human fetal life. Using ultra-high resolution Microcomputed Tomography coupled with bone histology, we performed the first quantitative middle and inner ear ossification/mineralization evaluation of fetuses between 17 and 39 weeks of gestational age. We show distinct ossification paces between ossicles, with a belated development of the stapes. A complete cochlear bony covering is observed within the time-frame of the onset of hearing, whereas distinct time courses of ossification for semicircular canal envelopes are observed in relation to the start of vestibular functions. The study evidences a spatio-temporal relationship between middle and inner ear structure development and the onset of hearing and balance, critical senses for the fetal adaptation to birth.
format	article
author	Céline Richard Guillaume Courbon Norbert Laroche Jean Michel Prades Laurence Vico Luc Malaval
author_facet	Céline Richard Guillaume Courbon Norbert Laroche Jean Michel Prades Laurence Vico Luc Malaval
author_sort	Céline Richard
title	Inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study
title_short	Inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study
title_full	Inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study
title_fullStr	Inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study
title_full_unstemmed	Inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study
title_sort	inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9b1b4140fa4642ffb08be00b9e3cdd02
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Inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study

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