CHANGES OF HLA-DR ANTIGEN EXPRESSION ON MONOCYTES IN CHILDREN AND THEIR CLINICAL SIGNIFICANCE IN SEPSIS

Abstract. Temporary immunodeficiency is often associated with various pathological conditions, such as myocardial infarction, severe trauma, or major surgery. However, there are no clinical criterions indicative for presence or absence of such immune deficiency. Meanwhile, clinical signs of infectio...

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Autores principales:	A. V. Zurochka, A. N. Kotlyarov, M. V. Kuvaytsev, S. V. Kvyatkovskaya, V. A. Zurochka, L. V. Ryabova, S. V. Khaidukov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	flow cytometry hla-dr antigens multiparametric analysis sepsis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/9b1c1a7d9de5480aab5f5e55db863fa3
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spelling	oai:doaj.org-article:9b1c1a7d9de5480aab5f5e55db863fa32021-11-18T08:03:39ZCHANGES OF HLA-DR ANTIGEN EXPRESSION ON MONOCYTES IN CHILDREN AND THEIR CLINICAL SIGNIFICANCE IN SEPSIS1563-06252313-741X10.15789/1563-0625-2008-4-5-379-388https://doaj.org/article/9b1c1a7d9de5480aab5f5e55db863fa32014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/195https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Temporary immunodeficiency is often associated with various pathological conditions, such as myocardial infarction, severe trauma, or major surgery. However, there are no clinical criterions indicative for presence or absence of such immune deficiency. Meanwhile, clinical signs of infectious complications may be absent because of deficient immune response.A technique for monitoring septic conditions in the patients with open traumas and during postsurgical period has been proposed, employing a flow-cytometric approach. The evaluation principle for septic conditions consists of measuring expression of HLA-DR antigens at the surface of peripheral blood monocytes.As a criterion of patient evaluation in septic state, a relative amount of monocytes expressing HLA-DR may be applied, and the disease prognosis is considered as favorable, if the amounts of positive cells exceed 40% by day 5 after the patient was admitted to the hospital, and an adequate treatment was carried out. This technique may find wide application for estimation and monitoring of septic conditions in the patients. (Med. Immunol., vol. 10, N 4-5, pp 379-388).A. V. ZurochkaA. N. KotlyarovM. V. KuvaytsevS. V. KvyatkovskayaV. A. ZurochkaL. V. RyabovaS. V. KhaidukovSPb RAACIarticleflow cytometryhla-dr antigensmultiparametric analysissepsisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 4-5, Pp 379-388 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	flow cytometry hla-dr antigens multiparametric analysis sepsis Immunologic diseases. Allergy RC581-607
spellingShingle	flow cytometry hla-dr antigens multiparametric analysis sepsis Immunologic diseases. Allergy RC581-607 A. V. Zurochka A. N. Kotlyarov M. V. Kuvaytsev S. V. Kvyatkovskaya V. A. Zurochka L. V. Ryabova S. V. Khaidukov CHANGES OF HLA-DR ANTIGEN EXPRESSION ON MONOCYTES IN CHILDREN AND THEIR CLINICAL SIGNIFICANCE IN SEPSIS
description	Abstract. Temporary immunodeficiency is often associated with various pathological conditions, such as myocardial infarction, severe trauma, or major surgery. However, there are no clinical criterions indicative for presence or absence of such immune deficiency. Meanwhile, clinical signs of infectious complications may be absent because of deficient immune response.A technique for monitoring septic conditions in the patients with open traumas and during postsurgical period has been proposed, employing a flow-cytometric approach. The evaluation principle for septic conditions consists of measuring expression of HLA-DR antigens at the surface of peripheral blood monocytes.As a criterion of patient evaluation in septic state, a relative amount of monocytes expressing HLA-DR may be applied, and the disease prognosis is considered as favorable, if the amounts of positive cells exceed 40% by day 5 after the patient was admitted to the hospital, and an adequate treatment was carried out. This technique may find wide application for estimation and monitoring of septic conditions in the patients. (Med. Immunol., vol. 10, N 4-5, pp 379-388).
format	article
author	A. V. Zurochka A. N. Kotlyarov M. V. Kuvaytsev S. V. Kvyatkovskaya V. A. Zurochka L. V. Ryabova S. V. Khaidukov
author_facet	A. V. Zurochka A. N. Kotlyarov M. V. Kuvaytsev S. V. Kvyatkovskaya V. A. Zurochka L. V. Ryabova S. V. Khaidukov
author_sort	A. V. Zurochka
title	CHANGES OF HLA-DR ANTIGEN EXPRESSION ON MONOCYTES IN CHILDREN AND THEIR CLINICAL SIGNIFICANCE IN SEPSIS
title_short	CHANGES OF HLA-DR ANTIGEN EXPRESSION ON MONOCYTES IN CHILDREN AND THEIR CLINICAL SIGNIFICANCE IN SEPSIS
title_full	CHANGES OF HLA-DR ANTIGEN EXPRESSION ON MONOCYTES IN CHILDREN AND THEIR CLINICAL SIGNIFICANCE IN SEPSIS
title_fullStr	CHANGES OF HLA-DR ANTIGEN EXPRESSION ON MONOCYTES IN CHILDREN AND THEIR CLINICAL SIGNIFICANCE IN SEPSIS
title_full_unstemmed	CHANGES OF HLA-DR ANTIGEN EXPRESSION ON MONOCYTES IN CHILDREN AND THEIR CLINICAL SIGNIFICANCE IN SEPSIS
title_sort	changes of hla-dr antigen expression on monocytes in children and their clinical significance in sepsis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/9b1c1a7d9de5480aab5f5e55db863fa3
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CHANGES OF HLA-DR ANTIGEN EXPRESSION ON MONOCYTES IN CHILDREN AND THEIR CLINICAL SIGNIFICANCE IN SEPSIS

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