Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs

Tumor associated macrophages (TAMs) promote cancer progression. Here, the author show that caspase-1 promotes TAMs differentiation by attenuating medium-chain acyl-CoA dehydrogenase activity and that inhibition of this axis results in suppression of tumour growth in a transgenic mouse model of breas...

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Autores principales:	Zhiyuan Niu, Qian Shi, Wenlong Zhang, Yuxin Shu, Nanfei Yang, Bing Chen, Qingsong Wang, Xuyang Zhao, Jiajia Chen, Nan Cheng, Xiujing Feng, Zichun Hua, Jianguo Ji, Pingping Shen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9b1dfe9c6f8041e2a2d8b1d09e428ffc
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spelling	oai:doaj.org-article:9b1dfe9c6f8041e2a2d8b1d09e428ffc2021-12-02T15:38:33ZCaspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs10.1038/s41467-017-00523-62041-1723https://doaj.org/article/9b1dfe9c6f8041e2a2d8b1d09e428ffc2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00523-6https://doaj.org/toc/2041-1723Tumor associated macrophages (TAMs) promote cancer progression. Here, the author show that caspase-1 promotes TAMs differentiation by attenuating medium-chain acyl-CoA dehydrogenase activity and that inhibition of this axis results in suppression of tumour growth in a transgenic mouse model of breast cancer.Zhiyuan NiuQian ShiWenlong ZhangYuxin ShuNanfei YangBing ChenQingsong WangXuyang ZhaoJiajia ChenNan ChengXiujing FengZichun HuaJianguo JiPingping ShenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhiyuan Niu Qian Shi Wenlong Zhang Yuxin Shu Nanfei Yang Bing Chen Qingsong Wang Xuyang Zhao Jiajia Chen Nan Cheng Xiujing Feng Zichun Hua Jianguo Ji Pingping Shen Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs
description	Tumor associated macrophages (TAMs) promote cancer progression. Here, the author show that caspase-1 promotes TAMs differentiation by attenuating medium-chain acyl-CoA dehydrogenase activity and that inhibition of this axis results in suppression of tumour growth in a transgenic mouse model of breast cancer.
format	article
author	Zhiyuan Niu Qian Shi Wenlong Zhang Yuxin Shu Nanfei Yang Bing Chen Qingsong Wang Xuyang Zhao Jiajia Chen Nan Cheng Xiujing Feng Zichun Hua Jianguo Ji Pingping Shen
author_facet	Zhiyuan Niu Qian Shi Wenlong Zhang Yuxin Shu Nanfei Yang Bing Chen Qingsong Wang Xuyang Zhao Jiajia Chen Nan Cheng Xiujing Feng Zichun Hua Jianguo Ji Pingping Shen
author_sort	Zhiyuan Niu
title	Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs
title_short	Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs
title_full	Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs
title_fullStr	Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs
title_full_unstemmed	Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs
title_sort	caspase-1 cleaves pparγ for potentiating the pro-tumor action of tams
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9b1dfe9c6f8041e2a2d8b1d09e428ffc
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Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs

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