Thyroid Disfunction in Critically Ill COVID-19 Patients. Relationship with In-Hospital Mortality

The incidence of thyroid disfunction has not been analyzed in critically ill COVID-19 patients. Our objective was to analyze the relationship of the thyroid profile and in-hospital mortality in critically ill COVID-19 patients. This was a prospective single-center study involving critically ill COVI...

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Autores principales:	María Antonieta Ballesteros Vizoso, Albert Figueras Castilla, Antonia Barceló, Joan Maria Raurich, Paula Argente del Castillo, Daniel Morell-García, Julio Velasco, Jon Pérez-Bárcena, Juan Antonio Llompart-Pou
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	COVID-19 critically ill patients thyroid hormones intensive care unit mortality Medicine R
Acceso en línea:	https://doaj.org/article/9b25b54292984cb29fc4529caf07604c
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spelling	oai:doaj.org-article:9b25b54292984cb29fc4529caf07604c2021-11-11T17:41:07ZThyroid Disfunction in Critically Ill COVID-19 Patients. Relationship with In-Hospital Mortality10.3390/jcm102150572077-0383https://doaj.org/article/9b25b54292984cb29fc4529caf07604c2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5057https://doaj.org/toc/2077-0383The incidence of thyroid disfunction has not been analyzed in critically ill COVID-19 patients. Our objective was to analyze the relationship of the thyroid profile and in-hospital mortality in critically ill COVID-19 patients. This was a prospective single-center study involving critically ill COVID-19 patients admitted to the ICU of a tertiary University Hospital. Thyroid hormones were measured through drawing blood samples from a central venous catheter at ICU admission and on the fifth day. A multiple logistic regression analysis was performed to analyze the variables associated with mortality. The ability of the different thyroid hormones to predict in-hospital mortality was evaluated by calculating the receiver operating characteristics (ROCs) and the area under the curve (AUC). A total of 78 patients were included in the study at ICU admission; 72 had their thyroid profile measured at day 5. In-hospital mortality reached 29.5%. Multiple logistic regression analysis showed that variables associated with mortality were age and prior beta-blocker therapy at ICU admission and age fT4 at day 5. The AUC for in-hospital mortality predictions of fT4 at day 5 was 0.69. Thyroid responses are commonly observed in critically ill COVID-19 patients. fT4 at day 5 after ICU admission was associated with mortality.María Antonieta Ballesteros VizosoAlbert Figueras CastillaAntonia BarcelóJoan Maria RaurichPaula Argente del CastilloDaniel Morell-GarcíaJulio VelascoJon Pérez-BárcenaJuan Antonio Llompart-PouMDPI AGarticleCOVID-19critically ill patientsthyroid hormonesintensive care unitmortalityMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5057, p 5057 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 critically ill patients thyroid hormones intensive care unit mortality Medicine R
spellingShingle	COVID-19 critically ill patients thyroid hormones intensive care unit mortality Medicine R María Antonieta Ballesteros Vizoso Albert Figueras Castilla Antonia Barceló Joan Maria Raurich Paula Argente del Castillo Daniel Morell-García Julio Velasco Jon Pérez-Bárcena Juan Antonio Llompart-Pou Thyroid Disfunction in Critically Ill COVID-19 Patients. Relationship with In-Hospital Mortality
description	The incidence of thyroid disfunction has not been analyzed in critically ill COVID-19 patients. Our objective was to analyze the relationship of the thyroid profile and in-hospital mortality in critically ill COVID-19 patients. This was a prospective single-center study involving critically ill COVID-19 patients admitted to the ICU of a tertiary University Hospital. Thyroid hormones were measured through drawing blood samples from a central venous catheter at ICU admission and on the fifth day. A multiple logistic regression analysis was performed to analyze the variables associated with mortality. The ability of the different thyroid hormones to predict in-hospital mortality was evaluated by calculating the receiver operating characteristics (ROCs) and the area under the curve (AUC). A total of 78 patients were included in the study at ICU admission; 72 had their thyroid profile measured at day 5. In-hospital mortality reached 29.5%. Multiple logistic regression analysis showed that variables associated with mortality were age and prior beta-blocker therapy at ICU admission and age fT4 at day 5. The AUC for in-hospital mortality predictions of fT4 at day 5 was 0.69. Thyroid responses are commonly observed in critically ill COVID-19 patients. fT4 at day 5 after ICU admission was associated with mortality.
format	article
author	María Antonieta Ballesteros Vizoso Albert Figueras Castilla Antonia Barceló Joan Maria Raurich Paula Argente del Castillo Daniel Morell-García Julio Velasco Jon Pérez-Bárcena Juan Antonio Llompart-Pou
author_facet	María Antonieta Ballesteros Vizoso Albert Figueras Castilla Antonia Barceló Joan Maria Raurich Paula Argente del Castillo Daniel Morell-García Julio Velasco Jon Pérez-Bárcena Juan Antonio Llompart-Pou
author_sort	María Antonieta Ballesteros Vizoso
title	Thyroid Disfunction in Critically Ill COVID-19 Patients. Relationship with In-Hospital Mortality
title_short	Thyroid Disfunction in Critically Ill COVID-19 Patients. Relationship with In-Hospital Mortality
title_full	Thyroid Disfunction in Critically Ill COVID-19 Patients. Relationship with In-Hospital Mortality
title_fullStr	Thyroid Disfunction in Critically Ill COVID-19 Patients. Relationship with In-Hospital Mortality
title_full_unstemmed	Thyroid Disfunction in Critically Ill COVID-19 Patients. Relationship with In-Hospital Mortality
title_sort	thyroid disfunction in critically ill covid-19 patients. relationship with in-hospital mortality
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9b25b54292984cb29fc4529caf07604c
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Thyroid Disfunction in Critically Ill COVID-19 Patients. Relationship with In-Hospital Mortality

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