N-palmitoylethanolamine and N-acetylethanolamine are effective in asteatotic eczema: results of a randomized, double-blind, controlled study in 60 patients

Chao Yuan,1,* Xue-Min Wang,1,* Alexandre Guichard,2 Yi-Mei Tan,1 Chun-Yan Qian,1 Li-Jie Yang,1 Philippe Humbert2 1Department of Skin and Cosmetic Research, Shanghai Skin Disease Hospital, Shanghai, People’s Republic of China; 2Research and Studies Center on the Integument, Department of D...

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Autores principales:	Yuan C, Wang XM, Guichard A, Tan YM, Qian CY, Yang LJ, Humbert P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	N-palmitoylethanolamine (PEA) N-acetylethanolamine (AEA) Current Perception Threshold (CPT) Skin barrier pruritus Asteatotic Eczema. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/9b1bf0e05bd84c96935f9eb95eefbee5
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spelling	oai:doaj.org-article:9b1bf0e05bd84c96935f9eb95eefbee52021-12-02T00:10:32ZN-palmitoylethanolamine and N-acetylethanolamine are effective in asteatotic eczema: results of a randomized, double-blind, controlled study in 60 patients1178-1998https://doaj.org/article/9b1bf0e05bd84c96935f9eb95eefbee52014-07-01T00:00:00Zhttps://www.dovepress.com/n-palmitoylethanolamine-and-n-acetylethanolamine-are-effective-in-aste-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Chao Yuan,1,* Xue-Min Wang,1,* Alexandre Guichard,2 Yi-Mei Tan,1 Chun-Yan Qian,1 Li-Jie Yang,1 Philippe Humbert2 1Department of Skin and Cosmetic Research, Shanghai Skin Disease Hospital, Shanghai, People’s Republic of China; 2Research and Studies Center on the Integument, Department of Dermatology, Besançon University Hospital, University of Franche-Comté, Franche-Comté, France *These authors contributed equally to this work Background: Asteatotic eczema (AE) is characterized by itchy, dry, rough, and scaling skin. The treatments for AE are mainly emollients, usually containing urea, lactic acid, or a lactate salt. N-palmitoylethanolamine (PEA) and N-acetylethanolamine (AEA) are both endogenous lipids used as novel therapeutic tools in the treatment of many skin diseases. The purpose of this study was to compare a PEA/AEA emollient with a traditional emollient in the treatment of AE. Methods: A monocentric, randomized, double-blind, comparative trial was conducted in 60 AE patients to evaluate and compare the efficacy of the two emollients. The level of skin dryness among the subjects ranged from mild to moderate. The subjects’ skin barrier function and the current perception threshold were tested for 28 days by clinical scoring and bioengineering technology. Results: The results showed that, although some aspects were improved in both groups, the group using the emollient containing PEA/AEA presented a better skin surface change in capacitance. However, the most impressive finding was the ability of the PEA/AEA emollient to increase the 5 Hz current perception threshold to a normal level after 7 days, with a significant difference between values at baseline and after 14 days. A current perception threshold of 5 Hz was positively and significantly correlated with skin surface hydration and negatively correlated with transepidermal water loss in the PEA/AEA emollient group. Conclusion: Compared with traditional emollients, regular application of a topical PEA/AEA emollient could improve both passive and active skin functions simultaneously. Keywords: N-palmitoylethanolamine, N-acetylethanolamine, current perception threshold, skin barrier, pruritus, asteatotic eczemaYuan CWang XMGuichard ATan YMQian CYYang LJHumbert PDove Medical PressarticleN-palmitoylethanolamine (PEA)N-acetylethanolamine (AEA)Current Perception Threshold (CPT)Skin barrierpruritusAsteatotic Eczema.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 9, Pp 1163-1169 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	N-palmitoylethanolamine (PEA) N-acetylethanolamine (AEA) Current Perception Threshold (CPT) Skin barrier pruritus Asteatotic Eczema. Geriatrics RC952-954.6
spellingShingle	N-palmitoylethanolamine (PEA) N-acetylethanolamine (AEA) Current Perception Threshold (CPT) Skin barrier pruritus Asteatotic Eczema. Geriatrics RC952-954.6 Yuan C Wang XM Guichard A Tan YM Qian CY Yang LJ Humbert P N-palmitoylethanolamine and N-acetylethanolamine are effective in asteatotic eczema: results of a randomized, double-blind, controlled study in 60 patients
description	Chao Yuan,1,* Xue-Min Wang,1,* Alexandre Guichard,2 Yi-Mei Tan,1 Chun-Yan Qian,1 Li-Jie Yang,1 Philippe Humbert2 1Department of Skin and Cosmetic Research, Shanghai Skin Disease Hospital, Shanghai, People’s Republic of China; 2Research and Studies Center on the Integument, Department of Dermatology, Besançon University Hospital, University of Franche-Comté, Franche-Comté, France *These authors contributed equally to this work Background: Asteatotic eczema (AE) is characterized by itchy, dry, rough, and scaling skin. The treatments for AE are mainly emollients, usually containing urea, lactic acid, or a lactate salt. N-palmitoylethanolamine (PEA) and N-acetylethanolamine (AEA) are both endogenous lipids used as novel therapeutic tools in the treatment of many skin diseases. The purpose of this study was to compare a PEA/AEA emollient with a traditional emollient in the treatment of AE. Methods: A monocentric, randomized, double-blind, comparative trial was conducted in 60 AE patients to evaluate and compare the efficacy of the two emollients. The level of skin dryness among the subjects ranged from mild to moderate. The subjects’ skin barrier function and the current perception threshold were tested for 28 days by clinical scoring and bioengineering technology. Results: The results showed that, although some aspects were improved in both groups, the group using the emollient containing PEA/AEA presented a better skin surface change in capacitance. However, the most impressive finding was the ability of the PEA/AEA emollient to increase the 5 Hz current perception threshold to a normal level after 7 days, with a significant difference between values at baseline and after 14 days. A current perception threshold of 5 Hz was positively and significantly correlated with skin surface hydration and negatively correlated with transepidermal water loss in the PEA/AEA emollient group. Conclusion: Compared with traditional emollients, regular application of a topical PEA/AEA emollient could improve both passive and active skin functions simultaneously. Keywords: N-palmitoylethanolamine, N-acetylethanolamine, current perception threshold, skin barrier, pruritus, asteatotic eczema
format	article
author	Yuan C Wang XM Guichard A Tan YM Qian CY Yang LJ Humbert P
author_facet	Yuan C Wang XM Guichard A Tan YM Qian CY Yang LJ Humbert P
author_sort	Yuan C
title	N-palmitoylethanolamine and N-acetylethanolamine are effective in asteatotic eczema: results of a randomized, double-blind, controlled study in 60 patients
title_short	N-palmitoylethanolamine and N-acetylethanolamine are effective in asteatotic eczema: results of a randomized, double-blind, controlled study in 60 patients
title_full	N-palmitoylethanolamine and N-acetylethanolamine are effective in asteatotic eczema: results of a randomized, double-blind, controlled study in 60 patients
title_fullStr	N-palmitoylethanolamine and N-acetylethanolamine are effective in asteatotic eczema: results of a randomized, double-blind, controlled study in 60 patients
title_full_unstemmed	N-palmitoylethanolamine and N-acetylethanolamine are effective in asteatotic eczema: results of a randomized, double-blind, controlled study in 60 patients
title_sort	n-palmitoylethanolamine and n-acetylethanolamine are effective in asteatotic eczema: results of a randomized, double-blind, controlled study in 60 patients
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/9b1bf0e05bd84c96935f9eb95eefbee5
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N-palmitoylethanolamine and N-acetylethanolamine are effective in asteatotic eczema: results of a randomized, double-blind, controlled study in 60 patients

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